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| Item Type: | Preprint |
|---|---|
| Title: | RIF1 acts as a gatekeeper of B cell identity during late differentiation |
| Creators Name: | Rahjouei, A. and Kabrani, E. and Berruezo-Llacuna, M. and Altwasser, R. and Delgado-Benito, V. and Pavri, R. and Di Virgilio, M. |
| Abstract: | RIF1 is a multifunctional protein that promotes immunoglobulin (Ig) isotype diversification. Whether RIF1 plays additional roles in adaptive immunity is unknown. In this study, we showed that Rif1 expression is upregulated following mature B cell activation, while its deficiency skewed the transcriptional profile of activated B cells towards plasmablasts (PBs) and plasma cells (PCs). Additionally, RIF1 ablation resulted in increased PB formation ex vivo and enhanced terminal differentiation into PCs upon immunization. Therefore, RIF1 serves as a cell identity gatekeeper during late B cell differentiation, providing an additional layer of control in the establishment of humoral immunity. |
| Keywords: | Mature B Cells, Differentiation, Plasma Cells, RIF1, Transcription, BLIMP1, Animals, Mice |
| Source: | bioRxiv |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Article Number: | 2023.07.18.549543v2 |
| Date: | 20 July 2023 |
| Official Publication: | https://doi.org/10.1101/2023.07.18.549543 |
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