Preprint

Host and lifestyle factors associated with the anterior nares’ microbiome diversity and composition: a cross-sectional analysis based on the German National Cohort (NAKO).
Bardenhorst, Sven Kleine, Baurecht, Hansjörg, Becher, Heiko, Berger, Klaus, Brenner, Hermann, Günther, Kathrin, Harth, Volker, Holleczek, Bernd, Kaaks, Rudolf, Karch, André, Keil, Thomas, Kemmling, Yvonne, Khattak, Muhammad N.K., Klee, Bianca, Klett-Tammen, Carolina, Krist, Lilian, Lange, Berit, Leitzmann, Michael, Lieb, Wolfgang, Michels, Karin B., Mikolajczyk, Rafael, Nauck, Matthias, Nimptsch, Katharina, Obi, Nadia, Peters, Annette, Pischon, Tobias, Schikowski, Tamara, Schmidt, Börge, Schulze, Matthias B., Six-Merker, Julia, Wirkner, Kerstin, Wolters, Maike, Woltemate, Sabrina, Vital, Marius and Rübsamen, Nicole
Research Square : rs.3.rs-9116334/v1. 1 April 2026

Combinatorial tumor suppressor gene targeting immortalizes primary pancreatic ductal cells, resulting in temporal, deterministic structural patterns across the genome.
Felsenstein, Matthäus, Hu, Mengwen, Ma, Dou, Tamboli, Jenny, Jin, Cao Zhong Jing, Wang, Ruonan, Hui, Luan Xiao, Dubois, Frank, Neumann, Christopher, Dolnik, Anna, Hillebrandt, Karl Herbert, Haderer, Luna, Giurgiu, Madalina, Henssen, Anton, Kübler, Kirsten, Pratschke, Johann, Malinka, Thomas, Sauer, Igor, Wood, Laura and Roberts, Nicholas
Research Square : rs-9124723/v1. 27 March 2026

Patient-specific B-cell lymphoma modeling identifies cooperating genetic alterations and the critical influence of patient context.
Konrath, Fabian, Denker, Sophy, Schmitt, Clemens, Chapuy, Björn and Wolf, Jana
Research Square : rs.3.rs-9022766/v1. 12 March 2026

Morphogenetic ovarian modules for oocyte production from germline stem cells.
Hart, Neta, Kroll, Johanna B., Kumar, Vineet, Czukiewska, Sylwia M., Bogoch, Yoel, Guler, Noga, Levy, Karine, Chuva de Sousa Lopes, Susana M., Junker, Jan Philipp and Elkouby, Yaniv M.
Research Square : rs-7325126/v1. 28 October 2025

Functional microbiome reprogramming links dietary interventions to neuroin ammatory outcomes in multiple sclerosis.
Gutmann, Friederike, Bahr, Lina Samira, Brüning, Ulrike, Jarquín-Díaz, Víctor Hugo, Markó, Lajos, Weygandt, Martin, Rust, Rebekka, Bellmann-Strobl, Judith, Paul, Friedemann, Forslund-Startceva, Sofia K. and Kirwan, Jennifer A.
Research Square : rs.3.rs-7434844. 12 September 2025

Single-cell multi-omics resolved analysis of mitochondrial genome-wide mutational burden, constraint, and mosaicism.
Hsieh, Yu-Hsin, Kautz, Pauline, Nitsch, Lena, Giguelay, Ambre M., Liebold, Janet, Zsurka, Gábor, Trombly, Genevieve, Schülke, Markus, Kunz, Wolfram S., Lareau, Caleb and Ludwig, Leif S.
Research Square : rs.3.rs-6539733/v1. 20 May 2025

Structural basis for membrane targeting and secretion of legionella SidE ubiquitin ligases.
Misra, Mohit, Mukherjee, Rukmini, Bhattacharya, Anshu, Weng, Tsai-Hsuan, Li, Chuang, Chen, Wenbo, van Ek, Larissa, Mohammed, Ahmed, Cristiani, Alberto, Liu, Yaobin, Pomirska, Julia, Vidov, Adela, Grewe, Diana, van der Heden van Noort, Gerbrand, Hummer, Gerhard, Gavin, Anne-Claude, Safarian, Schara, Luo, Zhao-Qing, Bhaskara, Ramachandra, Svergun, Dmitri, Kudryashev, Misha and Dikic, Ivan
Research Square : rs.3.rs-6524297/v1. 12 May 2025

Spermidine mitigates immune cell senescence, enhances autophagy, and boosts vaccine responses in healthy older adults.
Alsaleh, Ghada, Ali, Mohammad, Kayvanjoo, Amir, Liu, Feng, Bibi, Sagida, Luo, Lin, Govender, Melissa, Carroll, Miles, Hofer, Sebastian, Eisenberg, Tobias, Magnes, Christoph, Kell, Loren, Chung, Christopher, Deng, Yu, Bhandari, Aneesha, Chen, Liye, Kronsteiner-Dobramysl, Barbara, Dunachie, Susie, Spiller, Owen, Lambe, Teresa, Klenerman, Paul, Jones, Lucy and Simon, Anna Katharina
Research Square : rs.3.rs-5686388. 2 April 2025

Cerebral small vessel disease may not critically influence familial Parkinson’s disease.
Marhat, B., Bimala, M., Foddis, M., Holtgrewe, M., Beule, D., Bras, J., Guerreiro, R., Kola, V., Schmitt, H.M., Endres, M. and Sassi, C.
Research Square : rs.3.rs-4518069. 26 June 2024

Delphi hackathon – a new approach to develop Core Outcome Sets for blood cancers.
Lang, K.M., de Waal, E., Bereczky, T., Dawoud, D., Geissler, J., Bolanos, N., Sanz, G., Guillevic, Y., Rivas, J.M.H., van den Berg, L., Barbus, M., Schulze-Rath, R. and Bullinger, L.
Research Square : rs-3961968/v1. 30 April 2024

Establishment of kidney cancer organoid cultures.
Bauer, D., Birchmeier, W. and Fendler, A.
Research Square : rs.3.pex-911. 12 May 2020