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Article

Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of adeno-associated virus vectors.
Westhaus, A. and Cabanes Creus, M. and Dilworth, K.L. and Zhu, E. and Salas, D. and Navarro, R.G. and Amaya, A.K. and Scott, A. and Kwiatek, M. and McCorkindale, A.L. and Hayman, T.E. and Frahm, A. and Perocheau, D. and Tran, B.M. and Vincan, E. and Wong, S.L. and Waters, S.A. and Riddiough, G.E. and Perini, M.V. and Wilson, L.O.W. and Baruteau, J. and Diecke, S. and Gonzalez-Aseguinolaza, G. and Santilli, G. and Thrasher, A.J. and Alexander, I.E. and Lisowski, L.
Human Gene Therapy 34 (7-8): 273-288. April 2023

Gene therapy "Made in Germany": a historical perspective, analysis of the status quo, and recommendations for action by the German Society for Gene Therapy.
Büning, H. and Fehse, B. and Ivics, Z. and Kochanek, S. and Koehl, U. and Kupatt, C. and Mussolino, C. and Nettelbeck, D.M. and Schambach, A. and Uckert, W. and Wagner, E. and Cathomen, T.
Human Gene Therapy 32 (19-20): 987-996. 18 October 2021

Generation of Epstein-Barr virus antigen-specific T cell receptors recognizing immunodominant epitopes of LMP1, LMP2A, and EBNA3C for immunotherapy.
Dudaniec, K. and Westendorf, K. and Nössner, E. and Uckert, W.
Human Gene Therapy 32 (17-18): 919-935. 21 September 2021

CD8-specific designed ankyrin repeat proteins improve selective gene delivery into human and primate T lymphocytes.
Frank, A.M. and Weidner, T. and Brynza, J. and Uckert, W. and Buchholz, C.J. and Hartmann, J.
Human Gene Therapy 31 (11-12): 679-691. June 2020

Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR.
Clauss, J. and Obenaus, M. and Miskey, C. and Ivics, Z. and Izsvák, Z. and Uckert, W. and Bunse, M.
Human Gene Therapy 29 (5): 569-584. May 2018

Unbiased identification of T cell receptors targeting immunodominant peptide-MHC complexes for T cell receptor immunotherapy.
Lorenz, F.K.M. and Ellinger, C. and Kieback, E. and Wilde, S. and Lietz, M. and Schendel, D.J. and Uckert, W.
Human Gene Therapy 28 (12): 1158-1168. 1 December 2017

Herpes simplex virus/Sleeping Beauty Vector-based embryonic gene transfer using the HSB5 mutant: loss of apparent transposition hyperactivity in vivo.
de Silva, S. and Mastrangelo, M.A. and Lotta, L.T. and Burris, C.A. and Izsvak, Z. and Ivics, Z. and Bowers, W.J.
Human Gene Therapy 21 (11): 1603-1613. 19 November 2010

Phase I trial of an allogeneic gene-modified tumor cell vaccine (RCC-26/CD80/IL-2) in patients with metastatic renal cell carcinoma.
Buchner, A. and Pohla, H. and Willimsky, G. and Frankenberger, B. and Frank, R. and Baur-Melnyk, A. and Siebels, M. and Stief, C.G. and Hofstetter, A. and Kopp, J. and Pezzutto, A. and Blankenstein, T. and Oberneder, R. and Schendel, D.J.
Human Gene Therapy 21 (3): 285-297. March 2010

Uptake, biodistribution, and time course of naked plasmid DNA trafficking after intratumoral in vivo jet injection.
Walther, W. and Minow, T. and Martin, R. and Fichtner, I. and Schlag, P.M. and Stein, U.
Human Gene Therapy 17 (6): 611-624. 15 June 2006

Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes.
Engels, B. and Noessner, E. and Frankenberger, B. and Blankenstein, T. and Schendel, D.J. and Uckert, W.
Human Gene Therapy 16 (7): 799-810. 1 July 2005

Adenoviral natural born killer gene therapy for malignant glioma.
Naumann, U. and Schmidt, F. and Wick, W. and Frank, B. and Weit, S. and Gillissen, B. and Daniel, P. and Weller, M.
Human Gene Therapy 14 (13): 1235-1246. 1 September 2003

Retroviral vectors for high-level transgene expression in T lymphocytes.
Engels, B. and Cam, H. and Schueler, T. and Indraccolo, S. and Gladow, M. and Baum, C. and Blankenstein, T. and Uckert, W.
Human Gene Therapy 14 (12): 1155-1168. 10 August 2003

Liposomal gene therapy with the herpes simplex thymidine kinase gene/ganciclovir system for the treatment of glioblastoma multiforme.
Voges, J. and Weber, F. and Reszka, R. and Sturm, V. and Jacobs, A. and Heiss, W.D. and Wiestler, O. and Kapp, J.F.
Human Gene Therapy 13 : 675-685. 1 January 2002

