Browse by Research Team

2023

Generation of an induced pluripotent stem cell line from a Huntington's disease patient with a long HTT-PolyQ sequence.
Miller, D.C. and Lisowski, P. and Genehr, C. and Wanker, E.E. and Priller, J. and Prigione, A. and Diecke, S.
Stem Cell Research 68 : 103056. April 2023

Genome-engineering technologies for modeling and treatment of cystic fibrosis.
Dębczyński, M. and Mojsak, D. and Minarowski, Ł. and Maciejewska, M. and Lisowski, P. and Mróz, R.M.
Advances in Medical Sciences 68 (1): 111-120. March 2023

2022

Mechanisms of IRF2BPL-related disorders and identification of a potential therapeutic strategy.
Sinha Ray, S. and Dutta, D. and Dennys, C. and Powers, S. and Roussel, F. and Lisowski, P. and Glažar, P. and Zhang, X. and Biswas, P. and Caporale, J.R. and Rajewsky, N. and Bickle, M. and Wein, N. and Bellen, H.J. and Likhite, S. and Marcogliese, P.C. and Meyer, K.C.
Cell Reports 41 (10): 111751. 6 December 2022

Generation of induced pluripotent stem cells from three individuals with Huntington's disease.
Miller, D.C. and Lisowski, P. and Lickfett, S. and Mlody, B. and Bünning, M. and Genehr, C. and Ulrich, C. and Wanker, E.E. and Diecke, S. and Priller, J. and Prigione, A.
Stem Cell Research 65 : 102976. December 2022

Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington's disease models.
Metzger, J.J. and Pereda, C. and Adhikari, A. and Haremaki, T. and Galgoczi, S. and Siggia, E.D. and Brivanlou, A.H. and Etoc, F.
Cell Reports Methods 2 (9): 100297. 19 September 2022

Deletion in the Y chromosome of B10.BR-Y(del) mice alters transcription from MSYq genes and has moderate effect on DNA methylation.
Kotarska, K. and Doniec, A. and Korostyński, M. and Piechota, M. and Gołas, A. and Lisowski, P. and Styrna, J.
Reproductive Biology 22 (2): 100614. June 2022

2021

Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects.
Galgoczi, S. and Ruzo, A. and Markopoulos, C. and Yoney, A. and Phan-Everson, T. and Li, S. and Haremaki, T. and Metzger, J.J. and Etoc, F. and Brivanlou, A.H.
Development 148 (19): dev199513. October 2021

Depletion of aneuploid cells in human embryos and gastruloids.
Yang, M. and Rito, T. and Metzger, J. and Naftaly, J. and Soman, R. and Hu, J. and Albertini, D.F. and Barad, D.H. and Brivanlou, A.H. and Gleicher, N.
Nature Cell Biology 23 (4): 314-321. April 2021

Evaluation of aggression and fearfulness in domestic dog (Canis familiaris).
Dyjak, M. and Boruta, A. and Adamkiewicz, E. and Walasek, A. and Bury-Burzymski, P. and Lisowski, P.
Animal Science Papers and Reports 39 (4): 407-418. 2021

2019

Self-organizing neuruloids model developmental aspects of Huntington's disease in the ectodermal compartment.
Haremaki, T. and Metzger, J.J. and Rito, T. and Ozair, M.Z. and Etoc, F. and Brivanlou, A.H.
Nature Biotechnology 37 (10): 1198-1208. October 2019

A 3D model of a human epiblast reveals BMP4-driven symmetry breaking.
Simunovic, M. and Metzger, J.J. and Etoc, F. and Yoney, A. and Ruzo, A. and Martyn, I. and Croft, G. and You, D.S. and Brivanlou, A.H. and Siggia, E.D.
Nature Cell Biology 21 (7): 900-910. July 2019

2018

WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.
Yoney, A. and Etoc, F. and Ruzo, A. and Carroll, T. and Metzger, J.J. and Martyn, I. and Li, S. and Kirst, C. and Siggia, E.D. and Brivanlou, A.H.
eLife 7 : e3827. 13 November 2018

