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Involvement of mossy cells in sharp wave-ripple activity in vitro

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Item Type:Article
Title:Involvement of mossy cells in sharp wave-ripple activity in vitro
Creators Name:Swaminathan, A. and Wichert, I. and Schmitz, D. and Maier, N.
Abstract:The role of mossy cells (MCs) of the hippocampal dentate area has long remained mysterious. Recent research has begun to unveil their significance in spatial computation of the hippocampus. Here, we used an in vitro model of sharp wave-ripple complexes (SWRs), which contribute to hippocampal memory formation, to investigate MC involvement in this fundamental population activity. We find that a significant fraction of MCs (~47%) is recruited into the active neuronal network during SWRs in the CA3 area. Moreover, MCs receive pronounced, ripple-coherent, excitatory and inhibitory synaptic input. Finally, we find evidence for SWR-related synaptic activity in granule cells that is mediated by MCs. Given the widespread connectivity of MCs within and between hippocampi, our data suggest a role for MCs as a hub functionally coupling the CA3 and the DG during ripple-associated computations.
Keywords:Animals, Mice
Source:Cell Reports
ISSN:2211-1247
Publisher:Cell Press / Elsevier (U.S.A.)
Volume:23
Number:9
Page Range:2541-2549
Date:29 May 2018
Official Publication:https://doi.org/10.1016/j.celrep.2018.04.095
PubMed:View item in PubMed

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