Preprint

Modulating psoriasis microbiome: a clinical trial on mare's milk impact.
Colino, Silvia González ORCID: https://orcid.org/0009-0007-8959-9636, Löber, Ulrike ORCID: https://orcid.org/0000-0001-7468-9531, Forslund, Sofia ORCID: https://orcid.org/0000-0003-4285-6993, Yermekbayeva, Bakytgul, Kozhakhmetov, Samat, Algazina, Togzhan, Touir, Gulnaz, Batpenova, Gulnar and Kushugulova, Almagul
Research Square : rs.3.rs-9814787/v1. 8 June 2026

Meal-induced changes in cardiometabolic peptides in the context of acute cardiovascular diseases and glucose metabolism.
Lishkova, Gergana, Schweizerhof, Oliver, Großmann, Julia, von Rohr, Katharina, Landmesser, Ulf, Edelmann, Frank, Eckardt, Kai-Uwe, Endres, Matthias, Weber, Joachim, Pischon, Tobias ORCID: https://orcid.org/0000-0003-1568-767X, Schulz-Menger, Jeanette ORCID: https://orcid.org/0000-0003-3100-1092, Mueller, Dominik ORCID: https://orcid.org/0000-0003-3650-5644, Spranger, Joachim ORCID: https://orcid.org/0000-0002-8900-4467, Li, Linna and Mai, Knut
Research Square : rs-9456874/v1. 8 May 2026

Plant-forward diets lower circulating TMAO in adults: a systematic review and meta-analysis.
Zupo, Roberta, Castellana, Fabio, Catino, Feliciana, Lampignano, Luisa, Zheng, Yalin, Lip, Gregory, Mastrangelo, Annalaura, Ikram, Mohammad Arfan, Rodriguez-Mateos, Ana, Menni, Cristina, Cuthbertson, D.J., Pischon, Tobias ORCID: https://orcid.org/0000-0003-1568-767X, Nimptsch, Katharina ORCID: https://orcid.org/0000-0001-7877-205X, Raymond, Frederic, Muhamadali, Howbeer, Petukhov, Ivan Andrushevich, Isanejad, Masoud and Sardone, Rodolfo
Research Square : rs.3.rs-9382739/v1. 14 April 2026

Host and lifestyle factors associated with the anterior nares’ microbiome diversity and composition: a cross-sectional analysis based on the German National Cohort (NAKO).
Bardenhorst, Sven Kleine, Baurecht, Hansjörg, Becher, Heiko, Berger, Klaus, Brenner, Hermann, Günther, Kathrin, Harth, Volker, Holleczek, Bernd, Kaaks, Rudolf, Karch, André, Keil, Thomas, Kemmling, Yvonne, Khattak, Muhammad N.K., Klee, Bianca, Klett-Tammen, Carolina, Krist, Lilian, Lange, Berit, Leitzmann, Michael, Lieb, Wolfgang, Michels, Karin B., Mikolajczyk, Rafael, Nauck, Matthias, Nimptsch, Katharina ORCID: https://orcid.org/0000-0001-7877-205X, Obi, Nadia, Peters, Annette, Pischon, Tobias ORCID: https://orcid.org/0000-0003-1568-767X, Schikowski, Tamara, Schmidt, Börge, Schulze, Matthias B., Six-Merker, Julia, Wirkner, Kerstin, Wolters, Maike, Woltemate, Sabrina, Vital, Marius and Rübsamen, Nicole
Research Square : rs.3.rs-9116334/v1. 1 April 2026

Combinatorial tumor suppressor gene targeting immortalizes primary pancreatic ductal cells, resulting in temporal, deterministic structural patterns across the genome.
Felsenstein, Matthäus, Hu, Mengwen, Ma, Dou, Tamboli, Jenny, Jin, Cao Zhong Jing, Wang, Ruonan, Hui, Luan Xiao, Dubois, Frank ORCID: https://orcid.org/0000-0002-7654-6208, Neumann, Christopher, Dolnik, Anna, Hillebrandt, Karl Herbert, Haderer, Luna, Giurgiu, Madalina ORCID: https://orcid.org/0000-0001-5007-7442, Henssen, Anton ORCID: https://orcid.org/0000-0003-1534-778X, Kübler, Kirsten, Pratschke, Johann, Malinka, Thomas, Sauer, Igor, Wood, Laura ORCID: https://orcid.org/0000-0003-3096-652X and Roberts, Nicholas ORCID: https://orcid.org/0000-0002-8709-0664
Research Square : rs-9124723/v1. 27 March 2026

Patient-specific B-cell lymphoma modeling identifies cooperating genetic alterations and the critical influence of patient context.
Konrath, Fabian ORCID: https://orcid.org/0000-0002-6843-6252, Denker, Sophy ORCID: https://orcid.org/0000-0002-0736-6019, Schmitt, Clemens ORCID: https://orcid.org/0000-0002-4731-2226, Chapuy, Björn ORCID: https://orcid.org/0000-0002-6485-8773 and Wolf, Jana ORCID: https://orcid.org/0000-0003-3254-5868
Research Square : rs.3.rs-9022766/v1. 12 March 2026

