Article

TFAP2A orchestrates gene regulatory networks and tubular architecture in kidney outer medullary collecting ducts.
Leiz, Janna ORCID: https://orcid.org/0000-0002-6531-7047, López-Cayuqueo, Karen I. ORCID: https://orcid.org/0000-0001-8409-7345, Cao, Shuang ORCID: https://orcid.org/0000-0001-7195-8193, Gerhardt, Louisa M.S., Hinze, Christian ORCID: https://orcid.org/0000-0003-2526-1621 and Schmidt-Ott, Kai M. ORCID: https://orcid.org/0000-0002-7700-7142
JCI Insight 10 (19): e192361. 8 October 2025

SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis.
Bögershausen, N., Cavdarli, B., Nagai, T., Milev, M.P., Wolff, A., Mehranfar, M., Schmidt, J., Choudhary, D., Gutiérrez-Gutiérrez, Ó., Cyganek, L., Saint-Dic, D., Zibat, A., Köhrer, K., Wollenweber, T.E., Wieczorek, D., Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Borodina, T. ORCID: https://orcid.org/0000-0002-6978-016X, Kaçar, D., Haliloğlu, G., Li, Y., Thiel, C., Sacher, M., Knapik, E.W., Yigit, G. and Wollnik, B.
JCI Insight 10 (9): e173484. 8 May 2025

EBAG9 controls CD8(+) T cell memory formation responding to tumor challenge in mice.
Rehm, A. ORCID: https://orcid.org/0000-0001-7490-1950, Wirges, A. ORCID: https://orcid.org/0000-0001-7038-4503, Hoser, D., Fischer, C. ORCID: https://orcid.org/0000-0003-0329-2435, Herda, S., Gerlach, K., Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693, Willimsky, G. ORCID: https://orcid.org/0000-0002-9693-948X and Hoepken, U.E. ORCID: https://orcid.org/0000-0002-0776-4893
JCI Insight 7 (11): e155534. 8 June 2022

Self-sustaining interleukin-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
Kaiser, R. ORCID: https://orcid.org/0000-0003-1750-3395, Leunig, A. ORCID: https://orcid.org/0000-0002-9179-9203, Pekayvaz, K. ORCID: https://orcid.org/0000-0003-4040-650X, Popp, O. ORCID: https://orcid.org/0000-0001-6240-4666, Joppich, M. ORCID: https://orcid.org/0000-0002-6665-8951, Polewka, V., Escaig, R., Anjum, A. ORCID: https://orcid.org/0000-0002-1976-4102, Hoffknecht, M.L. ORCID: https://orcid.org/0000-0002-5894-0308, Gold, C., Brambs, S., Engel, A., Stockhausen, S., Knottenberg, V., Titova, A., Haji, M., Scherer, C. ORCID: https://orcid.org/0000-0003-2816-6793, Muenchhoff, M., Hellmuth, J.C., Saar, K. ORCID: https://orcid.org/0000-0002-4483-1557, Schubert, B. ORCID: https://orcid.org/0000-0003-3412-1102, Hilgendorff, A. ORCID: https://orcid.org/0000-0002-3725-996X, Schulz, C., Kääb, S. ORCID: https://orcid.org/0000-0001-8824-3581, Zimmer, R. ORCID: https://orcid.org/0000-0003-1439-2327, Hübner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Massberg, S., Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Nicolai, L. ORCID: https://orcid.org/0000-0003-0776-5885 and Stark, K.
JCI Insight 6 (18): e150862. 22 September 2021

Distinctive waves of innate immune response in the retina in experimental autoimmune encephalomyelitis.
Cruz-Herranz, A., Oertel, F.C. ORCID: https://orcid.org/0000-0003-4906-5983, Kim, K. ORCID: https://orcid.org/0000-0003-3667-9900, Cantó, E., Timmons, G., Sin, J.H., Devereux, M., Baker, N., Michel, B., Schubert, R.D., Rani, L., Cordano, C. ORCID: https://orcid.org/0000-0002-1413-0442, Baranzini, S.E. ORCID: https://orcid.org/0000-0003-0067-194X and Green, A.J.
JCI Insight 6 (11): e149228. 8 June 2021

