Browse by Journal Title

2024

Peripheral priming induces plastic transcriptomic and proteomic responses in circulating neutrophils required for pathogen containment.
Kaiser, R. and Gold, C. and Joppich, M. and Loew, Q. and Akhalkatsi, A. and Mueller, T.T. and Offensperger, F. and Droste Zu Senden, A. and Popp, O. and di Fina, L. and Knottenberg, V. and Martinez-Navarro, A. and Eivers, L. and Anjum, A. and Escaig, R. and Bruns, N. and Briem, E. and Dewender, R. and Muraly, A. and Akgöl, S. and Ferraro, B. and Hoeflinger, J.K.L. and Polewka, V. and Khaled, N.B. and Allgeier, J. and Tiedt, S. and Dichgans, M. and Engelmann, B. and Enard, W. and Mertins, P. and Hubner, N. and Weckbach, L. and Zimmer, R. and Massberg, S. and Stark, K. and Nicolai, L. and Pekayvaz, K.
Science Advances 10 (12): eadl1710. 22 March 2024

Clonal dominance defines metastatic dissemination in pancreatic cancer.
Ho, I.L. and Li, C.Y. and Wang, F. and Zhao, L. and Liu, J. and Yen, E.Y. and Dyke, C.A. and Shah, R. and Liu, Z. and Çetin, A.O. and Chu, Y. and Citron, F. and Attanasio, S. and Corti, D. and Darbaniyan, F. and Del Poggetto, E. and Loponte, S. and Liu, J. and Soeung, M. and Chen, Z. and Jiang, S. and Jiang, H. and Inoue, A. and Gao, S. and Deem, A. and Feng, N. and Ying, H. and Kim, M. and Giuliani, V. and Genovese, G. and Zhang, J. and Futreal, A. and Maitra, A. and Heffernan, T. and Wang, L. and Do, K.A. and Gargiulo, G. and Draetta, G. and Carugo, A. and Lin, R. and Viale, A.
Science Advances 10 (11): eadd9342. 15 March 2024

Gamma oscillation plasticity is mediated via parvalbumin interneurons.
Hadler, M.D. and Tzilivaki, A. and Schmitz, D. and Alle, H. and Geiger, J.R.P.
Science Advances 10 (5): eadj7427. 2 February 2024

2023

Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts.
Ilia, K. and Shakiba, N. and Bingham, T. and Jones, R.D. and Kaminski, M.M. and Aravera, E. and Bruno, S. and Palacios, S. and Weiss, R. and Collins, J.J. and Del Vecchio, D. and Schlaeger, T.M.
Science Advances 9 (48): eadg8495. December 2023

XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.
Chatzinikolaou, G. and Stratigi, K. and Siametis, A. and Goulielmaki, E. and Akalestou-Clocher, A. and Tsamardinos, I. and Topalis, P. and Austin, C. and Bouwman, B.A.M. and Crosetto, N. and Altmüller, J. and Garinis, G.A.
Science Advances 9 (45): eadi2095. 10 November 2023

Molecular basis of ClC-6 function and its impairment in human disease.
Zhang, B. and Zhang, S. and Polovitskaya, M.M. and Yi, J. and Ye, B. and Li, R. and Huang, X. and Yin, J. and Neuens, S. and Balfroid, T. and Soblet, J. and Vens, D. and Aeby, A. and Li, X. and Cai, J. and Song, Y. and Li, Y. and Tartaglia, M. and Li, Y. and Jentsch, T.J. and Yang, M. and Liu, Z.
Science Advances 9 (41): eadg4479. 13 October 2023

Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion.
Rejeski, K. and Perez, A. and Iacoboni, G. and Blumenberg, V. and Bücklein, V.L. and Völkl, S. and Penack, O. and Albanyan, O. and Stock, S. and Müller, F. and Karschnia, P. and Petrera, A. and Reid, K. and Faramand, R. and Davila, M.L. and Modi, K. and Dean, E.A. and Bachmeier, C. and von Bergwelt-Baildon, M. and Locke, F.L. and Bethge, W. and Bullinger, L. and Mackensen, A. and Barba, P. and Jain, M.D. and Subklewe, M.
Science Advances 9 (38): eadg3919. 22 September 2023

Pharmacological modulators of epithelial immunity uncovered by synthetic genetic tracing of SARS-CoV-2 infection responses.
Jiang, B. and Schmitt, M.J. and Rand, U. and Company, C. and Dramaretska, Y. and Grossmann, M. and Serresi, M. and Cicin-Sain, L. and Gargiulo, G.
Science Advances 9 (25): eadf4975. 23 June 2023

