Article

Glutamatergic argonaute2 promotes the formation of the neurovascular unit in mice.
Sona, C. ORCID: https://orcid.org/0000-0003-3107-016X, Yeh, Y.T. ORCID: https://orcid.org/0000-0001-7968-6081, Li, Y. ORCID: https://orcid.org/0009-0006-6992-9098, Liu, X., Ghosh, A. ORCID: https://orcid.org/0000-0002-5160-4571, Hinte, L.C. ORCID: https://orcid.org/0000-0002-4226-0009, Ku, M.C. ORCID: https://orcid.org/0000-0003-0963-2461, Rathjen, T., Niendorf, T. ORCID: https://orcid.org/0000-0001-7584-6527, Yu, G. ORCID: https://orcid.org/0000-0002-5194-8614, Jia, S. ORCID: https://orcid.org/0000-0001-8595-9314, Kononenko, N.L., Hermann, A. ORCID: https://orcid.org/0000-0002-7364-7791, Luo, J. ORCID: https://orcid.org/0000-0001-5169-3095, Lin, J. ORCID: https://orcid.org/0000-0001-9300-1771, von Meyenn, F. ORCID: https://orcid.org/0000-0001-9920-3075, Yan, X. ORCID: https://orcid.org/0000-0002-9135-7915 and Poy, M.N. ORCID: https://orcid.org/0000-0002-4904-2426
Science Signaling 18 (875): eadl6745. 25 February 2025

Activation of gp130 signaling in T cells drives T(H)17-mediated multi-organ autoimmunity.
Baumgartner, F. ORCID: https://orcid.org/0000-0003-0768-1956, Bamopoulos, S.A. ORCID: https://orcid.org/0000-0002-5997-7735, Faletti, L. ORCID: https://orcid.org/0000-0002-9213-2478, Hsiao, H.J., Holz, M. ORCID: https://orcid.org/0009-0002-1294-8205, Gonzalez-Menendez, I., Solé-Boldo, L. ORCID: https://orcid.org/0000-0002-6974-9066, Horne, A. ORCID: https://orcid.org/0000-0002-4209-4573, Gosavi, S., Özerdem, C. ORCID: https://orcid.org/0000-0001-6772-0422, Singh, N., Liebig, S. ORCID: https://orcid.org/0000-0002-5494-8476, Ramamoorthy, S. ORCID: https://orcid.org/0000-0003-3468-4247, Lehmann, M. ORCID: https://orcid.org/0000-0002-3786-7375, Demel, U. ORCID: https://orcid.org/0000-0002-6480-4185, Kühl, A.A. ORCID: https://orcid.org/0000-0003-2293-5387, Wartewig, T. ORCID: https://orcid.org/0000-0001-8699-1690, Ruland, J. ORCID: https://orcid.org/0000-0002-8381-3597, Wunderlich, F.T. ORCID: https://orcid.org/0000-0002-9209-3501, Schick, M. ORCID: https://orcid.org/0009-0003-8626-0611, Walther, W. ORCID: https://orcid.org/0000-0003-2884-0231, Rose-John, S. ORCID: https://orcid.org/0000-0002-7519-3279, Haas, S. ORCID: https://orcid.org/0000-0001-9227-2051, Quintanilla-Martinez, L., Feske, S., Ehl, S. ORCID: https://orcid.org/0000-0002-9265-2721, Glauben, R. ORCID: https://orcid.org/0000-0003-2889-2525 and Keller, U. ORCID: https://orcid.org/0000-0002-8485-1958
Science Signaling 17 (824): eadc9662. 20 February 2024

PI3K-C2β limits mTORC1 signaling and angiogenic growth.
Kobialka, P. ORCID: https://orcid.org/0000-0003-4765-168X, Llena, J. ORCID: https://orcid.org/0000-0002-5648-2606, Deleyto-Seldas, N. ORCID: https://orcid.org/0009-0002-0270-7336, Munar-Gelabert, M., Dengra, J.A., Villacampa, P. ORCID: https://orcid.org/0000-0002-2860-7475, Albinyà-Pedrós, A., Muixi, L. ORCID: https://orcid.org/0000-0002-9110-0474, Andrade, J. ORCID: https://orcid.org/0000-0002-4577-8620, van Splunder, H., Angulo-Urarte, A. ORCID: https://orcid.org/0000-0002-8024-814X, Potente, M. ORCID: https://orcid.org/0000-0002-5689-0036, Grego-Bessa, J. ORCID: https://orcid.org/0000-0002-0938-2346, Castillo, S.D. ORCID: https://orcid.org/0000-0002-7007-3155, Vanhaesebroeck, B. ORCID: https://orcid.org/0000-0002-7074-3673, Efeyan, A. ORCID: https://orcid.org/0000-0002-3806-6799 and Graupera, M. ORCID: https://orcid.org/0000-0003-4608-4185
Science Signaling 16 (813): eadg1913. November 2023

Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1.
Lo, A. ORCID: https://orcid.org/0000-0001-6128-9846, Holmes, K. ORCID: https://orcid.org/0000-0001-9645-4709, Kamlapurkar, S., Mundt, F., Moorthi, S., Fung, I., Fereshetian, S., Watson, J. ORCID: https://orcid.org/0000-0003-2677-3696, Carr, S.A. ORCID: https://orcid.org/0000-0002-7203-4299, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X and Berger, A.H. ORCID: https://orcid.org/0000-0002-6538-2658
Science Signaling 14 (711): eabc4520. 30 November 2021

Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells.
Fischer, C. ORCID: https://orcid.org/0000-0003-0329-2435, Metsger, M. ORCID: https://orcid.org/0000-0001-9722-0533, Bauch, S., Vidal, R. ORCID: https://orcid.org/0000-0003-4217-2014, Böttcher, M., Grote, P., Kliem, M. and Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693
Science Signaling 12 (581): eaao5820. 14 May 2019

G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.
Pusapati, G.V., Kong, J.H., Patel, B.B., Gouti, M. ORCID: https://orcid.org/0000-0001-7422-1605, Sagner, A., Sircar, R., Luchetti, G., Ingham, P.W., Briscoe, J. and Rohatgi, R.
Science Signaling 11 (516): eaao5749. 6 February 2018

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.
Frischauf, I., Litviňuková, M. ORCID: https://orcid.org/0000-0002-6713-3647, Schober, R., Zayats, V., Svobodova, B., Bonhenry, D., Lunz, V., Cappello, S., Tociu, L., Reha, D., Stallinger, A., Hochreiter, A., Pammer, T., Butorac, C., Muik, M., Groschner, K., Bogeski, I., Ettrich, R.H., Romanin, C. and Schindl, R.
Science Signaling 10 (507): eaao0358. 28 November 2017

Rapid multiplex analysis of lipid raft components with single-cell resolution.
Schatzlmaier, P., Supper, V., Göschl, L., Zwirzitz, A., Eckerstorfer, P., Ellmeier, W., Huppa, J.B. ORCID: https://orcid.org/0000-0003-2634-8198 and Stockinger, H.
Science Signaling 8 (395): rs11. September 2015

ALK pERKs up MYCN in neuroblastoma.
Lindner, S., Henssen, A. ORCID: https://orcid.org/0000-0003-1534-778X, Astrahantseff, K. and Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201
Science Signaling 7 (349): pe27. 28 October 2014

Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes.
Thurley, K., Tovey, S.C., Moenke, G., Prince, V.L., Meena, A., Thomas, A.P., Skupin, A., Taylor, C.W. and Falcke, M. ORCID: https://orcid.org/0000-0001-7137-1114
Science Signaling 7 (331): ra59. 24 June 2014

KCNQ1, KCNE2, and Na(+)-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.
Abbott, G.W, Tai, K.K., Neverisky, D.L., Hansler, A., Hu, Z., Roepke, T.K., Lerner, D.J., Chen, Q., Liu, L., Zupan, B., Toth, M., Haynes, R., Huang, X., Demirbas, D., Buccafusca, R., Gross, S.S., Kanda, V.A. and Berry, G.T.
Science Signaling 7 (315): ra22. 4 March 2014

ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.
Norton, M., Ng, A.C., Baird, S., Dumoulin, A., Shutt, T., Mah, N. ORCID: https://orcid.org/0000-0002-1240-8076, Andrade-Navarro, M.A. ORCID: https://orcid.org/0000-0001-6650-1711, McBride, H.M. and Screaton, R.A.
Science Signaling 7 (310): ra10. 28 January 2014

Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Willoughby, D., Everett, K.L., Halls, M.L., Pacheco, J., Skroblin, P. ORCID: https://orcid.org/0000-0003-0321-3493, Vaca, L., Klussmann, E. ORCID: https://orcid.org/0000-0003-4004-5003 and Cooper, D.M.
Science Signaling 5 (219): ra29. 10 April 2012

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam, A., Stelzl, U. ORCID: https://orcid.org/0000-0003-2500-3585, Foulle, R., Plassmann, S., Zenkner, M., Timm, J., Assmus, H.E., Andrade-Navarro, M.A. ORCID: https://orcid.org/0000-0001-6650-1711 and Wanker, E.E. ORCID: https://orcid.org/0000-0001-8072-1630
Science Signaling 4 (189): rs8. 6 September 2011

Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.
Lorentzen, A., Kinkhabwala, A., Rocks, O. ORCID: https://orcid.org/0000-0001-6349-9193, Vartak, N. and Bastiaens, P.I.
Science Signaling 3 (140): ra68. 21 September 2010

Linear motif atlas for phosphorylation-dependent signaling.
Miller, M.L., Jensen, L.J. ORCID: https://orcid.org/0000-0001-7885-715X, Diella, F., Jorgensen, C., Tinti, M., Li, L., Hsiung, M., Parker, S.A., Bordeaux, J., Sicheritz-Ponten, T., Olhovsky, M., Pasculescu, A., Alexander, J., Knapp, S., Blom, N., Bork, P. ORCID: https://orcid.org/0000-0002-2627-833X, Li, S., Cesareni, G., Pawson, T., Turk, B.E., Yaffe, M.B., Brunak, S. and Linding, R.
Science Signaling 1 (35): ra2. 2 September 2008

Geranylgeranylation but not GTP-loading of Rho GTPases determines T cell function.
Waiczies, S. ORCID: https://orcid.org/0000-0002-9916-9572, Bendix, I. ORCID: https://orcid.org/0000-0002-9751-3640 and Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928
Science Signaling 1 (12): pt3. 25 March 2008

Review

Degrons in cancer.
Meszaros, B., Kumar, M., Gibson, T.J. ORCID: https://orcid.org/0000-0003-0657-5166, Uyar, B. ORCID: https://orcid.org/0000-0002-3170-4890 and Dosztanyi, Z. ORCID: https://orcid.org/0000-0002-3624-5937
Science Signaling 10 (470): eaak9982. 14 March 2017