2026

HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space.
Silva Ramos, Eduardo ORCID: https://orcid.org/0000-0002-8520-9107, Boeddrich, Annett ORCID: https://orcid.org/0000-0001-9118-050X, Haenig, Christian ORCID: https://orcid.org/0000-0003-1973-7646, Trepte, Philipp ORCID: https://orcid.org/0000-0002-8141-6272, Ammar, Orchid ORCID: https://orcid.org/0009-0003-5341-4434, Secker, Christopher ORCID: https://orcid.org/0000-0002-7222-536X, Popp, Oliver ORCID: https://orcid.org/0000-0001-6240-4666, Ivanov, Andranik ORCID: https://orcid.org/0000-0002-4824-1925, Keith, Brandon, Harding, Rachel J. ORCID: https://orcid.org/0000-0002-1134-391X, Schindler, Franziska ORCID: https://orcid.org/0000-0002-3320-8284, Koudelka, Tomas ORCID: https://orcid.org/0009-0008-2895-6051, Roth, Leonard, Scharek, Nadine, Zenkner, Martina, Neuendorf, Nancy, Golusik, Sabrina, Beetz, Stephanie, Mertins, Philipp ORCID: https://orcid.org/0000-0002-2245-528X, Piazza, Ilaria ORCID: https://orcid.org/0000-0001-5895-6134, Schnoegl, Sigrid and Wanker, Erich E. ORCID: https://orcid.org/0000-0001-8072-1630
bioRxiv : 2026.03.31.715351. 1 April 2026

Fructose-1,6-bisphosphate couples glycolytic activity to cell adhesion.
Hoffmann, Lennart ORCID: https://orcid.org/0009-0005-3511-6892, Duchmann, Marlen, Lazarow, Katina, Huang, Yun-Hsuan, Lukas, Fabian, Lo, Wen-Ting ORCID: https://orcid.org/0000-0001-7904-6834, Feil, Regina, Schmied, Christopher ORCID: https://orcid.org/0000-0003-2058-1124, Lehmann, Martin ORCID: https://orcid.org/0000-0002-8370-6353, Lunn, John E. ORCID: https://orcid.org/0000-0001-8533-3004, Piazza, Ilaria ORCID: https://orcid.org/0000-0001-5895-6134, von Kries, Jens P. ORCID: https://orcid.org/0000-0003-4716-4988, Haucke, Volker ORCID: https://orcid.org/0000-0003-3119-6993 and Maritzen, Tanja ORCID: https://orcid.org/0000-0003-4993-0340
Nature Cell Biology 28 (4): 739-753. April 2026

Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs.
Kabbe, Mukund, Agirre, Eneritz ORCID: https://orcid.org/0000-0002-5012-0305, Carlström, Karl E. ORCID: https://orcid.org/0000-0002-3001-2403, Dumral, Özge ORCID: https://orcid.org/0000-0002-9980-2702, Lor, Yuk Kit, Pohl, Fabio Baldivia ORCID: https://orcid.org/0000-0003-1695-4936, Ruffin, Nicolas ORCID: https://orcid.org/0000-0002-3698-5505, van Bruggen, David, Meijer, Mandy ORCID: https://orcid.org/0000-0003-3314-1224, Seeker, Luise A., Bestard-Cuche, Nadine, Lederer, Alex R., Zhang, Jilin, Ahola, Virpi, Goldman, Steven A., Edström, Erik, Arvidsson, Lisa ORCID: https://orcid.org/0000-0003-2129-5357, Moreira, Tiago Holm, Bartosovic, Marek ORCID: https://orcid.org/0000-0003-2057-6050, Jagodic, Maja ORCID: https://orcid.org/0000-0003-0756-889X, Williams, Anna ORCID: https://orcid.org/0000-0002-6329-382X and Castelo-Branco, Gonçalo ORCID: https://orcid.org/0000-0003-2247-9393
Nature Neuroscience 29 (4): 992-1006. April 2026

The glycolytic signaling metabolite fructose-1,6-bisphosphate shapes cell adhesion and protrusion.
Piazza, Ilaria ORCID: https://orcid.org/0000-0001-5895-6134
[Dataset] 3 February 2026

2025

Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis.
Zheng, Chao, Hervé, Bastien, Meijer, Mandy ORCID: https://orcid.org/0000-0003-3314-1224, Rubio Rodríguez-Kirby, Leslie Ann, Guerreiro Cacais, André Ortlieb, Kukanja, Petra, Kabbe, Mukund, Jimenez-Beristain, Tony, Olsson, Tomas, Agirre, Eneritz and Castelo-Branco, Gonçalo
Nature Neuroscience 28 (12): 2612-2627. December 2025

Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response.
Lafranchi, Lorenzo, Raja, Glancis Luzeena ORCID: https://orcid.org/0000-0002-7672-8597, Arenas, Alberto M. ORCID: https://orcid.org/0000-0002-5995-2968, Spinner, Anna, Shrung, Kovi R., Hornisch, Maximilian ORCID: https://orcid.org/0000-0003-1153-369X, Schlesinger, Dörte, Luzon, Carmen Navarro, Brinkenstråhle, Linus, Shao, Rui, Piazza, Ilaria ORCID: https://orcid.org/0000-0001-5895-6134, Lehtiö, Janne, Branca, Rui M.M. and Elsӓsser, Simon J. ORCID: https://orcid.org/0000-0001-8724-4849
Nucleic Acids Research 53 (20): gkaf1072. 11 November 2025

The Tip60 acetylome is a hallmark of the proliferative state in Drosophila.
Apostolou, Zivkos, Venkatasubramani, Anuroop V. ORCID: https://orcid.org/0000-0003-2119-8741, Kopp, Lara C., Kars, Gizem, Scacchetti, Alessandro, Campos-Sparr, Aline, Schauer, Tamas, Imhof, Axel and Becker, Peter B. ORCID: https://orcid.org/0000-0001-7186-0372
Nucleic Acids Research 53 (20): gkaf1087. 11 November 2025

Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay.
Zhang, Y., Nersisyan, L., Fürst, E. ORCID: https://orcid.org/0000-0001-7101-5347, Alexopoulos, I., Santolaria, C., Huch, S., Bassot, C., Garre, E., Sunnerhagen, P., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134 and Pelechano, V.
Molecular Cell 85 (10): 2017-2031. 15 May 2025

Benchmarking of quantitative proteomics workflows for limited proteolysis mass spectrometry.
Koudelka, T. ORCID: https://orcid.org/0009-0008-2895-6051, Bassot, C. and Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134
Molecular & Cellular Proteomics 24 (4): 100945. April 2025

Regulation of gene expression through protein-metabolite interactions.
Hornisch, M. ORCID: https://orcid.org/0000-0003-1153-369X and Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134
NPJ Metabolic Health and Disease 3 (1): 7. 4 March 2025

2024

Comparison of Xrn1 and Rat1 5′ → 3′ exoribonucleases in budding yeast supports the specific role of Xrn1 in cotranslational mRNA decay.
Pérez-Ortín, J.E. ORCID: https://orcid.org/0000-0002-1992-513X, Jordán-Pla, A., Zhang, Y., Moreno-García, J., Bassot, C., Barba-Aliaga, M., de Campos-Mata, L. ORCID: https://orcid.org/0000-0003-1998-4014, Choder, M., Díez, J., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Pelechano, V. and García-Martínez, J.
Yeast 41 (7): 458-472. July 2024

2023

The potential of cross-linking mass spectrometry in the development of protein-protein interaction modulators.
Ruwolt, M. ORCID: https://orcid.org/0009-0000-7220-406X, Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134 and Liu, F. ORCID: https://orcid.org/0000-0002-2358-549X
Current Opinion in Structural Biology 82 : 102648. October 2023

Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation.
Sporre, E., Karlsen, J., Schriever, K. ORCID: https://orcid.org/0000-0002-3677-5508, Asplund-Samuelsson, J., Janasch, M., Strandberg, L., Karlsson, A., Kotol, D. ORCID: https://orcid.org/0000-0002-5388-3826, Zeckey, L., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Syrén, P.O., Edfors, F. and Hudson, E.P. ORCID: https://orcid.org/0000-0003-1899-7649
Communications Biology 6 (1): 947. 18 September 2023

Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.
Malinovska, L. ORCID: https://orcid.org/0000-0002-8514-4569, Cappelletti, V., Kohler, D., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Tsai, T.H. ORCID: https://orcid.org/0000-0001-5211-2985, Pepelnjak, M., Stalder, P., Dörig, C. ORCID: https://orcid.org/0000-0002-4213-8855, Sesterhenn, F., Elsässer, F., Kralickova, L., Beaton, N., Reiter, L. ORCID: https://orcid.org/0000-0001-5751-3139, de Souza, N., Vitek, O. and Picotti, P.
Nature Protocols 18 : 659-682. 16 March 2023

Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.
Li, B. ORCID: https://orcid.org/0000-0001-8143-4035, Zeis, P. ORCID: https://orcid.org/0000-0001-7615-2201, Zhang, Y., Alekseenko, A., Fürst, E. ORCID: https://orcid.org/0000-0001-7101-5347, Sanchez, Y.P., Lin, G. ORCID: https://orcid.org/0000-0001-9969-8418, Tekkedil, M.M., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Steinmetz, L.M. and Pelechano, V. ORCID: https://orcid.org/0000-0002-9415-788X
Nature Communications 14 (1): 910. 17 February 2023