Analysis of volume and topography of adipose tissue in the trunk: Results of MRI of 11,141 participants in the German National Cohort.
Haueise, T. and Schick, F. and Stefan, N. and Schlett, C.L. and Weiss, J.B. and Nattenmüller, J. and Göbel-Guéniot, K. and Norajitra, T. and Nonnenmacher, T. and Kauczor, H.U. and Maier-Hein, K.H. and Niendorf, T. and Pischon, T. and Jöckel, K.H. and Umutlu, L. and Peters, A. and Rospleszcz, S. and Kröncke, T. and Hosten, N. and Völzke, H. and Krist, L. and Willich, S.N. and Bamberg, F. and Machann, J.
Science Advances 9 (19): eadd0433. 12 May 2023

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance.
Danielli, S.G. and Porpiglia, E. and De Micheli, A.J. and Navarro, N. and Zellinger, M.J. and Bechtold, I. and Kisele, S. and Volken, L. and Marques, J.G. and Kasper, S. and Bode, P.K. and Henssen, A.G. and Gürgen, D. and Delattre, O. and Surdez, D. and Roma, J. and Bühlmann, P. and Blau, H.M. and Wachtel, M. and Schäfer, B.W.
Science Advances 9 (6): eade9238. 10 February 2023

2022

Robust induction of primordial germ cells of white rhinoceros on the brink of extinction.
Hayashi, M. and Zywitza, V. and Naitou, Y. and Hamazaki, N. and Goeritz, F. and Hermes, R. and Holtze, S. and Lazzari, G. and Galli, C. and Stejskal, J. and Diecke, S. and Hildebrandt, T.B. and Hayashi, K.
Science Advances 8 (49): eabp9683. 9 December 2022

MicroRNAs are deeply linked to the emergence of the complex octopus brain.
Zolotarov, G. and Fromm, B. and Legnini, I. and Ayoub, S. and Polese, G. and Maselli, V. and Chabot, P.J. and Vinther, J. and Styfhals, R. and Seuntjens, E. and Di Cosmo, A. and Peterson, K.J. and Rajewsky, N.
Science Advances 8 (47): eadd9938. 25 November 2022

Structural insights into crista junction formation by the Mic60-Mic19 complex.
Bock-Bierbaum, T. and Funck, K. and Wollweber, F. and Lisicki, E. and von der Malsburg, K. and von der Malsburg, A. and Laborenz, J. and Noel, J.K. and Hessenberger, M. and Jungbluth, S. and Bernert, C. and Kunz, S. and Riedel, D. and Lilie, H. and Jakobs, S. and van der Laan, M. and Daumke, O.
Science Advances 8 (35): eabo4946. 2 September 2022

A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.
Jäger, K. and Mensch, J. and Grimmig, M.E. and Neuner, B. and Gorzelniak, K. and Türkmen, S. and Demuth, I. and Hartmann, A. and Hartmann, C. and Wittig, F. and Sporbert, A. and Hermann, A. and Fuellen, G. and Möller, S. and Walter, M.
Science Advances 8 (33): eabk2814. August 2022

IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
Garnier, L. and Pick, R. and Montorfani, J. and Sun, M. and Brighouse, D. and Liaudet, N. and Kammertoens, T. and Blankenstein, T. and Page, N. and Bernier-Latamani, J. and Tran, N.L. and Petrova, T.V. and Merkler, D. and Scheiermann, C. and Hugues, S.
Science Advances 8 (23): eabl5162. 8 June 2022

Precise CRISPR/Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells.
Tran, N.T. and Danner, E. and Li, X. and Graf, R. and Lebedin, M. and de la Rosa, K. and Kühn, R. and Rajewsky, K. and Chu, V.T.
Science Advances 8 (22): eabm9106. 3 June 2022

Selective endocytosis of Ca(2+)-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.
Azarnia Tehran, D. and Kochlamazashvili, G. and Pampaloni, N. P. and Sposini, S. and Shergill, J.K. and Lehmann, M. and Pashkova, N. and Schmidt, C. and Löwe, D. and Napieczynska, H. and Heuser, A. and Plested, A.J.R. and Perrais, D. and Piper, R.C. and Haucke, V. and Maritzen, T.
Science Advances 8 (21): eabl5032. 27 May 2022

Adolescence is a sensitive period for prefrontal microglia to act on cognitive development.
Schalbetter, S.M. and von Arx, A.S. and Cruz-Ochoa, N. and Dawson, K. and Ivanov, A. and Mueller, F.S. and Lin, H.Y. and Amport, R. and Mildenberger, W. and Mattei, D. and Beule, D. and Földy, C. and Greter, M. and Notter, T. and Meyer, U.
Science Advances 8 (9): eabi6672. 4 March 2022

