Browse by Research Team

2023

Single-cell, whole-embryo phenotyping of mammalian developmental disorders.
Huang, X. and Henck, J. and Qiu, C. and Sreenivasan, V.K.A. and Balachandran, S. and Amarie, O.V. and Hrabě de Angelis, M. and Behncke, R.Y. and Chan, W.L. and Despang, A. and Dickel, D.E. and Duran, M. and Feuchtinger, A. and Fuchs, H. and Gailus-Durner, V. and Haag, N. and Hägerling, R. and Hansmeier, N. and Hennig, F. and Marshall, C. and Rajderkar, S. and Ringel, A. and Robson, M. and Saunders, L.M. and da Silva-Buttkus, P. and Spielmann, N. and Srivatsan, S.R. and Ulferts, S. and Wittler, L. and Zhu, Y. and Kalscheuer, V.M. and Ibrahim, D.M. and Kurth, I. and Kornak, U. and Visel, A. and Pennacchio, L.A. and Beier, D.R. and Trapnell, C. and Cao, J. and Shendure, J. and Spielmann, M.
Nature 623 (7988): 772-781. 23 November 2023

2022

Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.
Ringel, A.R. and Szabo, Q. and Chiariello, A.M. and Chudzik, K. and Schöpflin, R. and Rothe, P. and Mattei, A.L. and Zehnder, To. and Harnett, D. and Laupert, V. and Bianco, S. and Hetzel, S. and Glaser, J. and Phan, M.H.Q. and Schindler, M. and Ibrahim, D.M. and Paliou, C. and Esposito, A. and Prada-Medina, C.A. and Haas, S.A. and Giere, P. and Vingron, M. and Wittler, L. and Meissner, A. and Nicodemi, M. and Cavalli, G. and Bantignies, F. and Mundlos, S. and Robson, M.I.
Cell 185 (20): 3689-3704. 29 September 2022

LRFN5 locus structure is associated with autism and influenced by the sex of the individual and locus conversions.
Lybaek, H. and Robson, M. and de Leeuw, N. and Hehir-Kwa, J.Y. and Jeffries, A. and Haukanes, B.I. and Berland, S. and de Bruijn, D. and Mundlos, S. and Spielmann, M. and Houge, G.
Autism research 15 (3): 421-433. 16 March 2022

Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus.
Gjaltema, R.A.F. and Schwämmle, T. and Kautz, P. and Robson, M. and Schöpflin, R. and Ravid Lustig, L. and Brandenburg, L. and Dunkel, I. and Vechiatto, C. and Ntini, E. and Mutzel, V. and Schmiedel, V. and Marsico, A. and Mundlos, S. and Schulz, E.G.
Molecular Cell 82 (1): 190-208.e17. 6 January 2022

2021

Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.
Allou, L. and Balzano, S. and Magg, A. and Quinodoz, M. and Royer-Bertrand, B. and Schöpflin, R. and Chan, W.L. and Speck-Martins, C.E. and Carvalho, D.R. and Farage, L. and Lourenço, C.M. and Albuquerque, R. and Rajagopal, S. and Nampoothiri, S. and Campos-Xavier, B. and Chiesa, C. and Niel-Bütschi, F. and Wittler, L. and Timmermann, B. and Spielmann, M. and Robson, M.I. and Ringel, A. and Heinrich, V. and Cova, G. and Andrey, G. and Prada-Medina, C.A. and Pescini-Gobert, R. and Unger, S. and Bonafé, L. and Grote, P. and Rivolta, C. and Mundlos, S. and Superti-Furga, A.
Nature 592 (7852): 93-98. 1 April 2021

2020

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer, K. and Valieva, M.E. and Ali, S. and Chamorro Gonzalez, R. and Schöpflin, R. and Röefzaad, C. and Bei, Y. and Dorado Garcia, H. and Rodriguez-Fos, E. and Puiggròs, M. and Kasack, K. and Haase, K. and Keskeny, C. and Chen, C.Y. and Kuschel, L.P. and Euskirchen, P. and Heinrich, V. and Robson, M.I. and Rosswog, C. and Toedling, J. and Szymansky, A. and Hertwig, F. and Fischer, M. and Torrents, D. and Eggert, A. and Schulte, J.H. and Mundlos, S. and Henssen, A.G. and Koche, R.P.
Nature Communications 11 (1): 5823. 16 November 2020

The NEMP family supports metazoan fertility and nuclear envelope stiffness.
Tsatskis, Y. and Rosenfeld, R. and Pearson, J.D. and Boswell, C. and Qu, Y. and Kim, K. and Fabian, L. and Mohammad, A. and Wang, X. and Robson, M.I. and Krchma, K. and Wu, J. and Gonçalves, J. and Hodzic, D. and Wu, S. and Potter, D. and Pelletier, L. and Dunham, W.H. and Gingras, A.C. and Sun, Y. and Meng, J. and Godt, D. and Schedl, T. and Ciruna, B. and Choi, K. and Perry, J.R.B. and Bremner, R. and Schirmer, E.C. and Brill, J.A. and Jurisicova, A. and McNeill, H.
Science Advances 6 (35): eabb4591. 28 August 2020

