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| Item Type: | Article |
|---|---|
| Title: | Maternal-derived galectin 1 shapes the placenta niche through Sda terminal glycosylation: Implication for preeclampsia |
| Creators Name: | Xie, Y. and Zhao, F. and Freitag, N. and Borowski, S. and Wang, Y. and Harms, C. and Pang, P.C. and Desforges, J. and Wen, T. and Schwedhelm, E. and Singh, M. and Dechend, R. and Dell, A. and Haslam, S.M. and Dveksler, G. and Garcia, M.G. and Blois, S.M. |
| Abstract: | Placental abnormalities cause impaired fetal growth and poor pregnancy outcome (e.g. Preeclampsia) with long lasting consequences for the mother and offspring. The molecular dialogue between the maternal niche and the developing placenta is critical for the function of this organ. Galectin-1 (gal-1), a highly expressed glycan-binding protein at the maternal-fetal interface, orchestrates the maternal adaptation to pregnancy and placenta development. Downregulation or deficiency of gal-1 during pregnancy is associated with the development of PE, however, the maternal- and placental- derived gal-1 contributions to the disease onset are largely unknown. We demonstrate that lack of gal-1 imposes a risk for PE development in a niche-specific manner and this is accompanied by a placental dysfunction highly influenced by the absence of maternal- derived gal-1. Notably, differential placental glycosylation through the Sda-capped N-glycans dominates the invasive trophoblast capacity triggered by maternal- derived gal-1. Our findings show that gal-1 derived from the maternal niche is essential for healthy placenta development and indicate that impairment of the gal-1 signaling pathway within the maternal niche could be a molecular cause for maternal cardiovascular maladaptation during pregnancy. |
| Keywords: | galectin-1, Maternal Niche, Preeclampsia, Sda Antigen, Animals, Mice |
| Source: | PNAS Nexus |
| ISSN: | 2752-6542 |
| Publisher: | Oxford University Press |
| Volume: | 2 |
| Number: | 8 |
| Page Range: | pgad247 |
| Date: | August 2023 |
| Official Publication: | https://doi.org/10.1093/pnasnexus/pgad247 |
| PubMed: | View item in PubMed |
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