2021

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.
Cereghetti, G. ORCID: https://orcid.org/0000-0001-7732-9435, Wilson-Zbinden, C., Kissling, V.M. ORCID: https://orcid.org/0000-0002-4524-9905, Diether, M., Arm, A., Yoo, H., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Saad, S. ORCID: https://orcid.org/0000-0003-1062-2906, Picotti, P., Drummond, D.A. ORCID: https://orcid.org/0000-0001-7018-7059, Sauer, U., Dechant, R. ORCID: https://orcid.org/0000-0002-4094-4773 and Peter, M. ORCID: https://orcid.org/0000-0002-2160-6824
Nature Cell Biology 23 (10): 1085-1094. October 2021

Identifying cell-type-specific metabolic signatures using transcriptome and proteome analyses.
Gebert, N., Rahman, S., Lewis, C.A., Ori, A. and Cheng, C.W.
Current Protocols 1 (9): e245. 28 September 2021

The rise of proteome-wide biophysics.
Mateus, A. ORCID: https://orcid.org/0000-0001-6870-0677, Savitski, M.M. ORCID: https://orcid.org/0000-0003-2011-9247 and Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134
Molecular Systems Biology 17 (7): e10442. July 2021

Use of cement suspension as an alternative matrix material for textile-reinforced concrete.
Fürst, R. ORCID: https://orcid.org/0000-0002-4372-5322, Fürst, E. ORCID: https://orcid.org/0000-0001-7101-5347, Vlach, T. ORCID: https://orcid.org/0000-0003-0500-6295, Řepka, J. ORCID: https://orcid.org/0000-0003-2888-3848, Pokorný, M. ORCID: https://orcid.org/0000-0002-5423-7818 and Mózer, V. ORCID: https://orcid.org/0000-0002-8031-4610
Materials 14 (9): 2127. 1 May 2021

Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ.
Cappelletti, V., Hauser, T., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Pepelnjak, M., Malinovska, L., Fuhrer, T., Li, Y., Dörig, C., Boersema, P., Gillet, L., Grossbach, J., Dugourd, A., Saez-Rodriguez, J., Beyer, A., Zamboni, N., Caflisch, A., de Souza, N. and Picotti, P.
Cell 184 (2): 545-559. 21 January 2021

2020

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.
Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Beaton, N., Bruderer, R., Knobloch, T., Barbisan, C., Chandat, L., Sudau, A., Siepe, I. ORCID: https://orcid.org/0000-0001-6661-5313, Rinner, O., de Souza, N., Picotti, P. and Reiter, L. ORCID: https://orcid.org/0000-0001-5751-3139
Nature Communications 11 (1): 4200. 21 August 2020

Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins.
Melnik, A., Cappelletti, V., Vaggi, F., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Tognetti, M., Schwarz, C., Cereghetti, G., Ahmed, M.A., Soste, M., Matlack, K., de Souza, N., Csikasz-Nagy, A. and Picotti, P.
Journal of Proteomics 225 : 103862. 15 August 2020

2019

Chromatin-sensitive cryptic promoters putatively drive expression of alternative protein isoforms in yeast.
Wei, W., Hennig, B.P., Wang, J., Zhang, Y., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Pareja Sanchez, Y., Chabbert, C.D., Adjalley, S.H., Steinmetz, L.M. and Pelechano, V.
Genome Research 29 (12): 1974-1984. December 2019

Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis.
Wild, P., Susperregui, A., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Dörig, C., Oke, A., Arter, M., Yamaguchi, M., Hilditch, A.T., Vuina, K., Chan, K.C., Gromova, T., Haber, J.E., Fung, J.C., Picotti, P. and Matos, J.
Molecular Cell 75 (4): 859-874. 22 August 2019

2018

High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds.
Zampieri, M., Szappanos, B., Buchieri, M.V., Trauner, A., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Picotti, P., Gagneux, S., Borrell, S., Gicquel, B., Lelievre, J., Papp, B. and Sauer, U.
Science Translational Medicine 10 (429): eaal3973. 21 February 2018

A map of protein-metabolite interactions reveals principles of chemical communication.
Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Kochanowski, K., Cappelletti, V., Fuhrer, T., Noor, E., Sauer, U. and Picotti, P.
Cell 172 (1-2): 358-372. 11 January 2018

2017

Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry.
Schopper, S., Kahraman, A., Leuenberger, P., Feng, Y., Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Müller, O., Boersema, P.J. and Picotti, P.
Nature Protocols 12 (11): 2391-2410. November 2017

2014

Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits.
Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Rutkowska, A., Ori, A., Walczak, M., Metz, J., Pelechano, V., Beck, M. and Haering, C.H.
Nature Structural & Molecular Biology 21 (6): 560-568. June 2014

2013

Condensin: crafting the chromosome landscape.
Piazza, I. ORCID: https://orcid.org/0000-0001-5895-6134, Haering, C.H. and Rutkowska, A.
Chromosoma 122 (3): 175-190. June 2013