Helmholtz Gemeinschaft


Gut microbiome and atrial fibrillation - results from a large population-based study

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
[img] Other (Supplementary Data)

Item Type:Article
Title:Gut microbiome and atrial fibrillation - results from a large population-based study
Creators Name:Palmu, J. and Börschel, C.S. and Ortega-Alonso, A. and Markó, L. and Inouye, M. and Jousilahti, P. and Salido, R.A. and Sanders, K. and Brennan, C. and Humphrey, G.C. and Sanders, J.G. and Gutmann, F. and Linz, D. and Salomaa, V. and Havulinna, A.S. and Forslund, S.K. and Knight, R. and Lahti, L. and Niiranen, T. and Schnabel, R.B.
Abstract:BACKGROUND: Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown. METHODS: We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case-control cohort of 138 individuals in Hamburg, Germany. FINDINGS: Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 539) over a median follow-up of 15 years was associated with eight microbial genera with false discovery rate (FDR)-corrected P < 0.05. Both prevalent and incident AF were associated with the genera Enorma and Bifidobacterium (FDR-corrected P < 0.001). AF was not significantly associated with bacterial diversity measures. Seventy-five percent of top genera (Enorma, Paraprevotella, Odoribacter, Collinsella, Barnesiella, Alistipes) in Cox regression analyses showed a consistent direction of shifted abundance in an independent AF case-control cohort that was used for replication. INTERPRETATION: Our findings establish the basis for the use of microbiome profiles in AF risk prediction. However, extensive research is still warranted before microbiome sequencing can be used for prevention and targeted treatment of AF.
Keywords:Atrial Fibrillation, Gut Microbiome, Metagenomics, Epidemiology
Page Range:104583
Date:May 2023
Official Publication:https://doi.org/10.1016/j.ebiom.2023.104583
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library