2019

Enhancer hijacking determines intra- and extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer, K. and Valieva, M. and Ali, S. and Chamorro González, R. and Schöpflin, R. and Röefzaad, C. and Bei, Y. and Garcia, H.D. and Rodriguez-Fos, E. and Puiggròs, M. and Kasack, K. and Haase, K. and Kuschel, L.P. and Euskirchen, P. and Heinrich, V. and Robson, M. and Rosswog, C. and Toedling, J. and Szymansky, A. and Hertwig, F. and Fischer, M. and Torrents, D. and Eggert, A. and Schulte, J.H. and Mundlos, S. and Henssen, A.G. and Koche, R.P.
bioRxiv : 2019.12.20.875807. 20 December 2019

Jumping retroviruses nudge TADs apart.
Robson, M.I. and Mundlos, S.
Nature Genetics 51 (9): 1304-1305. September 2019

Regulatory landscaping: how enhancer-promoter communication is sculpted in 3D.
Robson, M.I. and Ringel, A.R. and Mundlos, S.
Molecular Cell 74 (6): 1110-1122. 20 June 2019

2018

Spatial organization of the nucleus compartmentalizes and regulates the genome.
Robson, M.I. and Rizzotto, A. and Schirmer, E.C.
In: Nuclear Pore Complexes in Genome Organization, Function and Maintenance. Springer Cham, 1-34. ISBN 9783319716145 3 February 2018

2017

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments.
Robson, M.I. and de Las Heras, J.I. and Czapiewski, R. and Sivakumar, A. and Kerr, A.R.W. and Schirmer, E.C.
Genome Research 27 (7): 1126-1138. July 2017

Immunohistochemistry on a panel of Emery-Dreifuss muscular dystrophy samples reveals nuclear envelope proteins as inconsistent markers for pathology.
Le Thanh, P. and Meinke, P. and Korfali, N. and Srsen, V. and Robson, M.I. and Wehnert, M. and Schoser, B. and Sewry, C.A. and Schirmer, E.C.
Neuromuscular Disorders 27 (4): 338-351. April 2017

2016

Tissue-specific gene repositioning by muscle nuclear membrane proteins enhances repression of critical developmental genes during myogenesis.
Robson, M.I. and de Las Heras, J.I. and Czapiewski, R. and Lê Thành, P. and Booth, D.G. and Kelly, D.A. and Webb, S. and Kerr, A.R.W. and Schirmer, E.C.
Molecular Cell 62 (6): 834-847. 16 June 2016

Anchoring a leviathan: how the nuclear membrane tethers the genome.
Czapiewski, R. and Robson, M.I. and Schirmer, E.C.
Frontiers in Genetics 7 : 82. 6 May 2016

The application of DamID to identify peripheral gene sequences in differentiated and primary cells.
Robson, M.I. and Schirmer, E.C.
Methods in molecular biology (Clifton, N.J.) 1411 (1411): 359-86. 2016

2015

Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.
Agirre, X. and Castellano, G. and Pascual, M. and Heath, S. and Kulis, M. and Segura, V. and Bergmann, A. and Esteve, A. and Merkel, A. and Raineri, E. and Agueda, L. and Blanc, J. and Richardson, D. and Clarke, L. and Datta, A. and Russiñol, N. and Queirós, A.C. and Beekman, R. and Rodríguez-Madoz, J.R. and San José-Enériz, E. and Fang, F. and Gutiérrez, N.C. and García-Verdugo, J.M. and Robson, M.I. and Schirmer, E.C. and Guruceaga, E. and Martens, J.H.A. and Gut, M. and Calasanz, M.J. and Flicek, P. and Siebert, R. and Campo, E. and Miguel, J.F.S. and Melnick, A. and Stunnenberg, H.G. and Gut, I.G. and Prosper, F. and Martín-Subero, J.I.
Genome Research 25 (4): 478-487. April 2015

2014

Structural basis of Mos1 transposase inhibition by the anti-retroviral drug Raltegravir.
Wolkowicz, U.M. and Morris, E.R. and Robson, M. and Trubitsyna, M. and Richardson, J.M.
ACS Chemical Biology 9 (3): 743-51. 21 March 2014

NETs and cell cycle regulation.
Robson, M.I. and Le Thanh, P. and Schirmer, E.C.
Advances in experimental medicine and biology 773 (773): 165-85. 1 January 2014

2011

The nuclear envelope as a chromatin organizer.
Zuleger, N. and Robson, M.I. and Schirmer, E.C.
Nucleus 2 (5): 339-49. 25 October 2011