A phase I study of intralesional administration of an adenovirus vector expressing the HSV-1 thymidine kinase gene (AdV.RSV-TK) in combination with escalating doses of ganciclovir in patients with cutaneous metastatic malignant melanoma.
Morris, J.C. and Ramsey, W.J. and Wildner, O. and Muslow, H.A. and Aguilar-Cordova, E. and Blaese, R.M.
Human Gene Therapy 11 : 487-503. 10 February 2000

Efficient gene transfer into primary human CD8+ T lymphocytes by MuLV-10A1 retrovirus pseudotype.
Uckert, W. and Becker, C. and Gladow, M. and Klein, D. and Kammertoens, T. and Pedersen, L. and Blankenstein, T.
Human Gene Therapy 11 (7): 1005-1014. 1 January 2000

Liposomal encapsulation of ganciclovir enhances the efficacy of herpes simplex virus type 1 thymidine kinase suicide gene therapy against hepatic tumors in rats.
Engelmann, C. and Panis, Y. and Bolard, J. and Diquet, B. and Fabre, M. and Nagy, H. and Soubrane, O. and Houssin, D. and Klatzmann, D.
Human Gene Therapy 10 : 1545-1551. 10 June 1999

Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection.
Diebold, S.S. and Lehrmann, H. and Kursa, M. and Wagner, E. and Cotten, M. and Zenke, M.
Human Gene Therapy 10 : 775-786. 20 March 1999

Strong immunogenic potential of a B7 retroviral expression vector: Generation of HLA-B7-restricted CTL response against selectable marker genes.
Jung, D. and Jaeger, E. and Cayeux, S. and Blankenstein, T. and Hilmes, C. and Karbach, J. and Moebius, U. and Knuth, A. and Huber, C. and Seliger, B.
Human Gene Therapy 9 : 53-62. 1 January 1998

Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
Uckert, W. and Kammertoens, T. and Haack, K. and Qin, Z. and Gebert, J. and Schendel, D.J. and Blankenstein, T.
Human Gene Therapy 9 : 855-865. 1 January 1998

RNA levels of human retrovirus receptors Pit1 and Pit2 do not correlate with infectibility by three retroviral vector pseudotypes.
Uckert, W. and Willimsky, G. and Pedersen, F.S. and Blankenstein, T. and Pedersen, L.
Human Gene Therapy 9 : 2619-2627. 1 January 1998

Ex vivo breast cancer cell purging by adenovirus- mediated cytosine deaminase gene transfer and short-term incubation with 5-Fluorocytosine completely prevents tumor growth after transplantation.
Wolff, G. and Koerner, I. and Schumacher, A. and Arnold, W. and Doerken, B. and Mapara, M.Y.
Human Gene Therapy 9 : 2277-2284. 1 January 1998

Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract.
Worgall, S. and Leopold, P.L. and Wolff, G. and Ferris, B. and Van Roijen, N. and Crystal, R.G.
Human Gene Therapy 8 (14): 1675-1684. 20 September 1997

Transient expression of SV 40 large T antigen by Cre/LoxP mediated site specific deletion in primary human tumor cells.
Li, L.P. and Schlag, P.M. and Blankenstein, T.
Human Gene Therapy 8 : 1695-1700. 1 January 1997

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.
Worgall, S. and Wolff, G. and Falck-Pedersen, E. and Crystal, R.G.
Human Gene Therapy 8 : 37-44. 1 January 1997

Gene transfer into hepatocytes and human liver tissue by baculovirus vectors.
Sandig, V. and Hofmann, C. and Steinert, S. and Jennings, G. and Schlag, P.M. and Strauss, M.
Human Gene Therapy 7 (16): 1937-1945. 20 October 1996

Coexpression of interleukin-4 and B7.1 in murine tumor cells leads to improved tumor rejection and vaccine effect compared to single gene transfectants and a classical adjuvant.
Cayeux, S. and Beck, C. and Doerken, B. and Blankenstein, T.
Human Gene Therapy 7 (4): 525-529. 1 January 1996

"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype.
Mastrangeli, A. and Harvey, B.G. and Yao, J. and Wolff, G. and Kovesdi, I. and Crystal, R.G. and Falck-Pedersen, E.
Human Gene Therapy 7 (1): 79-87. January 1996

The thymidine kinase/ganciclovir-mediated "suicide" effect is highly variable in different tumor cells.
Beck, C. and Cayeux, S. and Lupton, S. and Doerken, B. and Blankenstein, T.
Human Gene Therapy 6 (12): 1525-1530. 1 January 1995

Review

Wide awake and ready to move: 20 years of non-viral therapeutic genome engineering with the Sleeping Beauty transposon system.
Hodge, R. and Narayanavari, S. and Izsvák, Z. and Ivics, Z.
Human Gene Therapy 28 (10): 842-855. 1 October 2017

Nonviral gene delivery with the Sleeping Beauty transposon system.
Ivics, Z. and Izsvak, Z.
Human Gene Therapy 22 (9): 1043-1051. September 2011

Editorial

Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events.
Buening, H. and Uckert, W. and Cichutek, K. and Hawkins, R.E. and Abken, H.
Human Gene Therapy 21 (9): 1039-1042. September 2010