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2018

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Ruess, D.A. and Heynen, G.J. and Ciecielski, K.J. and Ai, J. and Berninger, A. and Kabacaoglu, D. and Görgülü, K. and Dantes, Z. and Wörmann, S.M. and Diakopoulos, K.N. and Karpathaki, A.F. and Kowalska, M. and Kaya-Aksoy, E. and Song, L. and Zeeuw van der Laan, E.A. and López-Alberca, M.P. and Nazaré, M. and Reichert, M. and Saur, D. and Erkan, M.M. and Hopt, U.T. and Sainz, B. and Birchmeier, W. and Schmid, R.M. and Lesina, M. and Algül, H.
Nature Medicine 24 (7): 954-960. July 2018

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.
Wong, G.S. and Zhou, J. and Liu, J.B. and Wu, Z. and Xu, X. and Li, T. and Xu, D. and Schumacher, S.E. and Puschhof, J. and McFarland, J. and Zou, C. and Dulak, A. and Henderson, L. and Xu, P. and O'Day, E. and Rendak, R. and Liao, W.L. and Cecchi, F. and Hembrough, T. and Schwartz, S. and Szeto, C. and Rustgi, A.K. and Wong, K.K. and Diehl, J.A. and Jensen, K. and Graziano, F. and Ruzzo, A. and Fereshetian, S. and Mertins, P. and Carr, S.A. and Beroukhim, R. and Nakamura, K. and Oki, E. and Watanabe, M. and Baba, H. and Imamura, Y. and Catenacci, D. and Bass, A.J.
Nature Medicine 24 (7): 968-977. July 2018

2016

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Stellos, K. and Gatsiou, A. and Stamatelopoulos, K. and Perisic Matic, L. and John, D. and Lunella, F.F. and Jae, N. and Rossbach, O. and Amrhein, C. and Sigala, F. and Boon, R.A. and Fuertig, B. and Manavski, Y. and You, X. and Uchida, S. and Keller, T. and Boeckel, J.N. and Franco-Cereceda, A. and Maegdefessel, L. and Chen, W. and Schwalbe, H. and Bindereif, A. and Eriksson, P. and Hedin, U. and Zeiher, A.M. and Dimmeler, S.
Nature Medicine 22 (10): 1140-1150. October 2016

2014

Reply to Lrp5 regulation of bone mass and gut serotonin synthesis.
Cui, Y. and Niziolek, P.J. and MacDonald, B.T. and Alenina, N. and Matthes, S. and Jacobsen, C.M. and Conlon, R.A. and Brommage, R. and Powell, D.R. and He, X. and Bader, M. and Williams, B.O. and Warman, M.L. and Robling, A.G.
Nature Medicine 20 (11): 1229-1230. 6 November 2014

Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Rahal, R. and Frick, M. and Romero, R. and Korn, J.M. and Kridel, R. and Chun Chan, F. and Meissner, B. and Bhang, H.E. and Ruddy, D. and Kauffmann, A. and Farsidjani, A. and Derti, A. and Rakiec, D. and Naylor, T. and Pfister, E. and Kovats, S. and Kim, S. and Dietze, K. and Doerken, B. and Steidl, C. and Tzankov, A. and Hummel, M. and Monahan, J. and Morrissey, M.P. and Fritsch, C. and Sellers, W.R. and Cooke, V.G. and Gascoyne, R.D. and Lenz, G. and Stegmeier, F.
Nature Medicine 20 (1): 87-92. January 2014

2013

High-throughput identification of antigen-specific TCRs by TCR gene capture.
Linnemann, C. and Heemskerk, B. and Kvistborg, P. and Kluin, R.J.C. and Bolotin, D.A. and Chen, X. and Bresser, K. and Nieuwland, M. and Schotte, R. and Michels, S. and Gomez-Eerland, R. and Jahn, L. and Hombrink, P. and Legrand, N. and Shu, C.J. and Mamedov, I.Z. and Velds, A. and Blank, C.U. and Haanen, J.B.A.G. and Turchaninova, M.A. and Kerkhoven, R.M. and Spits, H. and Hadrup, S.R. and Heemskerk, M.H.M. and Blankenstein, T. and Chudakov, D.M. and Bendle, G.M. and Schumacher, T.N.M.
Nature Medicine 19 (11): 1534-1541. November 2013

2012

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.
Vom Berg, J. and Prokop, S. and Miller, K.R. and Obst, J. and Kaelin, R.E. and Lopategui-Cabezas, I. and Wegner, A. and Mair, F. and Schipke, C.G. and Peters, O. and Winter, Y. and Becher, B. and Heppner, F.L.
Nature Medicine 18 (12): 1812-1819. December 2012

