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Article

MLL1 is required for maintenance of intestinal stem cells.
Goveas, N. and Waskow, C. and Arndt, K. and Heuberger, J. and Zhang, Q. and Alexopoulou, D. and Dahl, A. and Birchmeier, W. and Anastassiadis, K. and Stewart, A.F. and Kranz, A.
PLoS Genetics 17 (12): e1009250. 3 December 2021

Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease.
Audain, E. and Wilsdon, A. and Breckpot, J. and Izarzugaza, J.M. and Fitzgerald, T.W. and Kahlert, A.K. and Sifrim, A. and Wünnemann, F. and Perez-Riverol, Y. and Abdul-Khaliq, H. and Bak, M. and Bassett, A.S. and Benson, W.D. and Berger, F. and Daehnert, I. and Devriendt, K. and Dittrich, S. and Daubeney, P.E. and Garg, V. and Hackmann, K. and Hoff, K. and Hofmann, P. and Dombrowsky, G. and Pickardt, T. and Bauer, U. and Keavney, B.D. and Klaassen, S. and Kramer, H.H. and Marshall, C.R. and Milewicz, D.M. and Lemaire, S. and Coselli, J.S. and Mitchell, M.E. and Tomita-Mitchell, A. and Prakash, S.K. and Stamm, K. and Stewart, A.F.R. and Silversides, C.K. and Siebert, R. and Stiller, B. and Rosenfeld, J.A. and Vater, I. and Postma, A.V. and Caliebe, A. and Brook, J.D. and Andelfinger, G. and Hurles, M.E. and Thienpont, B. and Larsen, L.A. and Hitz, M.P.
PLoS Genetics 17 (7): e1009679. 29 July 2021

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
Swan, A.L. and Schütt, C. and Rozman, J. and Del Mar Muñiz Moreno, M. and Brandmaier, S. and Simon, M. and Leuchtenberger, S. and Griffiths, M. and Brommage, R. and Keskivali-Bond, P. and Grallert, H. and Werner, T. and Teperino, R. and Becker, L. and Miller, G. and Moshiri, A. and Seavitt, J.R. and Cissell, D.D. and Meehan, T.F. and Acar, E.F. and Lelliott, C.J. and Flenniken, A.M. and Champy, M.F. and Sorg, T. and Ayadi, A. and Braun, R.E. and Cater, H. and Dickinson, M.E. and Flicek, P. and Gallegos, J. and Ghirardello, E.J. and Heaney, J.D. and Jacquot, S. and Lally, C. and Logan, J.G. and Teboul, L. and Mason, J. and Spielmann, N. and McKerlie, C. and Murray, S.A. and Nutter, L.M.J. and Odfalk, K.F. and Parkinson, H. and Prochazka, J. and Reynolds, C.L. and Selloum, M. and Spoutil, F. and Svenson, K.L. and Vales, T.S. and Wells, S.E. and White, J.K. and Sedlacek, R. and Wurst, W. and Lloyd, K.K.C. and Croucher, P.I. and Fuchs, H. and Williams, G.R. and Bassett, D. and Gailus-Durner, V. and Herault, Y. and Mallon, A.M. and Brown, S.D.M. and Mayer-Kuckuk, P. and Hrabe de Angelis, M.
PLoS Genetics 16 (12): e1009190. 28 December 2020

Age-of-onset information helps identify 76 genetic variants associated with allergic disease.
Ferreira, M.A.R. and Vonk, J.M. and Baurecht, H. and Marenholz, I. and Tian, C. and Hoffman, J.D. and Helmer, Q. and Tillander, A. and Ullemar, Vi. and Lu, Y. and Grosche, S. and Rüschendorf, F. and Granell, R. and Brumpton, B.M. and Fritsche, L.G. and Bhatta, L. and Gabrielsen, M.E. and Nielsen, J.B. and Zhou, W. and Hveem, K. and Langhammer, A. and Holmen, O.L. and Løset, M. and Abecasis, G.R. and Willer, C.J. and Emami, N.C. and Cavazos, T.B. and Witte, J.S. and Szwajda, A. and Hinds, D.A. and Hübner, N. and Weidinger, S. and Magnusson, P.K. and Jorgenson, E. and Karlsson, R. and Paternoster, L. and Boomsma, D.I. and Almqvist, C. and Lee, Y.A. and Koppelman, G.H.
PLoS Genetics 16 (6): e1008725. 30 June 2020