Morphogenetic ovarian modules for oocyte production from germline stem cells.
Hart, Neta, Kroll, Johanna B. ORCID: https://orcid.org/0000-0003-4652-3598, Kumar, Vineet, Czukiewska, Sylwia M. ORCID: https://orcid.org/0000-0001-9151-9008, Bogoch, Yoel, Guler, Noga ORCID: https://orcid.org/0009-0004-8560-1995, Levy, Karine ORCID: https://orcid.org/0000-0003-0290-062X, Chuva de Sousa Lopes, Susana M., Junker, Jan Philipp ORCID: https://orcid.org/0000-0002-2826-8290 and Elkouby, Yaniv M. ORCID: https://orcid.org/0000-0002-9043-4106
Research Square : rs-7325126/v1. 28 October 2025

Functional microbiome reprogramming links dietary interventions to neuroin ammatory outcomes in multiple sclerosis.
Gutmann, Friederike ORCID: https://orcid.org/0000-0001-6763-2270, Bahr, Lina Samira ORCID: https://orcid.org/0000-0001-7932-8639, Brüning, Ulrike ORCID: https://orcid.org/0000-0003-0112-4032, Jarquín-Díaz, Víctor Hugo ORCID: https://orcid.org/0000-0003-3758-1091, Markó, Lajos ORCID: https://orcid.org/0000-0003-1888-5575, Weygandt, Martin ORCID: https://orcid.org/0000-0001-9962-4582, Rust, Rebekka ORCID: https://orcid.org/0000-0002-9075-103X, Bellmann-Strobl, Judith ORCID: https://orcid.org/0000-0003-2615-1643, Paul, Friedemann ORCID: https://orcid.org/0000-0002-6378-0070, Forslund-Startceva, Sofia K. ORCID: https://orcid.org/0000-0003-4285-6993 and Kirwan, Jennifer A. ORCID: https://orcid.org/0000-0002-5423-1651
Research Square : rs.3.rs-7434844. 12 September 2025

Structural basis for membrane targeting and secretion of legionella SidE ubiquitin ligases.
Misra, Mohit ORCID: https://orcid.org/0000-0001-6309-8066, Mukherjee, Rukmini, Bhattacharya, Anshu, Weng, Tsai-Hsuan ORCID: https://orcid.org/0000-0002-3708-6384, Li, Chuang, Chen, Wenbo, van Ek, Larissa ORCID: https://orcid.org/0000-0002-8047-1560, Mohammed, Ahmed, Cristiani, Alberto, Liu, Yaobin, Pomirska, Julia, Vidov, Adela, Grewe, Diana, van der Heden van Noort, Gerbrand ORCID: https://orcid.org/0000-0001-5955-6431, Hummer, Gerhard ORCID: https://orcid.org/0000-0001-7768-746X, Gavin, Anne-Claude ORCID: https://orcid.org/0000-0003-4917-2340, Safarian, Schara, Luo, Zhao-Qing ORCID: https://orcid.org/0000-0001-8890-6621, Bhaskara, Ramachandra ORCID: https://orcid.org/0000-0002-7742-0391, Svergun, Dmitri, Kudryashev, Misha ORCID: https://orcid.org/0000-0003-3550-6274 and Dikic, Ivan ORCID: https://orcid.org/0000-0001-8156-9511
Research Square : rs.3.rs-6524297/v1. 12 May 2025

Spermidine mitigates immune cell senescence, enhances autophagy, and boosts vaccine responses in healthy older adults.
Alsaleh, Ghada ORCID: https://orcid.org/0000-0002-4211-3420, Ali, Mohammad, Kayvanjoo, Amir ORCID: https://orcid.org/0000-0003-1315-8336, Liu, Feng, Bibi, Sagida, Luo, Lin ORCID: https://orcid.org/0000-0003-2300-5448, Govender, Melissa, Carroll, Miles, Hofer, Sebastian ORCID: https://orcid.org/0000-0002-0756-0014, Eisenberg, Tobias ORCID: https://orcid.org/0000-0003-3559-1130, Magnes, Christoph, Kell, Loren ORCID: https://orcid.org/0000-0003-1322-2027, Chung, Christopher, Deng, Yu, Bhandari, Aneesha, Chen, Liye, Kronsteiner-Dobramysl, Barbara, Dunachie, Susie, Spiller, Owen, Lambe, Teresa, Klenerman, Paul, Jones, Lucy and Simon, Anna Katharina ORCID: https://orcid.org/0000-0002-4077-7995
Research Square : rs.3.rs-5686388. 2 April 2025

Cerebral small vessel disease may not critically influence familial Parkinson’s disease.
Marhat, B., Bimala, M., Foddis, M., Holtgrewe, M. ORCID: https://orcid.org/0000-0002-3051-1763, Beule, D. ORCID: https://orcid.org/0000-0002-3284-0632, Bras, J., Guerreiro, R., Kola, V., Schmitt, H.M., Endres, M. and Sassi, C.
Research Square : rs.3.rs-4518069. 26 June 2024

Delphi hackathon – a new approach to develop Core Outcome Sets for blood cancers.
Lang, K.M. ORCID: https://orcid.org/0000-0001-8855-884X, de Waal, E., Bereczky, T., Dawoud, D., Geissler, J., Bolanos, N., Sanz, G., Guillevic, Y., Rivas, J.M.H., van den Berg, L., Barbus, M., Schulze-Rath, R. and Bullinger, L. ORCID: https://orcid.org/0000-0002-5890-5510
Research Square : rs-3961968/v1. 30 April 2024

Establishment of kidney cancer organoid cultures.
Bauer, D. ORCID: https://orcid.org/0000-0002-2933-4333, Birchmeier, W. ORCID: https://orcid.org/0000-0003-1173-0829 and Fendler, A. ORCID: https://orcid.org/0000-0002-7267-0981
Research Square : rs.3.pex-911. 12 May 2020