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Stock, K. and Kumar, J. and Synowitz, M. and Petrosino, S. and Imperatore, R. and Smith, E.S.J. and Wend, P. and Purfuerst, B. and Nuber, U.A. and Gurok, U. and Matyash, V. and Waelzlein, J.H. and Chirasani, S.R. and Dittmar, G. and Cravatt, B.F. and Momma, S. and Lewin, G.R. and Ligresti, A. and De Petrocellis, L. and Cristino, L. and Di Marzo, V. and Kettenmann, H. and Glass, R.
Nature Medicine 18 (8): 1232-1238. August 2012

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing.
Guo, W. and Schafer, S. and Greaser, M.L. and Radke, M.H. and Liss, M. and Govindarajan, T. and Maatz, H. and Schulz, H. and Lincoln, S.E. and Parrish, A.M. and Dauksaite, V. and Vakeel, P. and Klaassen, S. and Gerull, B. and Thierfelder, L. and Regitz-Zagrosek, V. and Hacker, T.A. and Saupe, K.W. and Dec, G.W. and Ellinor, P.T. and MacRae, C.A. and Spallek, B. and Fischer, R. and Perrot, A. and Ozcelik, C. and Saar, K. and Hubner, N. and Gotthardt, M.
Nature Medicine 18 (5): 766-773. May 2012

2011

Lrp5 functions in bone to regulate bone mass.
Cui, Y. and Niziolek, P.J. and Macdonald, B.T. and Zylstra, C.R. and Alenina, N. and Robinson, D.R. and Zhong, Z. and Matthes, S. and Jacobsen, C.M. and Conlon, R.A. and Brommage, R. and Liu, Q. and Mseeh, F. and Powell, D.R. and Yang, Q.M. and Zambrowicz, B. and Gerrits, H. and Gossen, J.A. and He, X. and Bader, M. and Williams, B.O. and Warman, M.L. and Robling, A.G.
Nature Medicine 17 (6): 684-691. June 2011

The Ngal reporter mouse detects the response of the kidney to injury in real time.
Paragas, N. and Qiu, A. and Zhang, Q. and Samstein, B. and Deng, S.X. and Schmidt-Ott, K.M. and Viltard, M. and Yu, W. and Forster, C.S. and Gong, G. and Liu, Y. and Kulkarni, R. and Mori, K. and Kalandadze, A. and Ratner, A.J. and Devarajan, P. and Landry, D.W. and D'Agati, V. and Lin, C.S. and Barasch, J.
Nature Medicine 17 (2): 216-222. February 2011

2010

Transgenic mice with a diverse human T cell antigen receptor repertoire.
Li, L.P. and Lampert, J.C. and Chen, X. and Leitao, C. and Popovic, J. and Mueller, W. and Blankenstein, T.
Nature Medicine 16 (9): 1029-1034. September 2010

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.
Bendle, G.M. and Linnemann, C. and Hooijkaas, A.I. and Bies, L. and de Witte, M.A. and Jorritsma, A. and Kaiser, A.D.M. and Pouw, N. and Debets, R. and Kieback, E. and Uckert, W. and Song, J.Y. and Haanen, J.B.A.G. and Schumacher, T.N.M.
Nature Medicine 16 (5): 565-570, 1p following 570. May 2010

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.
Lamprecht, B. and Walter, K. and Kreher, S. and Kumar, R. and Hummel, M. and Lenze, D. and Koechert, K. and Bouhlel, M.A. and Richter, J. and Soler, E. and Stadhouders, R. and Joehrens, K. and Wurster, K.D. and Callen, D.F. and Harte, M.F. and Giefing, M. and Barlow, R. and Stein, H. and Anagnostopoulos, I. and Janz, M. and Cockerill, P.N. and Siebert, R. and Doerken, B. and Bonifer, C. and Mathas, S.
Nature Medicine 16 (5): 571-579, 1p following 579. May 2010

2009

Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis.
Roepke, T.K. and King, E.C. and Reyna-Neyra, A. and Paroder, M. and Purtell, K. and Koba, W. and Fine, E. and Lerner, D.J. and Carrasco, N. and Abbott, G.W.
Nature Medicine 15 (10): 1186-1194. October 2009

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U. and Prat, A. and Prozorovski, T. and Siffrin, V. and Paterka, M. and Herz, J. and Bendix, I. and Ifergan, I. and Schadock, I. and Mori, M.A. and Van Horssen, J. and Schroeter, F. and Smorodchenko, A. and Han, M.H. and Bader, M. and Steinman, L. and Aktas, O. and Zipp, F.
Nature Medicine 15 (7): 788-793. July 2009

