Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes
Item Type: | Article |
---|
Title: | Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes |
---|
Creators Name: | Jäger, S. and Wahl, S. and Kröger, J. and Sharma, S. and Hoffmann, P. and Floegel, A. and Pischon, T. and Prehn, C. and Adamski, J. and Müller-Nurasyid, M. and Waldenberger, M. and Strauch, K. and Peters, A. and Gieger, C. and Suhre, K. and Grallert, H. and Boeing, H. and Schulze, M.B. and Meidtner, K. |
---|
Abstract: | Diabetes-associated metabolites may aid the identification of new risk variants for type 2 diabetes. Using targeted metabolomics within a subsample of the German EPIC-Potsdam study (n = 2500), we tested previously published SNPs for their association with diabetes-associated metabolites and conducted an additional exploratory analysis using data from the exome chip including replication within 2,692 individuals from the German KORA F4 study. We identified a total of 16 loci associated with diabetes-related metabolite traits, including one novel association between rs499974 (MOGAT2) and a diacyl-phosphatidylcholine ratio (PC aa C40:5/PC aa C38:5). Gene-based tests on all exome chip variants revealed associations between GFRAL and PC aa C42:1/PC aa C42:0, BIN1 and SM (OH) C22:2/SM C18:0 and TFRC and SM (OH) C22:2/SM C16:1). Selecting variants for gene-based tests based on functional annotation identified one additional association between OR51Q1 and hexoses. Among single genetic variants consistently associated with diabetes-related metabolites, two (rs174550 (FADS1), rs3204953 (REV3L)) were significantly associated with type 2 diabetes in large-scale meta-analysis for type 2 diabetes. In conclusion, we identified a novel metabolite locus in single variant analyses and four genes within gene-based tests and confirmed two previously known mGWAS loci which might be relevant for the risk of type 2 diabetes. |
---|
Keywords: | Alleles, Biomarkers, Exome, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Heritable, Quantitative Trait, Metabolome, Metabolomics, Oligonucleotide Array Sequence Analysis, Quantitative Trait Loci, Single Nucleotide, Polymorphism, Type 2,Diabetes Mellitus |
---|
Source: | Scientific Reports |
---|
ISSN: | 2045-2322 |
---|
Publisher: | Nature Publishing Group |
---|
Volume: | 7 |
---|
Number: | 1 |
---|
Page Range: | 6037 |
---|
Date: | 20 July 2017 |
---|
Official Publication: | https://doi.org/10.1038/s41598-017-06158-3 |
---|
PubMed: | View item in PubMed |
---|
Repository Staff Only: item control page
Downloads per month over past year
|