A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing.
Chen, T. and Zhang, B. and Ziegenhals, T. and Prusty, A.B. and Fröhler, S. and Grimm, C. and Hu, Y. and Schaefke, B. and Fang, L. and Zhang, M. and Kraemer, N. and Kaindl, A.M. and Fischer, U. and Chen, W.
PLoS Genetics 15 (10): e1008460. 31 October 2019

Genomic inversions and GOLGA core duplicons underlie disease instability at the 15q25 locus.
Maggiolini, F.A.M. and Cantsilieris, S. and D'Addabbo, P. and Manganelli, M. and Coe, B.P. and Dumont, B.L. and Sanders, A.D. and Pang, A.W.C. and Vollger, M.R. and Palumbo, O. and Palumbo, P. and Accadia, M. and Carella, M. and Eichler, E.E. and Antonacci, F.
PLoS Genetics 15 (3): e1008075. 27 March 2019

The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea.
Schmidt, D. and Reuter, H. and Hüttner, K. and Ruhe, L. and Rabert, F. and Seebeck, F. and Irimia, M. and Solana, J. and Bartscherer, K.
PLoS Genetics 14 (12): e1007828. 17 December 2018

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.
Bonnin, E. and Cabochette, P. and Filosa, A. and Jühlen, R. and Komatsuzaki, S. and Hezwani, M. and Dickmanns, A. and Martinelli, V. and Vermeersch, M. and Supply, L. and Martins, N. and Pirenne, L. and Ravenscroft, G. and Lombard, M. and Port, S. and Spillner, C. and Janssens, S. and Roets, E. and Van Dorpe, J. and Lammens, M. and Kehlenbach, R.H. and Ficner, R. and Laing, N.G. and Hoffmann, K. and Vanhollebeke, B. and Fahrenkrog, B.
PLoS Genetics 14 (12): e1007845. 13 December 2018

Unraveling the transcriptional regulation of TWIST1 in limb development.
Hirsch, N. and Eshel, R. and Bar Yaacov, R. and Shahar, T. and Shmulevich, F. and Dahan, I. and Levaot, N. and Kaplan, T. and Lupiáñez, D.G. and Birnbaum, R..
PLoS Genetics 14 (10): e1007738. 29 October 2018

Evolutionary plasticity in the innate immune function of Akirin.
Polanowska, J. and Chen, J.X. and Soulé, J. and Omi, S. and Belougne, J. and Taffoni, C. and Pujol, N. and Selbach, M. and Zugasti, O. and Ewbank, J.J.
PLoS Genetics 14 (7): e1007494. 23 July 2018

Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure.
Salatzki, J. and Foryst-Ludwig, A. and Bentele, K. and Blumrich, A. and Smeir, E. and Ban, Z. and Brix, S. and Grune, J. and Beyhoff, N. and Klopfleisch, R. and Dunst, S. and Surma, M.A. and Klose, C. and Rothe, M. and Heinzel, F.R. and Krannich, A. and Kershaw, E.E. and Beule, D. and Schulze, P.C. and Marx, N. and Kintscher, U.
PLoS Genetics 14 (1): e1007171. 10 January 2018

Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.
Ravindran, E. and Hu, H. and Yuzwa, S.A. and Hernandez-Miranda, L.R. and Kraemer, N. and Ninnemann, O. and Musante, L. and Boltshauser, E. and Schindler, D. and Hübner, A. and Reinecker, H.-C. and Ropers, H.-H. and Birchmeier, C. and Miller, F.D. and Wienker, T.F. and Hübner, C. and Kaindl, A.M.
PLoS Genetics 13 (4): e1006746. 28 April 2017

Ectodysplasin/NF-κB promotes mammary cell fate via Wnt/β-catenin pathway.
Voutilainen, M. and Lindfors, P.H. and Trela, E. and Loennblad, D. and Shirokova, V. and Elo, T. and Rysti, E. and Schmidt-Ullrich, R. and Schneider, P. and Mikkola, M.L.
PLoS Genetics 11 (11): e1005676. 18 November 2015

A gene regulatory program for meiotic prophase in the fetal ovary.
Soh, Y.Q.S. and Junker, J.P. and Gill, M.E. and Mueller, J.L. and van Oudenaarden, A. and Page, D.C.
PLoS Genetics 11 (9): e1005531. 17 September 2015

