Cancer Cell

Tumor stroma-derived TGF-beta limits Myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann, M. ORCID: https://orcid.org/0000-0002-7876-0128, Lee, S. ORCID: https://orcid.org/0000-0002-4614-2931, Loddenkemper, C., Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Tabor, V., Aichele, P., Stein, H., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Jenuwein, T. and Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226
Cancer Cell 17 (3): 262-272. 16 March 2010

Cancer Discovery

Extrachromosomal DNA-driven oncogene dosage heterogeneity promotes rapid adaptation to therapy in MYCN-amplified cancers.
Montuori, Giulia, Tu, Fengyu, Qin, Di ORCID: https://orcid.org/0000-0002-9730-4072, Schmargon, Rachel ORCID: https://orcid.org/0009-0009-3535-7185, Rodriguez-Fos, Elias ORCID: https://orcid.org/0000-0002-2555-0178, Helmsauer, Konstantin ORCID: https://orcid.org/0000-0003-0773-4114, Hui, Hui, Mandal, Susmita, Purshouse, Karin, Fankhänel, Lara, Bosco, Bartolomeo ORCID: https://orcid.org/0000-0002-3069-714X, Spanjaard, Bastiaan ORCID: https://orcid.org/0000-0003-1309-8839, Seyboldt, Hannah, Grunewald, Laura, Schmitt, Matthias Jürgen ORCID: https://orcid.org/0000-0001-8296-5858, Gürgen, Dennis, Buck, Viktoria, Rosenfeldt, Mathias T, Dubois, Frank P.B. ORCID: https://orcid.org/0000-0002-7654-6208, Schallenberg, Simon, Lehmann, Annika, Theißen, Jessica, Taschner-Mandl, Sabine, Koch, Arend, Hundsdoerfer, Patrick, Künkele, Annette, Eggert, Angelika, Fischer, Matthias, Gargiulo, Gaetano ORCID: https://orcid.org/0000-0001-5414-4251, Krieger, Teresa G, Chavez, Lukas, Coscia, Fabian ORCID: https://orcid.org/0000-0002-2244-5081, Werner, Benjamin, Huang, Weini, Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X and Dörr, Jan R. ORCID: https://orcid.org/0000-0002-4927-6548
Cancer Discovery 15 (10): 2054-2077. 6 October 2025

Passenger gene coamplifications create collateral therapeutic vulnerabilities in cancer.
Bei, Y. ORCID: https://orcid.org/0000-0002-2104-8025, Brame, Luca ORCID: https://orcid.org/0000-0001-5316-2992, Kirchner, M. ORCID: https://orcid.org/0000-0002-7049-534X, Fritsche-Guenther, R. ORCID: https://orcid.org/0000-0002-6965-0226, Kunz, S. ORCID: https://orcid.org/0000-0002-0131-3506, Bhattacharya, A. ORCID: https://orcid.org/0000-0003-3733-7670, Rusu, M.C. ORCID: https://orcid.org/0000-0002-8369-3580, Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Dubois, F.P.B. ORCID: https://orcid.org/0000-0002-7654-6208, Köppke, J.K.C. ORCID: https://orcid.org/0000-0002-1293-7250, Proba, J. ORCID: https://orcid.org/0009-0006-8293-1248, Wittstruck, N. ORCID: https://orcid.org/0009-0000-4378-3226, Sidorova, O.A. ORCID: https://orcid.org/0009-0004-1459-1662, Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Dorado Garcia, H. ORCID: https://orcid.org/0000-0002-2578-3350, Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Xu, R. ORCID: https://orcid.org/0000-0002-5618-246X, Giurgiu, M. ORCID: https://orcid.org/0000-0001-5007-7442, Rodriguez-Fos, E. ORCID: https://orcid.org/0000-0002-2555-0178, Yu, Q. ORCID: https://orcid.org/0000-0002-2151-9624, Spanjaard, B. ORCID: https://orcid.org/0000-0003-1309-8839, Koche, R.P. ORCID: https://orcid.org/0000-0002-6820-5083, Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226, Schulte, J.H. ORCID: https://orcid.org/0000-0003-0671-1201, Eggert, A. ORCID: https://orcid.org/0000-0003-3476-8184, Haase, K. ORCID: https://orcid.org/0000-0002-0944-5618, Kirwan, J. ORCID: https://orcid.org/0000-0002-5423-1651, Hagemann, A.I. ORCID: https://orcid.org/0000-0001-5491-4607, Mertins, P. ORCID: https://orcid.org/0000-0002-2245-528X, Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548 and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
Cancer Discovery 14 (3): 492-507. 1 March 2024

