Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
Item Type: | Review |
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Title: | Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB) |
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Creators Name: | Blois, S.M. and Verlohren, S. and Wu, G. and Clark, G. and Dell, A. and Haslam, S.M. and Barrientos, G. |
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Abstract: | Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome. |
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Keywords: | Galectins, Preterm Birth, Microbial Infections, Glycans |
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Source: | Seminars in Immunopathology |
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ISSN: | 1863-2297 |
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Publisher: | Springer |
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Volume: | 42 |
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Number: | 4 |
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Page Range: | 469-486 |
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Date: | August 2020 |
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Official Publication: | https://doi.org/10.1007/s00281-020-00801-4 |
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PubMed: | View item in PubMed |
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