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Impaired motion perception is associated with functional and structural visual pathway damage in multiple sclerosis and neuromyelitis optica spectrum disorders

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Item Type:Article
Title:Impaired motion perception is associated with functional and structural visual pathway damage in multiple sclerosis and neuromyelitis optica spectrum disorders
Creators Name:Ayadi, N. and Oertel, F.C. and Asseyer, S. and Rust, R. and Duchow, A. and Kuchling, J. and Bellmann-Strobl, J. and Ruprecht, K. and Klistorner, A. and Brandt, A.U. and Paul, F. and Zimmermann, H.G.
Abstract:BACKGROUND: Decreased motion perception has been suggested as a marker for visual pathway demyelination in optic neuritis (ON) and/or multiple sclerosis (MS). OBJECTIVES: To examine the influence of neuro-axonal damage on motion perception in MS and neuromyelitis optica spectrum disorders (NMOSD). METHODS: We analysed motion perception with numbers-from-motion (NFM), visual acuity, (multifocal (mf)) VEP, optical coherence tomography in patients with MS (n = 38, confirmatory cohort n = 43), NMOSD (n = 13) and healthy controls (n = 33). RESULTS: NFM was lower compared with controls in MS (B = −12.37, p < 0.001) and NMOSD (B = −34.5, p < 0.001). NFM was lower in ON than in non-ON eyes (B = −30.95, p = 0.041) in NMOSD, but not MS. In MS and NMOSD, lower NFM was associated with worse visual acuity (B = −139.4, p < 0.001/B = −77.2, p < 0.001) and low contrast letter acuity (B = 0.99, p = 0.002/B = 1.6, p < 0.001), thinner peripapillary retinal nerve fibre layer (B = 1.0, p < 0.001/ B = 0.92, p = 0.016) and ganglion cell/inner plexiform layer (B = 64.8, p < 0.001/B = 79.5, p = 0.006), but not with VEP P100 latencies. In the confirmatory MS cohort, lower NFM was associated with thinner retinal nerve fibre layer (B = 1.351, p < 0.001) and increased mfVEP P100 latencies (B = −1.159, p < 0.001). CONCLUSIONS: Structural neuro-axonal visual pathway damage is an important driver of motion perception impairment in MS and NMOSD.
Keywords:Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Motion Perception, Retina, Vision Disorders, Optical Coherence Tomography, Visual Evoked Potentials
Source:Multiple Sclerosis Journal
ISSN:1352-4585
Publisher:Sage Publications
Volume:28
Number:5
Page Range:757-767
Date:April 2022
Official Publication:https://doi.org/10.1177/13524585211032801
PubMed:View item in PubMed

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