![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
|
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB | |
![[img]](http://edoc.mdc-berlin.de/style/images/fileicons/application_msword.png) |
MS Word (Supplementary Material)
79kB |
| Item Type: | Article |
|---|---|
| Title: | Cognition in patients with neuromyelitis optica spectrum disorders: a prospective multicentre study of 217 patients (CogniNMO-Study) |
| Creators Name: | Hümmert, M.W. and Stern, C. and Paul, F. and Duchow, A. and Bellmann-Strobl, J. and Ayzenberg, I. and Schwake, C. and Kleiter, I. and Hellwig, K. and Jarius, S. and Wildemann, B. and Senel, M. and Berthele, A. and Giglhuber, K. and Luessi, F. and Grothe, M. and Klotz, L. and Schülke, R. and Gingele, S. and Faiss, J.H. and Walter, A. and Warnke, C. and Then Bergh, F. and Aktas, O. and Ringelstein, M. and Stellmann, J.P. and Häußler, V. and Havla, J. and Pellkofer, H. and Kümpfel, T. and Kopp, B. and Trebst, C. |
| Abstract: | BACKGROUND: There is limited and inconsistent information on the prevalence of cognitive impairment in neuromyelitis optica spectrum disorders (NMOSD). OBJECTIVE: To assess cognitive performance and changes over time in NMOSD. METHODS: This study included data from 217 aquaporin-4-IgG-seropositive (80%) and double-seronegative NMOSD patients. Cognitive functions measured by Symbol Digit Modalities Test (SDMT), Paced Auditory Serial-Addition Task (PASAT), and/or Multiple Sclerosis Inventory Cognition (MuSIC) were standardized against normative data (N = 157). Intraindividual cognitive performance at 1- and 2-year follow-up was analyzed. Cognitive test scores were correlated with demographic and clinical variables and assessed with a multiple linear regression model. RESULTS: NMOSD patients were impaired in SDMT (p = 0.007), MuSIC semantic fluency (p < 0.001), and MuSIC congruent speed (p < 0.001). No significant cognitive deterioration was found at follow-up. SDMT scores were related to motor and visual disability (p(Bon) < 0.05). No differences were found between aquaporin-4-IgG-seropositive and double-seronegative NMOSD. CONCLUSIONS: A subset of NMOSD patients shows impairment in visual processing speed and in semantic fluency regardless of serostatus, without noticeable changes during a 2-year observation period. Neuropsychological measurements should be adapted to physical and visual disabilities. |
| Keywords: | Neuromyelitis Optica Spectrum Disorders, Neuroimmunology, Cognition, Cognitive Neuropsychology |
| Source: | Multiple Sclerosis Journal |
| ISSN: | 1352-4585 |
| Publisher: | Sage Publications |
| Volume: | 29 |
| Number: | 7 |
| Page Range: | 819-831 |
| Date: | June 2023 |
| Official Publication: | https://doi.org/10.1177/13524585231151212 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
Download Statistics
Download Statistics