Gating choreography and mechanism of the human proton-activated chloride channel ASOR.
Wang, C. and Polovitskaya, M.M. and Delgado, B.D. and Jentsch, T.J. and Long, S.B.
Science Advances 8 (5): eabm3942. 2 February 2022

An uncertainty-aware, shareable, and transparent neural network architecture for brain-age modeling.
Hahn, T. and Ernsting, J. and Winter, N.R. and Holstein, V. and Leenings, R. and Beisemann, M. and Fisch, L. and Sarink, K. and Emden, D. and Opel, N. and Redlich, R. and Repple, J. and Grotegerd, D. and Meinert, S. and Hirsch, J.G. and Niendorf, T. and Endemann, B. and Bamberg, F. and Kröncke, T. and Bülow, R. and Völzke, H. and von Stackelberg, O. and Sowade, R.F. and Umutlu, L. and Schmidt, B. and Caspers, S. and Kugel, H. and Kircher, T. and Risse, B. and Gaser, C. and Cole, J.H. and Dannlowski, U. and Berger, K.
Science Advances 8 (1): eabg9471. 7 January 2022

2021

R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage.
Chatzidoukaki, O. and Stratigi, K. and Goulielmaki, E. and Niotis, G. and Akalestou-Clocher, A. and Gkirtzimanaki, K. and Zafeiropoulos, A. and Altmüller, J. and Topalis, P. and Garinis, G.A.
Science Advances 7 (47): eabj5769. 19 November 2021

RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.
Zhang, S. and Übelmesser, N. and Josipovic, N. and Forte, G. and Slotman, J.A. and Chiang, M. and Gothe, H.J. and Gusmao, E.G. and Becker, C. and Altmüller, J. and Houtsmuller, A.B. and Roukos, V. and Wendt, K.S. and Marenduzzo, D. and Papantonis, A.
Science Advances 7 (43): eabg8205. 22 October 2021

Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques.
Bewley, K.R. and Gooch, K. and Thomas, K.M. and Longet, S. and Wiblin, N. and Hunter, L. and Chan, K. and Brown, P. and Russell, R. A. and Ho, C. and Slack, G. and Humphries, H.E. and Alden, L. and Allen, L. and Aram, M. and Baker, N. and Brunt, E. and Cobb, R. and Fotheringham, S. and Harris, D. and Kennard, C. and Leung, S. and Ryan, K. and Tolley, H. and Wand, N. and White, A. and Sibley, L. and Sarfas, C. and Pearson, G. and Rayner, E. and Xue, X. and Lambe, T. and Charlton, S. and Gilbert, S. and Sattentau, Q.J. and Gleeson, F. and Hall, Y. and Funnell, S. and Sharpe, S. and Salguero, F.J. and Gorringe, A. and Carroll, M.
Science Advances 7 (37): eabg7996. 10 September 2021

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization.
Turner, H.L. and Andrabi, R. and Cottrell, C.A. and Richey, S.T. and Song, G. and Callaghan, S. and Anzanello, F. and Moyer, T.J. and Abraham, W. and Melo, M. and Silva, M. and Scaringi, N. and Rakasz, E.G. and Sattentau, Q.J. and Irvine, D.J. and Burton, D.R. and Ward, A.B.
Science Advances 7 (31): eabh2791. July 2021

Structure of the merozoite surface protein 1 from Plasmodium falciparum.
Dijkman, P.M. and Marzluf, T. and Zhang, Y. and Chang, S.Y.S. and Helm, D. and Lanzer, M. and Bujard, H. and Kudryashev, M.
Science Advances 7 (23): eabg0465. June 2021

Functional antagonism of chromatin modulators regulates epithelial-mesenchymal transition.
Serresi, M. and Kertalli, S. and Li, L. and Schmitt, M.J. and Dramaretska, Y. and Wierikx, J. and Hulsman, D. and Gargiulo, G.
Science Advances 7 (9): eabd7974. 24 February 2021

2020

Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer.
Le Poul, Y. and Xin, Y. and Ling, L. and Mühling, B. and Jaenichen, R. and Hörl, D. and Bunk, D. and Harz, H. and Leonhardt, H. and Wang, Y. and Osipova, E. and Museridze, M. and Dharmadhikari, D. and Murphy, E. and Rohs, R. and Preibisch, S. and Prud'homme, B. and Gompel, N.
Science Advances 6 (49): eabe2955. 2 December 2020

