Synapsin autoantibodies during pregnancy are associated with fetal abnormalities
| Item Type: | Preprint |
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| Title: | Synapsin autoantibodies during pregnancy are associated with fetal abnormalities |
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| Creators Name: | Bünger, I. and Kreye, J. and Makridis, K. and Höltje, M. and Rasmussen, H.F. and Van Hoof, S. and Ullrich, T. and Sedlin, E. and Hoffmann, C. and Milovanovic, D. and Paul, F. and Meckies, J. and Verlohren, S. and Henrich, W. and Chaoui, R. and Kaindl, A. and Prüss, H. |
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| Abstract: | Anti-neuronal autoantibodies can be transplacentally transferred during pregnancy and may cause detrimental effects on fetal development. It is unclear whether autoantibodies against synapsin-I, one of the most abundant synaptic proteins, are associated with developmental abnormalities in humans. We prospectively recruited a cohort of 263 pregnant women and detected serum synapsin-I IgG autoantibodies in 13.3%. Seropositivity was strongly associated with abnormalities of fetal development including intrauterine growth retardation. This finding indicates that these autoantibodies may be clinically useful developmental biomarkers and/or even directly participate in the disease process, thus being amenable to antibody-targeting interventional strategies in the future. |
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| Keywords: | Synapsin-I, Antineuronal Autoantibodies, Transplacental Transfer, Maternofetal Autoimmunity, Growth Retardation |
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| Source: | medRxiv |
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| Publisher: | Cold Spring Harbor Laboratory Press |
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| Article Number: | 2022.09.23.22280284 |
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| Date: | 25 September 2022 |
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| Official Publication: | https://doi.org/10.1101/2022.09.23.22280284 |
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| Related to: | |
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