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Machnik, A. and Neuhofer, W. and Jantsch, J. and Dahlmann, A. and Tammela, T. and Machura, K. and Park, J.K. and Beck, F.X. and Mueller, D.N. and Derer, W. and Goss, J. and Ziomber, A. and Dietsch, P. and Wagner, H. and van Rooijen, N. and Kurtz, A. and Hilgers, K.F. and Alitalo, K. and Eckardt, K.U. and Luft, F.C. and Kerjaschki, D. and Titze, J.
Nature Medicine 15 (5): 545-552. May 2009

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein, U. and Walther, W. and Arlt, F. and Schwabe, H. and Smith, J. and Fichtner, I. and Birchmeier, W. and Schlag, P.M.
Nature Medicine 15 (1): 59-67. January 2009

2008

Angiogenesis factors and preeclampsia.
Dechend, R. and Luft, F.C.
Nature Medicine 14 (11): 1187-1188. November 2008

Aggravation of viral hepatitis by platelet-derived serotonin.
Lang, P.A. and Contaldo, C. and Georgiev, P. and El-Badry, A.M. and Recher, M. and Kurrer, M. and Cervantes-Barragan, L. and Ludewig, B. and Calzascia, T. and Bolinger, B. and Merkler, D. and Odermatt, B. and Bader, M. and Graf, R. and Clavien, P.A. and Hegazy, A.N. and Loehning, M. and Harris, N.L. and Ohashi, P.S. and Hengartner, H. and Zinkernagel, R.M. and Lang, K.S.
Nature Medicine 14 (7): 756-761. July 2008

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.
Jones, C.A. and London, N.R. and Chen, H. and Park, K.W. and Sauvaget, D. and Stockton, R.A. and Wythe, J.D. and Suh, W. and Larrieu-Lahargue, F. and Mukouyama, Y.S. and Lindblom, P. and Seth, P. and Frias, A. and Nishiya, N. and Ginsberg, M.H. and Gerhardt, H. and Zhang, K. and Li, D.Y.
Nature Medicine 14 (4): 448-453. April 2008

Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart.
Hauck, L. and Harms, C. and An, J. and Rohne, J. and Gertz, K. and Endres, M. and Dietz, R. and von Harsdorf, R.
Nature Medicine 14 (3): 315-324. March 2008

2006

Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis.
Schuchmann, S. and Schmitz, D. and Rivera, C. and Vanhatalo, S. and Salmen, B. and Mackie, K. and Sipilae, S.T. and Voipio, J. and Kaila, K.
Nature Medicine 12 (7): 817-823. July 2006

2002

Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning.
Faendrich, F. and Lin, X. and Chai, G.X. and Schulze, M. and Ganten, D. and Bader, M. and Holle, J. and Huang, D.S. and Parwaresch, R. and Zavazava, N. and Binas, B.
Nature Medicine 8 : 171-178. 1 February 2002

2001

Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment.
Priller, J. and Fluegel, A. and Wehner, T. and Boentert, M. and Haas, C.A. and Prinz, M. and Fernandez-Klett, F. and Prass, K. and Bechmann, I. and de Boer, B.A. and Frotscher, M. and Kreutzberg, G.W. and Persons, D.A. and Dirnagl, U.
Nature Medicine 7 (12): 1356-1361. 1 December 2001

Adoptive tumor therapy with T lymphocytes enriched through an IFN-gamma capture assay.
Becker, C. and Pohla, H. and Frankenberger, B. and Schueler, T. and Assenmacher, M. and Schendel, D.J. and Blankenstein, T.
Nature Medicine 7 (10): 1159-1162. 1 January 2001

2000

Genetic analysis of chemoresistance in primary murine lymphomas.
Schmitt, C.A. and Rosenthal, C.T. and Lowe, S.W.
Nature Medicine 6 : 1029-1035. 1 September 2000

1998

B cells inhibit induction of T cell-dependent tumor immunity.
Qin, Z.H. and Richter, G. and Schueler, T. and Ibe, S. and Cao, X.T. and Blankenstein, T.
Nature Medicine 4 : 627-630. 1 January 1998

The site-specific correction of genetic defects.
Strauss, M.
Nature Medicine 4 : 274-275. 1 January 1998

1997

Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression.
Bargou, R.C. and Juerchott, K. and Wagener, C. and Bergmann, S. and Metzner, S. and Bommert, K. and Mapara, M.Y. and Winzer, K.J. and Dietel, M. and Doerken, B. and Royer, H.D.
Nature Medicine 3 : 447-450. 1 January 1997

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death.
Sandig, V. and Brand, K. and Herwig, S. and Lukas, J. and Bartek, J. and Strauss, M.
Nature Medicine 3 : 313-319. 1 January 1997

1995

Unrestricted cell cycling and cancer.
Strauss, M. and Lukas, J. and Bartek, J.
Nature Medicine 1 (12): 1245-1246. December 1995

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