Microscopy with undetected photons in the mid-infrared.
Kviatkovsky, I. and Chrzanowski, H.M. and Avery, E.G. and Bartolomaeus, H. and Ramelow, S.
Science Advances 6 (42): eabd0264. 14 October 2020

Viral cGAMP nuclease reveals the essential role of DNA sensing in protection against acute lethal virus infection.
Hernáez, B. and Alonso, G. and Georgana, I. and El-Jesr, M. and Martín, R. and Shair, K.H.Y. and Fischer, C. and Sauer, S. and Maluquer de Motes, C. and Alcamí, A.
Science Advances 6 (38): eabb4565. 18 September 2020

The NEMP family supports metazoan fertility and nuclear envelope stiffness.
Tsatskis, Y. and Rosenfeld, R. and Pearson, J.D. and Boswell, C. and Qu, Y. and Kim, K. and Fabian, L. and Mohammad, A. and Wang, X. and Robson, M.I. and Krchma, K. and Wu, J. and Gonçalves, J. and Hodzic, D. and Wu, S. and Potter, D. and Pelletier, L. and Dunham, W.H. and Gingras, A.C. and Sun, Y. and Meng, J. and Godt, D. and Schedl, T. and Ciruna, B. and Choi, K. and Perry, J.R.B. and Bremner, R. and Schirmer, E.C. and Brill, J.A. and Jurisicova, A. and McNeill, H.
Science Advances 6 (35): eabb4591. 28 August 2020

2019

In vivo-mimicking microfluidic perfusion culture of pancreatic islet spheroids.
Jun, Y. and Lee, J.S. and Choi, S. and Yang, J.H. and Sander, M. and Chung, S. and Lee, S.H.
Science Advances 5 (11): eaax4520. 1 November 2019

Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML.
Jakobsen, J.S. and Laursen, L.G. and Schuster, M.B. and Pundhir, S. and Schoof, E. and Ge, Y. and d'Altri, T. and Vitting-Seerup, K. and Rapin, N. and Gentil, C. and Jendholm, J. and Theilgaard-Mönch, K. and Reckzeh, K. and Bullinger, L. and Döhner, K. and Hokland, P. and Fitzgibbon, J. and Porse, B.T.
Science Advances 5 (7): eaaw4304. July 2019

2016

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
Andlauer, T.F.M. and Buck, D. and Antony, G. and Bayas, A. and Bechmann, L. and Berthele, A. and Chan, A. and Gasperi, C. and Gold, R. and Graetz, C. and Haas, J. and Hecker, M. and Infante-Duarte, C. and Knop, M. and Kümpfel, T. and Limmroth, V. and Linker, R.A. and Loleit, V. and Luessi, F. and Meuth, S.G. and Muehlau, M. and Nischwitz, S. and Paul, F. and Pütz, M. and Ruck, T. and Salmen, A. and Stangel, M. and Stellmann, J.P. and Stuerner, K.H. and Tackenberg, B. and Then Bergh, F. and Tumani, H. and Warnke, C. and Weber, F. and Wiendl, H. and Wildemann, B. and Zettl, U.K. and Ziemann, U. and Zipp, F. and Arloth, J. and Weber, P. and Radivojkov-Blagojevic, M. and Scheinhardt, M.O. and Dankowski, T. and Bettecken, T. and Lichtner, P. and Czamara, D. and Carrillo-Roa, T. and Binder, E.B. and Berger, K. and Bertram, L. and Franke, A. and Gieger, C. and Herms, S. and Homuth, G. and Ising, M. and Jöckel, K.H. and Kacprowski, T. and Kloiber, S. and Laudes, M. and Lieb, W. and Lill, C.M. and Lucae, S. and Meitinger, T. and Moebus, S. and Mueller-Nurasyid, M. and Nöthen, M.M. and Petersmann, A. and Rawal, R. and Schminke, U. and Strauch, K. and Völzke, H. and Waldenberger, M. and Wellmann, J. and Porcu, E. and Mulas, A. and Pitzalis, M. and Sidore, C. and Zara, I. and Cucca, F. and Zoledziewska, M. and Ziegler, A. and Hemmer, B. and Müller-Myhsok, B.
Science Advances 2 (6): e1501678. 17 June 2016

Bacterial antisense RNAs are mainly the product of transcriptional noise.
Llorens-Rico, V. and Cano, J. and Kamminga, T. and Gil, R. and Latorre, A. and Chen, W.H. and Bork, P. and Glass, J.I. and Serrano, L. and Lluch-Senar, M.
Science Advances 2 (3): e1501363. 4 March 2016