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| Item Type: | Article |
|---|---|
| Title: | CoNIC Challenge: Pushing the frontiers of nuclear detection, segmentation, classification and counting |
| Creators Name: | Graham, S. and Vu, Q.D. and Jahanifar, M. and Weigert, M. and Schmidt, U. and Zhang, W. and Zhang, J. and Yang, S. and Xiang, J. and Wang, X. and Rumberger, J.L. and Baumann, E. and Hirsch, P. and Liu, L. and Hong, C. and Aviles-Rivero, A.I. and Jain, A. and Ahn, H. and Hong, Y. and Azzuni, H. and Xu, M. and Yaqub, M. and Blache, M.C. and Piégu, B. and Vernay, B. and Scherr, T. and Böhland, M. and Löffler, K. and Li, J. and Ying, W. and Wang, C. and Snead, D. and Raza, S.E.A. and Minhas, F. and Rajpoot, N.M. |
| Abstract: | Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a community-wide challenge using the largest available dataset of its kind to assess nuclear segmentation and cellular composition. Our challenge, named CoNIC, stimulated the development of reproducible algorithms for cellular recognition with real-time result inspection on public leaderboards. We conducted an extensive post-challenge analysis based on the top-performing models using 1,658 whole-slide images of colon tissue. With around 700 million detected nuclei per model, associated features were used for dysplasia grading and survival analysis, where we demonstrated that the challenge’s improvement over the previous state-of-the-art led to significant boosts in downstream performance. Our findings also suggest that eosinophils and neutrophils play an important role in the tumour microevironment. We release challenge models and WSI-level results to foster the development of further methods for biomarker discovery. |
| Keywords: | Computational Pathology, Nuclear Recognition, Deep Learning |
| Source: | Medical Image Analysis |
| ISSN: | 1361-8415 |
| Publisher: | Elsevier |
| Volume: | 92 |
| Page Range: | 103047 |
| Date: | February 2024 |
| Additional Information: | Dagmar Kainmüller is a member of the CoNIC Challenge Consortium. |
| Official Publication: | https://doi.org/10.1016/j.media.2023.103047 |
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