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| Item Type: | Article |
|---|---|
| Title: | Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit |
| Creators Name: | Edemann-Callesen, H., Habelt, B., Wieske, F., Jackson, M., Khadka, N., Mattei, D., Bernhardt, N., Heinz, A., Liebetanz, D., Bikson, M., Padberg, F., Hadar, R., Nitsche, N. and Winter, C. |
| Abstract: | Involuntary movements as seen in repetitive disorders such as Tourette Syndrome (TS) results from cortical hyperexcitability that arise due to striato-thalamo-cortical circuit (STC) imbalance. Transcranial direct current stimulation (tDCS) is a stimulation procedure that changes cortical excitability, yet its relevance in repetitive disorders such as TS remains largely unexplored. Here, we employed the dopamine transporter-overexpressing (DAT-tg) rat model to investigate behavioral and neurobiological effects of frontal tDCS. The outcome of tDCS was pathology dependent, as anodal tDCS decreased repetitive behavior in the DAT-tg rats yet increased it in wild-type (wt) rats. Extensive deep brain stimulation (DBS) application and computational modeling assigned the response in DAT-tg rats to the sensorimotor pathway. Neurobiological assessment revealed cortical activity changes and increase in striatal inhibitory properties in the DAT-tg rats. Our findings show that tDCS reduces repetitive behavior in the DAT-tg rat through modulation of the sensorimotor STC circuit. This sets the stage for further investigating the usage of tDCS in repetitive disorders such as TS. |
| Keywords: | Cerebral Cortex, Corpus Striatum, Animal, Disease Models, Dopamine Plasma Membrane Transport Proteins, Electroencephalography, Magnetic Resonance Imaging, Tourette Syndrome, Transcranial Direct Current Stimulation, Animals, Rats |
| Source: | Translational Psychiatry |
| ISSN: | 2158-3188 |
| Publisher: | Nature Publishing Group |
| Volume: | 8 |
| Number: | 1 |
| Page Range: | 11 |
| Date: | 10 January 2018 |
| Official Publication: | https://doi.org/10.1038/s41398-017-0059-5 |
| PubMed: | View item in PubMed |
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