In vivo evidence for lysosome depletion and impaired autophagic clearance in hereditary spastic paraplegia type SPG11.
Varga, R.E. and Khundadze, M. and Damme, M. and Nietzsche, S. and Hoffmann, B. and Stauber, T. and Koch, N. and Hennings, J.C. and Franzka, P. and Huebner, A.K. and Kessels, M.M. and Biskup, C. and Jentsch, T.J. and Qualmann, B. and Braulke, T. and Kurth, I. and Beetz, C. and Hübner, C.A.
PLoS Genetics 11 (8): e1005454. 18 August 2015

Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance.
Esparza-Gordillo, J. and Matanovic, A. and Marenholz, I. and Bauerfeind, A. and Rohde, K. and Nemat, K. and Lee-Kirsch, M.A. and Nordenskjöld, M. and Winge, M.C.G. and Keil, T. and Krüger, R. and Lau, S. and Beyer, K. and Kalb, B. and Niggemann, B. and Hübner, N. and Cordell, H.J. and Bradley, M. and Lee, Y.A.
PLoS Genetics 11 (3): e1005076. 10 March 2015

Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling.
Hu, Y.C. and Nicholls, P.K. and Soh, Y.Q.S. and Daniele, J.R. and Junker, J.P. and van Oudenaarden, A. and Page, D.C.
PLoS Genetics 11 (3): e1005019. 4 March 2015

microRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes.
Blevins, R. and Bruno, L. and Carroll, T. and Elliott, J. and Marcais, A. and Loh, C. and Hertweck, A. and Krek, A. and Rajewsky, N. and Chen, C.Z. and Fisher, A.G. and Merkenschlager, M.
PLoS Genetics 11 (2): e1005020. 25 February 2015

Suicidal autointegration of Sleeping Beauty and piggyBac transposons in eukaryotic cells.
Wang, Y. and Wang, J. and Devaraj, A. and Singh, M. and Jimenez Orgaz, A. and Chen, J.X. and Selbach, M. and Ivics, Z. and Izsvák, Z.
PLoS Genetics 10 (3): e1004103. 13 March 2014

Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.
Cevik, S. and Sanders, A.A.W.M. and Van Wijk, E. and Boldt, K. and Clarke, L. and van Reeuwijk, J. and Hori, Y. and Horn, N. and Hetterschijt, L. and Wdowicz, A. and Mullins, A. and Kida, K. and Kaplan, O.I. and van Beersum, S.E.C. and Man Wu, K. and Letteboer, S.J.F. and Mans, D.A. and Katada, T. and Kontani, K. and Ueffing, M. and Roepman, R. and Kremer, H. and Blacque, O.E.
PLoS Genetics 9 (12): e1003977. December 2013

The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation.
Solana, J. and Gamberi, C. and Mihaylova, Y. and Grosswendt, S. and Chen, C. and Lasko, P. and Rajewsky, N. and Aboobaker, A.A.
PLoS Genetics 9 (12): e1004003. December 2013

Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery.
Zhang, G. and Hoersch, S. and Amsterdam, A. and Whittaker, C.A. and Beert, E. and Catchen, J.M. and Farrington, S. and Postlethwait, J.H. and Legius, E. and Hopkins, N. and Lees, J.A.
PLoS Genetics 9 (8): e1003734. August 2013

Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of Mammalian sex determination.
Munger, S.C. and Natarajan, A. and Looger, L.L. and Ohler, U. and Capel, B.
PLoS Genetics 9 (7): e1003630. 11 July 2013

Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
Wallach, T and Schellenberg, K and Maier, B and Kalathur, R.K. and Porras, P. and Wanker, E.E. and Futschik, M.E. and Kramer, A.
PLoS Genetics 9 (3): e1003398. March 2013

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.
Schaffer, A.E. and Taylor, B.L. and Benthuysen, J.R. and Liu, J. and Thorel, F. and Yuan, W. and Jiao, Y. and Kaestner, K.H. and Herrera, P.L. and Magnuson, M.A. and May, C.L. and Sander, M.
PLoS Genetics 9 (1): e1003274. 31 January 2013