Children

Germline mutations including the rare pathogenic variant c.3206delC in the ATM gene cause ataxia teleangiectasia-associated primary central nervous system lymphoma.
Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Thorwarth, A., Mizia-Malarz, A. ORCID: https://orcid.org/0000-0002-1984-5527, Radke, J. ORCID: https://orcid.org/0000-0001-9860-2007, Tietze, A., Hernáiz-Driever, P. ORCID: https://orcid.org/0000-0003-3135-3872, Horn, D., Gratopp, A., Eggert, A. and Deubzer, H.E. ORCID: https://orcid.org/0000-0002-6115-4893
Children 8 (6): 469. June 2021

Genes & Development

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.
Jing, H., Kase, J., Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Milanovic, M. ORCID: https://orcid.org/0000-0003-1860-6003, Lenze, D., Grau, M., Beuster, G., Ji, S., Reimann, M. ORCID: https://orcid.org/0000-0002-7876-0128, Lenz, P., Hummel, M., Doerken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Lenz, G., Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129, Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226 and Lee, S. ORCID: https://orcid.org/0000-0002-4614-2931
Genes & Development 25 (20): 2137-2146. 15 October 2011

Molecular Cancer Therapeutics

CD20-targeting immunotherapy promotes cellular senescence in B-cell lymphoma.
Däbritz, J.H.M., Yu, Y. ORCID: https://orcid.org/0000-0003-1928-2514, Milanovic, M. ORCID: https://orcid.org/0000-0003-1860-6003, Schönlein, M., Rosenfeldt, M.T., Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Kaufmann, A.M., Dörken, B. ORCID: https://orcid.org/0000-0001-7991-3643 and Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226
Molecular Cancer Therapeutics 15 (5): 1074-1081. May 2016

Nature

Coordinated inheritance of extrachromosomal DNAs in cancer cells.
Hung, K.L. ORCID: https://orcid.org/0000-0002-3662-4662, Jones, M.G., Wong, I.T.L. ORCID: https://orcid.org/0000-0002-9761-3422, Curtis, E.J., Lange, J.T., He, B.J. ORCID: https://orcid.org/0000-0001-8989-1521, Luebeck, J. ORCID: https://orcid.org/0000-0003-4391-979X, Schmargon, R. ORCID: https://orcid.org/0009-0009-3535-7185, Scanu, E., Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Yan, X. ORCID: https://orcid.org/0000-0002-4846-8812, Li, R. ORCID: https://orcid.org/0000-0002-3085-5267, Gnanasekar, A., Chamorro González, R. ORCID: https://orcid.org/0000-0002-5653-7259, Belk, J.A. ORCID: https://orcid.org/0000-0003-4724-6158, Liu, Z., Melillo, B. ORCID: https://orcid.org/0000-0002-9708-5287, Bafna, V., Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Werner, B. ORCID: https://orcid.org/0000-0002-6857-8699, Huang, W. ORCID: https://orcid.org/0000-0002-9016-2665, Cravatt, B.F. ORCID: https://orcid.org/0000-0001-5330-3492, Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X, Mischel, P.S ORCID: https://orcid.org/0000-0002-4560-2211 and Chang, H.Y. ORCID: https://orcid.org/0000-0002-9459-4393
Nature 635 (8037): 201-209. 7 November 2024

Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M. ORCID: https://orcid.org/0000-0003-1860-6003, Fan, D.N.Y. ORCID: https://orcid.org/0000-0001-6826-7076, Belenki, D. ORCID: https://orcid.org/0000-0002-9004-9849, Däbritz, J.H.M., Zhao, Z., Yu, Y. ORCID: https://orcid.org/0000-0003-1928-2514, Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Dimitrova, L., Lenze, D., Monteiro Barbosa, I.A., Mendoza-Parra, M.A., Kanashova, T. ORCID: https://orcid.org/0000-0001-8841-5785, Metzner, M., Pardon, K., Reimann, M. ORCID: https://orcid.org/0000-0002-7876-0128, Trumpp, A., Dörken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Zuber, J., Gronemeyer, H., Hummel, M., Dittmar, G. ORCID: https://orcid.org/0000-0003-3647-8623, Lee, S. ORCID: https://orcid.org/0000-0002-4614-2931 and Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226
Nature 553 (7686): 96-100. 4 January 2018

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Yu, Y. ORCID: https://orcid.org/0000-0003-1928-2514, Milanovic, M. ORCID: https://orcid.org/0000-0003-1860-6003, Beuster, G., Zasada, C. ORCID: https://orcid.org/0000-0003-1547-8317, Däbritz, J.H.M., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfürst, B. ORCID: https://orcid.org/0000-0002-9887-7577, Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U. ORCID: https://orcid.org/0000-0002-8485-1958, Buck, A.K., Dörken, B. ORCID: https://orcid.org/0000-0001-7991-3643, Willmitzer, L., Reimann, M. ORCID: https://orcid.org/0000-0002-7876-0128, Kempa, S. ORCID: https://orcid.org/0000-0002-0696-9299, Lee, S. ORCID: https://orcid.org/0000-0002-4614-2931 and Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226
Nature 501 (7467): 421-425. 19 September 2013

