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Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)

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Item Type:Review
Title:Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
Creators Name:Blois, S.M. and Verlohren, S. and Wu, G. and Clark, G. and Dell, A. and Haslam, S.M. and Barrientos, G.
Abstract:Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.
Keywords:Galectins, Preterm Birth, Microbial Infections, Glycans
Source:Seminars in Immunopathology
Page Range:469-486
Date:August 2020
Official Publication:https://doi.org/10.1007/s00281-020-00801-4
PubMed:View item in PubMed

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