Rare copy number variants contribute to congenital left-sided heart disease.
Hitz, M.P. and Lemieux-Perreault, L.P. and Marshall, C. and Feroz-Zada, Y. and Davies, R. and Yang, S.W. and Lionel, A.C. and D'Amours, G. and Lemyre, E. and Cullum, R. and Bigras, J.L. and Thibeault, M. and Chetaille, P. and Montpetit, A. and Khairy, P. and Overduin, B. and Klaassen, S. and Hoodless, P. and Awadalla, P. and Hussin, J. and Idaghdour, Y. and Nemer, M. and Stewart, A.F. and Boerkoel, C. and Scherer, S.W. and Richter, A. and Dube, M.P. and Andelfinger, G.
PLoS Genetics 8 (9): e1002903. 6 September 2012

Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1.
Petrakis, S. and Rasko, T. and Russ, J. and Friedrich, R.P. and Stroedicke, M. and Riechers, S.P. and Muehlenberg, K. and Moeller, A. and Reinhardt, A. and Vinayagam, A. and Schaefer, M.H. and Boutros, M. and Tricoire, H. and Andrade-Navarro, M.A. and Wanker, E.E.
PLoS Genetics 8 (8): e1002897. 16 August 2012

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia.
Akalin, A. and Garrett-Bakelman, F.E. and Kormaksson, M. and Busuttil, J. and Zhang, L. and Khrebtukova, I. and Milne, T.A. and Huang, Y. and Biswas, D. and Hess, J.L. and Allis, C.D. and Roeder, R.G. and Valk, P.J.M. and Loewenberg, B. and Delwel, R. and Fernandez, H.F. and Paietta, E. and Tallman, M.S. and Schroth, G.P. and Mason, C.E. and Melnick, A. and Figueroa, M.E.
PLoS Genetics 8 (6): e1002781. 21 June 2012

An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity.
Kuehnen, P. and Mischke, M. and Wiegand, S. and Sers, C. and Horsthemke, B. and Lau, S. and Keil, T. and Lee, Y.A. and Grueters, A. and Krude, H.
PLoS Genetics 8 (3): e1002543. 15 March 2012

MicroRNA expression and regulation in human, chimpanzee, and macaque brains.
Hu, H.Y. and Guo, S. and Xi, J. and Yan, Z. and Fu, N. and Zhang, X. and Menzel, C. and Liang, H. and Yang, H. and Zhao, M. and Zeng, R. and Chen, W. and Paeaebo, S. and Khaitovich, P.
PLoS Genetics 7 (10): e1002327. October 2011

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.
Kruegel, U. and Robison, B. and Dange, T. and Kahlert, G. and Delaney, J.R. and Kotireddy, S. and Tsuchiya, M. and Tsuchiyama, S. and Murakami, C.J. and Schleit, J. and Sutphin, G. and Carr, D. and Tar, K. and Dittmar, G. and Kaeberlein, M. and Kennedy, B.K. and Schmidt, M.
PLoS Genetics 7 (9): e1002253. September 2011

A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in caenorhabditis elegans.
Mansisidor, A.R. and Cecere, G. and Hoersch, S. and Jensen, M.B. and Kawli, T. and Kennedy, L.M. and Chavez, V. and Tan, M.W. and Lieb, J.D. and Grishok, A.
PLoS Genetics 7 (9): e1002299. September 2011

Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes pelizaeus-merzbacher-like disease in humans.
Tress, O. and Maglione, M. and Zlomuzica, A. and May, D. and Dicke, N. and Degen, J. and Dere, E. and Kettenmann, H. and Hartmann, D. and Willecke, K.
PLoS Genetics 7 (7): e1002146. July 2011

The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
Schlesinger, J. and Schueler, M. and Grunert, M. and Fischer, J.J. and Zhang, Q. and Krueger, T. and Lange, M. and Toenjes, M. and Dunkel, I. and Sperling, S.R.
PLoS Genetics 7 (2): e1001313. February 2011

Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level.
Rach, E.A. and Winter, D.R. and Benjamin, A.M. and Corcoran, D.L. and Ni, T. and Zhu, J. and Ohler, U.
PLoS Genetics 7 (1): e1001274. 13 January 2011

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Juerchott, K. and Kuban, R.J. and Krech, T. and Blüthgen, N. and Stein, U. and Walther, W. and Friese, C. and Kielbasa, S.M. and Ungethuem, U. and Lund, P. and Knoesel, T. and Kemmner, W. and Morkel, M. and Fritzmann, J. and Schlag, P.M. and Birchmeier, W. and Krueger, T. and Sperling, S. and Sers, C. and Royer, H.D. and Herzel, H. and Schaefer, R.
PLoS Genetics 6 (12): e1001231. 2 December 2010

Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations.
Rajab, A. and Straub, V. and McCann, L.J. and Seelow, D. and Varon, R. and Barresi, R. and Schulze, A. and Lucke, B. and Luetzkendorf, S. and Karbasiyan, M. and Bachmann, S. and Spuler, S. and Schuelke, M.
PLoS Genetics 6 (3): e1000874. 12 March 2010

A systematic approach to mapping recessive disease genes in individuals from outbred populations.
Hildebrandt, F. and Heeringa, S.F. and Rueschendorf, F. and Attanasio, M. and Nuernberg, G. and Becker, C. and Seelow, D. and Huebner, N. and Chernin, G. and Vlangos, C.N. and Zhou, W. and O'Toole, J.F. and Hoskins, B.E. and Wolf, M.T. and Hinkes, B.G. and Chaib, H. and Ashraf, S. and Allen, S.J. and Vega-Warner, V. and Wise, E. and Harville, H.M. and Lyons, R.H. and Washburn, J. and Macdonald, J. and Nuernberg, P. and Otto, E.A.
PLoS Genetics 5 (1): e1000353. 23 January 2009

Evolution of a core gene network for skeletogenesis in chordates.
Hecht, J. and Stricker, S. and Wiecha, U. and Stiege, A. and Panopoulou, G. and Podsiadlowski, L. and Poustka, A.J. and Dieterich, C. and Ehrich, S. and Suvorova, J. and Mundlos, S. and Seitz, V.
PLoS Genetics 4 (3): e1000025. 21 March 2008

Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region.
Noordermeer, D. and Branco, M.R. and Splinter, E. and Klous, P. and van Ijcken, W. and Swagemakers, S. and Koutsourakis, M. and van der Spek, P. and Pombo, A. and de Laat, W.
PLoS Genetics 4 (3): e1000016. 7 March 2008

Genome-wide linkage analysis of malaria infection intensity and mild disease.
Timmann, C. and Evans, J.A. and Koenig, I.R. and Kleensang, A. and Ruschendorf, F. and Lenzen, J. and Sievertsen, J. and Becker, C. and Enuameh, Y. and Kwakye, K.O. and Opoku, E. and Browne, E.N. and Ziegler, A. and Nurnberg, P. and Horstmann, R.D.
PLoS Genetics 3 (3): 393-400. 23 March 2007

Assessing systems properties of yeast mitochondria through an interaction map of the organelle.
Perocchi, F. and Jensen, L.J. and Gagneur, J. and Ahting, U. and von Mering, C. and Bork, P. and Prokisch, H. and Steinmetz, L.M.
PLoS Genetics 2 (10): 1612-1624. 20 October 2006

Heritability and tissue specificity of expression quantitative trait loci.
Petretto, E. and Mangion, J. and Dickens, N.J. and Cook, S.A. and Kumaran, M.K. and Lu, H. and Fischer, J. and Maatz, H. and Kren, V. and Pravenec, M. and Hubner, N. and Aitman, T.J.
PLoS Genetics 2 (10): 1625-1633. 20 October 2006

Haplotype block structure is conserved across mammals.
Guryev, V. and Smits, B.M. and van de Belt, J. and Verheul, M. and Hubner, N. and Cuppen, E.
PLoS Genetics 2 (7): 1111-1118. 28 July 2006

Complex loci in human and mouse genomes.
Engstroem, P.G. and Suzuki, H. and Ninomiya, N. and Akalin, A. and Sessa, L. and Lavorgna, G. and Brozzi, A. and Luzi, L. and Tan, S.L. and Yang, L. and Kunarso, G. and Ng, E.L.C. and Batalov, S. and Wahlestedt, C. and Kai, C. and Kawai, J. and Carninci, P. and Hayashizaki, Y. and Wells, C. and Bajic, V.B. and Orlando, V. and Reid, J.F. and Lenhard, B. and Lipovich, L.
PLoS Genetics 2 (4): 564-577. 28 April 2006

Editorial

Polycomb targets seek closest neighbours.
Chotalia, M. and Pombo, A.
PLoS Genetics 7 (3): e1002031. March 2011