Nature Communications

Senescence-associated lineage-aberrant plasticity evokes T-cell-mediated tumor control.
Belenki, D. ORCID: https://orcid.org/0000-0002-9004-9849, Richter-Pechanska, P. ORCID: https://orcid.org/0000-0001-6727-6317, Shao, Z., Bhattacharya, A. ORCID: https://orcid.org/0000-0003-3733-7670, Lau, A., de Freitas, J.A.N.L.F. ORCID: https://orcid.org/0000-0003-3689-765X, Kandler, G., Hick, T.P., Cai, X., Scharnagl, Eva, Bittner, A. ORCID: https://orcid.org/0000-0001-6434-0950, Schönlein, M., Kase, J., Pardon, K., Brzezicha, B., Thiessen, N., Bischof, O. ORCID: https://orcid.org/0000-0003-2422-6277, Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Reimann, M. ORCID: https://orcid.org/0000-0002-7876-0128, Milanovic, M. ORCID: https://orcid.org/0000-0003-1860-6003, Du, J., Yu, Y. ORCID: https://orcid.org/0000-0003-1928-2514, Chapuy, B. ORCID: https://orcid.org/0000-0002-6485-8773, Lee, S. ORCID: https://orcid.org/0000-0002-4614-2931, Leser, U., Scheidereit, C. ORCID: https://orcid.org/0000-0002-0446-6129, Wolf, J. ORCID: https://orcid.org/0000-0003-3254-5868, Fan, D.N.Y. ORCID: https://orcid.org/0000-0001-6826-7076 and Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226
Nature Communications 16 (1): 3079. 31 March 2025

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.
Schleich, K., Kase, J., Dörr, J.R. ORCID: https://orcid.org/0000-0002-4927-6548, Trescher, S., Bhattacharya, A. ORCID: https://orcid.org/0000-0003-3733-7670, Yu, Y. ORCID: https://orcid.org/0000-0003-1928-2514, Wailes, E.M., Fan, D.N.Y. ORCID: https://orcid.org/0000-0001-6826-7076, Lohneis, P., Milanovic, M. ORCID: https://orcid.org/0000-0003-1860-6003, Lau, A., Lenze, D., Hummel, M., Chapuy, B., Leser, U., Reimann, M. ORCID: https://orcid.org/0000-0002-7876-0128, Lee, S. ORCID: https://orcid.org/0000-0002-4614-2931 and Schmitt, C.A. ORCID: https://orcid.org/0000-0002-4731-2226
Nature Communications 11 (1): 3651. 20 July 2020

bioRxiv

Extrachromosomal DNA micronucleation constrains tumour fitness and improves patient survival.
Brückner, L. ORCID: https://orcid.org/0000-0002-6155-2277, Xu, R. ORCID: https://orcid.org/0000-0002-5618-246X, Tang, J., Gnanasekar, A., Herrmann, A., Wong, I.T.L., Zhang, S., Tu, F., Pilon, M., Kukalev, A. ORCID: https://orcid.org/0000-0001-5847-3773, Pardon, K., Sidorova, O. ORCID: https://orcid.org/0009-0004-1459-1662, Atta, J., Yu, Q. ORCID: https://orcid.org/0000-0002-2151-9624, Montouri, G., Pradella, D., Ilić, M., Suina, K., Novais-Cruz, M., Kaltenbach, S., Treue, D., Giurgiu-Kraljič, M. ORCID: https://orcid.org/0000-0001-5007-7442, Herzog, S., Hollinger, A.S., Wittstruck, N., Fernandez, M., Wolozyn, N., Becker, F., Louma, V.R., Yan, X., Schmargon, R. ORCID: https://orcid.org/0009-0009-3535-7185, Dörr, J. ORCID: https://orcid.org/0000-0002-4927-6548, Gamlin, D., Lehmann, A., Gürgen, D. ORCID: https://orcid.org/0000-0001-9241-6537, Richter, M. ORCID: https://orcid.org/0000-0002-5339-0781, Dubois, F. ORCID: https://orcid.org/0000-0002-7654-6208, Simeoni, F., Pennycook, B.R., Hamilton, A., Lindemann, R.K., Dawes, C., Balmus, G., Hero, B., Fischer, M., Bafna, V., Verhaak, R., Wahl, G., Liu, Y., Koche, R.P., Papathanasiou, S., Medema, R., Spanjaard, B. ORCID: https://orcid.org/0000-0003-1309-8839, Ventura, A., Pombo, A. ORCID: https://orcid.org/0000-0002-7493-6288, Huang, W., Scheer, M., Werner, B., Chang, H.Y., Mischel, P.S. and Henssen, A.G. ORCID: https://orcid.org/0000-0003-1534-778X
bioRxiv : 2025.04.15.648906. 19 February 2026