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Article

Activation of gp130 signaling in T cells drives T(H)17-mediated multi-organ autoimmunity.
Baumgartner, F., Bamopoulos, S.A., Faletti, L., Hsiao, H.J., Holz, M., Gonzalez-Menendez, I., Solé-Boldo, L., Horne, A., Gosavi, S., Özerdem, C., Singh, N., Liebig, S., Ramamoorthy, S., Lehmann, M., Demel, U., Kühl, A.A., Wartewig, T., Ruland, J., Wunderlich, F.T., Schick, M., Walther, W., Rose-John, S., Haas, S., Quintanilla-Martinez, L., Feske, S., Ehl, S., Glauben, R. and Keller, U.
Science Signaling 17 (824): eadc9662. 20 February 2024

PI3K-C2β limits mTORC1 signaling and angiogenic growth.
Kobialka, P., Llena, J., Deleyto-Seldas, N., Munar-Gelabert, M., Dengra, J.A., Villacampa, P., Albinyà-Pedrós, A., Muixi, L., Andrade, J., van Splunder, H., Angulo-Urarte, A., Potente, M., Grego-Bessa, J., Castillo, S.D., Vanhaesebroeck, B., Efeyan, A. and Graupera, M.
Science Signaling 16 (813): eadg1913. November 2023

Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1.
Lo, A., Holmes, K., Kamlapurkar, S., Mundt, F., Moorthi, S., Fung, I., Fereshetian, S., Watson, J., Carr, S.A., Mertins, P. and Berger, A.H.
Science Signaling 14 (711): eabc4520. 30 November 2021

Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells.
Fischer, C., Metsger, M., Bauch, S., Vidal, R., Böttcher, M., Grote, P., Kliem, M. and Sauer, S.
Science Signaling 12 (581): eaao5820. 14 May 2019

G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.
Pusapati, G.V., Kong, J.H., Patel, B.B., Gouti, M., Sagner, A., Sircar, R., Luchetti, G., Ingham, P.W., Briscoe, J. and Rohatgi, R.
Science Signaling 11 (516): eaao5749. 6 February 2018

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.
Frischauf, I., Litviňuková, M., Schober, R., Zayats, V., Svobodova, B., Bonhenry, D., Lunz, V., Cappello, S., Tociu, L., Reha, D., Stallinger, A., Hochreiter, A., Pammer, T., Butorac, C., Muik, M., Groschner, K., Bogeski, I., Ettrich, R.H., Romanin, C. and Schindl, R.
Science Signaling 10 (507): eaao0358. 28 November 2017

Rapid multiplex analysis of lipid raft components with single-cell resolution.
Schatzlmaier, P., Supper, V., Göschl, L., Zwirzitz, A., Eckerstorfer, P., Ellmeier, W., Huppa, J.B. and Stockinger, H.
Science Signaling 8 (395): rs11. September 2015

ALK pERKs up MYCN in neuroblastoma.
Lindner, S., Henssen, A., Astrahantseff, K. and Schulte, J.H.
Science Signaling 7 (349): pe27. 28 October 2014

Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes.
Thurley, K., Tovey, S.C., Moenke, G., Prince, V.L., Meena, A., Thomas, A.P., Skupin, A., Taylor, C.W. and Falcke, M.
Science Signaling 7 (331): ra59. 24 June 2014

KCNQ1, KCNE2, and Na(+)-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.
Abbott, G.W, Tai, K.K., Neverisky, D.L., Hansler, A., Hu, Z., Roepke, T.K., Lerner, D.J., Chen, Q., Liu, L., Zupan, B., Toth, M., Haynes, R., Huang, X., Demirbas, D., Buccafusca, R., Gross, S.S., Kanda, V.A. and Berry, G.T.
Science Signaling 7 (315): ra22. 4 March 2014

ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.
Norton, M., Ng, A.C., Baird, S., Dumoulin, A., Shutt, T., Mah, N., Andrade-Navarro, M.A., McBride, H.M. and Screaton, R.A.
Science Signaling 7 (310): ra10. 28 January 2014

Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Willoughby, D., Everett, K.L., Halls, M.L., Pacheco, J., Skroblin, P., Vaca, L., Klussmann, E. and Cooper, D.M.
Science Signaling 5 (219): ra29. 10 April 2012

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam, A., Stelzl, U., Foulle, R., Plassmann, S., Zenkner, M., Timm, J., Assmus, H.E., Andrade-Navarro, M.A. and Wanker, E.E.
Science Signaling 4 (189): rs8. 6 September 2011

Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.
Lorentzen, A., Kinkhabwala, A., Rocks, O., Vartak, N. and Bastiaens, P.I.
Science Signaling 3 (140): ra68. 21 September 2010

Linear motif atlas for phosphorylation-dependent signaling.
Miller, M.L., Jensen, L.J., Diella, F., Jorgensen, C., Tinti, M., Li, L., Hsiung, M., Parker, S.A., Bordeaux, J., Sicheritz-Ponten, T., Olhovsky, M., Pasculescu, A., Alexander, J., Knapp, S., Blom, N., Bork, P., Li, S., Cesareni, G., Pawson, T., Turk, B.E., Yaffe, M.B., Brunak, S. and Linding, R.
Science Signaling 1 (35): ra2. 2 September 2008

Geranylgeranylation but not GTP-loading of Rho GTPases determines T cell function.
Waiczies, S., Bendix, I. and Zipp, F.
Science Signaling 1 (12): pt3. 25 March 2008

Review

Degrons in cancer.
Meszaros, B., Kumar, M., Gibson, T.J., Uyar, B. and Dosztanyi, Z.
Science Signaling 10 (470): eaak9982. 14 March 2017