Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit

Edemann-Callesen, H.; Habelt, B.; Wieske, F.; Jackson, M.; Khadka, N.; Mattei, D.; Bernhardt, N.; Heinz, A.; Liebetanz, D.; Bikson, M.; Padberg, F.; Hadar, R.; Nitsche, N.; Winter, C.

Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit

Tools

Preview	PDF (Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 1MB
	MS Word (Supplementary Information) 486kB

Item Type:	Article
Title:	Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
Creators Name:	Edemann-Callesen, H., Habelt, B., Wieske, F., Jackson, M., Khadka, N., Mattei, D., Bernhardt, N., Heinz, A., Liebetanz, D., Bikson, M., Padberg, F., Hadar, R., Nitsche, N. and Winter, C.
Abstract:	Involuntary movements as seen in repetitive disorders such as Tourette Syndrome (TS) results from cortical hyperexcitability that arise due to striato-thalamo-cortical circuit (STC) imbalance. Transcranial direct current stimulation (tDCS) is a stimulation procedure that changes cortical excitability, yet its relevance in repetitive disorders such as TS remains largely unexplored. Here, we employed the dopamine transporter-overexpressing (DAT-tg) rat model to investigate behavioral and neurobiological effects of frontal tDCS. The outcome of tDCS was pathology dependent, as anodal tDCS decreased repetitive behavior in the DAT-tg rats yet increased it in wild-type (wt) rats. Extensive deep brain stimulation (DBS) application and computational modeling assigned the response in DAT-tg rats to the sensorimotor pathway. Neurobiological assessment revealed cortical activity changes and increase in striatal inhibitory properties in the DAT-tg rats. Our findings show that tDCS reduces repetitive behavior in the DAT-tg rat through modulation of the sensorimotor STC circuit. This sets the stage for further investigating the usage of tDCS in repetitive disorders such as TS.
Keywords:	Cerebral Cortex, Corpus Striatum, Animal, Disease Models, Dopamine Plasma Membrane Transport Proteins, Electroencephalography, Magnetic Resonance Imaging, Tourette Syndrome, Transcranial Direct Current Stimulation, Animals, Rats
Source:	Translational Psychiatry
ISSN:	2158-3188
Publisher:	Nature Publishing Group
Volume:	8
Number:	1
Page Range:	11
Date:	10 January 2018
Official Publication:	https://doi.org/10.1038/s41398-017-0059-5
PubMed:	View item in PubMed

Repository Staff Only: item control page

Download Statistics

Downloads

Downloads per month over past year