Base editing repairs an SGCA mutation in human primary muscle stem cells.
Escobar, H. ORCID: https://orcid.org/0000-0002-8128-7845, Krause, A. ORCID: https://orcid.org/0000-0001-9515-2477, Keiper, S., Kieshauer, J. ORCID: https://orcid.org/0000-0002-6924-8616, Müthel, S. ORCID: https://orcid.org/0000-0002-3525-8859, García de Paredes, M., Metzler, E. ORCID: https://orcid.org/0000-0003-1735-6364, Kühn, R. ORCID: https://orcid.org/0000-0003-1694-9803, Heyd, F. and Spuler, S. ORCID: https://orcid.org/0000-0002-0155-1117
JCI Insight 6 (10): e145994. 24 May 2021

The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms.
Willmes, D.M., Daniels, M., Kurzbach, A., Lieske, S., Bechmann, N., Schumann, T., Henke, C., El-Agroudy, N.N., Da Costa Goncalves, A.C., Peitzsch, M., Hofmann, A., Kanczkowski, W., Kräker, K. ORCID: https://orcid.org/0000-0002-4032-5382, Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Morawietz, H., Deussen, A., Wagner, M., El-Armouche, A., Helfand, S.L., Bornstein, S.R., de Cabo, R., Bernier, M., Eisenhofer, G., Tank, J., Jordan, J. ORCID: https://orcid.org/0000-0003-4518-0706 and Birkenfeld, A.L.
JCI Insight 6 (2): 136083. 25 January 2021

Transient enlargement of brain ventricles during relapsing-remitting multiple sclerosis and experimental autoimmune encephalomyelitis.
Millward, J.M. ORCID: https://orcid.org/0000-0003-4484-2798, Delgado, P.R. ORCID: https://orcid.org/0000-0003-2009-3024, Smorodchenko, A., Boehmert, L. ORCID: https://orcid.org/0000-0002-8703-3133, Periquito, J. ORCID: https://orcid.org/0000-0003-3702-9264, Reimann, H.M. ORCID: https://orcid.org/0000-0003-1053-9256, Prinz, C. ORCID: https://orcid.org/0000-0003-3330-031X, Els, A., Scheel, M., Bellmann-Strobl, J. ORCID: https://orcid.org/0000-0003-2615-1643, Waiczies, H. ORCID: https://orcid.org/0000-0001-6651-4790, Wuerfel, J. ORCID: https://orcid.org/0000-0002-0034-8053, Infante-Duarte, C. ORCID: https://orcid.org/0000-0003-3005-351X, Chien, C. ORCID: https://orcid.org/0000-0001-8280-9513, Kuchling, J. ORCID: https://orcid.org/0000-0002-7981-2073, Pohlmann, A. ORCID: https://orcid.org/0000-0002-8572-2568, Zipp, F. ORCID: https://orcid.org/0000-0002-1231-1928, Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070, Niendorf, T. ORCID: https://orcid.org/0000-0001-7584-6527 and Waiczies, S. ORCID: https://orcid.org/0000-0002-9916-9572
JCI Insight 5 (21): e140040. 5 November 2020

Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements.
Wang, H., Georgakopoulou, A., Li, C., Liu, Z., Gil, S., Bashyam, A., Yannaki, E., Anagnostopoulos, A., Pande, A. ORCID: https://orcid.org/0009-0008-0826-973X, Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Papayannopoulou, T. and Lieber, A.
JCI Insight 5 (16): e139538. 20 August 2020

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
Dembny, P., Newman, A.G. ORCID: https://orcid.org/0000-0002-0222-9162, Singh, M. ORCID: https://orcid.org/0000-0002-8626-5418, Hinz, M. ORCID: https://orcid.org/0000-0003-2611-4121, Szczepek, M., Krüger, C., Adalbert, R., Dzaye, O., Trimbuch, T. ORCID: https://orcid.org/0000-0001-7512-8955, Wallach, T., Kleinau, G., Derkow, K., Richard, B.C., Schipke, C. ORCID: https://orcid.org/0000-0002-1105-1853, Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129, Stachelscheid, H., Golenbock, D., Peters, O. ORCID: https://orcid.org/0000-0003-0568-2998, Coleman, M., Heppner, F.L., Scheerer, P., Tarabykin, V., Ruprecht, K., Izsvák, Z. ORCID: https://orcid.org/0000-0002-2053-2384, Mayer, J. and Lehnardt, S.
JCI Insight 5 (7): e131093. 9 April 2020

Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart.
Vidal, R. ORCID: https://orcid.org/0000-0003-4217-2014, Wagner, J.U.G., Braeuning, C. ORCID: https://orcid.org/0009-0007-1439-9920, Fischer, C. ORCID: https://orcid.org/0000-0003-0329-2435, Patrick, R., Tombor, L., Muhly-Reinholz, M., John, D., Kliem, M., Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Guimarães-Camboa, N., Harvey, R., Dimmeler, S. and Sauer, S. ORCID: https://orcid.org/0000-0002-4794-3693
JCI Insight 4 (22): e131092. 14 November 2019

Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
Huang, A., Shinde, P.V., Huang, J., Senff, T., Xu, H.C., Margotta, C., Häussinger, D., Willnow, T.E. ORCID: https://orcid.org/0000-0001-9515-7921, Zhang, J., Pandyra, A.A., Timm, J., Weggen, S., Lang, K.S. and Lang, P.A.
JCI Insight 4 (17): e129856. 5 September 2019

Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor.
Ortiz, M.V., Ahmed, S., Burns, M., Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Hollmann, T.J., MacArthur, I., Gunasekera, S., Gaewsky, L., Bradwin, G., Ryan, J., Letai, A., He, Y., Naranjo, A., Chi, Y.Y., LaQuaglia, M., Heaton, T., Cifani, P., Dome, J.S., Gadd, S., Perlman, E., Mullen, E., Steen, H. and Kentsis, A.
JCI Insight 4 (15): e127098. 8 August 2019

Prohibitin promotes dedifferentiation and is a potential therapeutic target in neuroblastoma.
MacArthur, I.C., Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Garcia, H.D. ORCID: https://orcid.org/0000-0002-2578-3350, Ortiz, M.V., Toedling, J. ORCID: https://orcid.org/0000-0003-1471-1295, Klironomos, F., Rolff, J., Eggert, A., Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Kentsis, A. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
JCI Insight 4 (10): e127130. 16 May 2019

Nitric oxide-sensitive guanylyl cyclase stimulation improves experimental heart failure with preserved ejection fraction.
Wilck, N. ORCID: https://orcid.org/0000-0003-3189-5364, Markó, L. ORCID: https://orcid.org/0000-0003-1888-5575, Balogh, A. ORCID: https://orcid.org/0000-0001-8756-747X, Kräker, K. ORCID: https://orcid.org/0000-0002-4032-5382, Herse, F. ORCID: https://orcid.org/0000-0002-9305-8134, Bartolomaeus, H. ORCID: https://orcid.org/0000-0003-4288-3828, Szijártó, I.A. ORCID: https://orcid.org/0000-0002-0796-9450, Gollasch, M. ORCID: https://orcid.org/0000-0003-2797-1934, Reichhart, N., Strauss, O., Heuser, A. ORCID: https://orcid.org/0000-0002-3334-960X, Brockschnieder, D., Kretschmer, A., Lesche, R., Sohler, F., Stasch, J.P., Sandner, P., Luft, F. ORCID: https://orcid.org/0000-0002-8635-1199, Müller, D.N. ORCID: https://orcid.org/0000-0003-3650-5644, Dechend, R. ORCID: https://orcid.org/0000-0001-6636-3080 and Haase, N. ORCID: https://orcid.org/0000-0003-0727-1738
JCI Insight 3 (4): e96006. 22 February 2018

Review

Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development.
Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X and Kentsis, A.
JCI Insight 3 (20): 123172. 18 October 2018

Letter

Endothelial deletion of adipose triglyceride lipase protects against heart failure with preserved ejection fraction.
Schwanbeck, J., Stahnke, M., Eberlein, A., Goeritzer, M., Schulze, A., Pernitsch, D., Kolb, D., Grabner, G.F., Bartolomaeus, T.U.P. ORCID: https://orcid.org/0000-0002-5156-7184, Forslund, S.K. ORCID: https://orcid.org/0000-0003-4285-6993, Gerhardt, H. ORCID: https://orcid.org/0000-0002-3030-0384, Schiattarella, G.G. ORCID: https://orcid.org/0000-0002-7582-7171, Cocera Ortega, L., López-Anguita, N. ORCID: https://orcid.org/0000-0003-3373-7191, Kershaw, E.E., Maatz, H. ORCID: https://orcid.org/0000-0002-9232-6272, Hübner, N. ORCID: https://orcid.org/0000-0002-1218-6223, Zechner, R., Foryst-Ludwig, A. and Kintscher, U.
JCI Insight 10 (5): e187145. 10 March 2025