Synthetic embryology: controlling geometry to model early mammalian development.
Metzger, J.J. and Simunovic, M. and Brivanlou, A.H.
Current Opinion in Genetics & Development 52 : 86-91. October 2018

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning.
Morgani, S.M. and Metzger, J.J. and Nichols, J. and Siggia, E.D. and Hadjantonakis, A.K.
eLife 7 : e32839. 7 February 2018

Chromosomal instability during neurogenesis in Huntington's disease.
Ruzo, A. and Croft, G.F. and Metzger, J.J. and Galgoczi, S. and Gerber, L.J. and Pellegrini, C. and Wang, H. and Fenner, M. and Tse, S. and Marks, A. and Nchako, C. and Brivanlou, A.H.
Development 145 (2) January 2018

2017

A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use.
Gleicher, N. and Metzger, J. and Croft, G. and Kushnir, V.A. and Albertini, D.F. and Barad, D.H.
Reproductive Biology and Endocrinology 15 (1): 33. 27 April 2017

Channeling of branched flow in weakly scattering anisotropic media.
Degueldre, H. and Metzger, J.J. and Schultheis, E. and Fleischmann, R.
Physical Review Letters 118 (2): 024301. 13 January 2017

2016

A balance between secreted inhibitors and edge sensing controls gastruloid self-organization.
Etoc, F. and Metzger, J. and Ruzo, A. and Kirst, C. and Yoney, A. and Ozair, M.Z. and Brivanlou, A.H. and Siggia, E.D.
Developmental Cell 39 (3): 302-315. 7 November 2016

Self-organization of human embryonic stem cells on micropatterns.
Deglincerti, A. and Etoc, F. and Guerra, M.C. and Martyn, I. and Metzger, J. and Ruzo, A. and Simunovic, M. and Yoney, A. and Brivanlou, A.H. and Siggia, E. and Warmflash, A.
Nature Protocols 11 (11): 2223-2232. November 2016

Non-equilibrium steady states of stochastic processes with intermittent resetting.
Eule, S. and Metzger, J.J.
New Journal of Physics 18 (3): 033006. March 2016

Random focusing of tsunami waves.
Degueldre, H. and Metzger, J.J. and Geisel, T. and Fleischmann, R.
Nature Physics 12 (3): 259-262. March 2016

2014

Statistics of extreme waves in random media.
Metzger, J.J. and Fleischmann, R. and Geisel, T.
Physical Review Letters 112 (20): 203903. 23 May 2014

2013

Experimental observation of a fundamental length scale of waves in random media.
Barkhofen, S. and Metzger, J.J. and Fleischmann, R. and Kuhl, U. and Stöckmann, H.J.
Physical Review Letters 111 (18): 183902. 1 November 2013

Distribution of the fittest individuals and the rate of Muller's ratchet in a model with overlapping generations.
Metzger, J.J. and Eule, S.
PLoS Computational Biology 9 (11): e1003303. November 2013

Intensity fluctuations of waves in random media: what is the semiclassical limit?
Metzger, J.J. and Fleischmann, R. and Geisel, T.
Physical Review Letters 111 (1): 013901. 5 July 2013

2012

How branching can change the conductance of ballistic semiconductor devices.
Maryenko, D. and Ospald, F. and von Klitzing, K. and Smet, J.H. and Metzger, J.J. and Fleischmann, R. and Geisel, T. and Umansky, V.
Physical Review B 85 (19): 195329. 31 May 2012

Random caustics and intensity fluctuations in weakly disordered media.
Fleischmann, R. and Metzger, J. and Geisel, T.
In: Frontiers in Optics 2012/Laser Science XXVIII, 14-18 Oct 2012, Rochester, NY, USA. 2012

2010

Universal statistics of branched flows.
Metzger, J.J. and Fleischmann, R. and Geisel, T.
Physical Review Letters 105 (2): 020601. 9 July 2010