Article

Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.
Wang, Yinuo ORCID: https://orcid.org/0000-0002-6653-6014, Shi, Haojie, Wittig, Janina ORCID: https://orcid.org/0009-0002-6091-7569, Ren, Yonggang, Cordero, Julio ORCID: https://orcid.org/0000-0002-2136-1783, Dewenter, Matthias, Mella, Jessica, Buchwalter, Abigail ORCID: https://orcid.org/0000-0001-7181-6961, Backs, Johannes ORCID: https://orcid.org/0000-0002-2322-2699, Wieland, Thomas ORCID: https://orcid.org/0000-0001-8262-8261, Heineke, Joerg ORCID: https://orcid.org/0000-0002-1541-3030, Fleming, Ingrid ORCID: https://orcid.org/0000-0003-1881-3635, Bibli, Sofia-Iris ORCID: https://orcid.org/0000-0001-7153-6628 and Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416
Nature Metabolism 8 (2): 431-453. February 2026

Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation.
Drekolia, Maria-Kyriaki, Mettner, Janina, Wang, Daiyu, Delgado Lagos, Fredy, Koch, Christian, Hecker, Dennis, Eresch, Jeanette, Mao, Yifang, Bähr, Marion, Weichenhan, Dieter, Cordero, Julio, Wittig, Janina, Zhang, Boran, Cui, Hanyu, Li, Xiaoming, Oo, James A., Weigert, Andreas, Siragusa, Mauro, Klatt, Stephan, Fleming, Ingrid, Günther, Stefan, Looso, Mario, Brandes, Ralf P., Langer, Harald F., Papapetropoulos, Andreas, Singhal, Mahak ORCID: https://orcid.org/0000-0002-7303-9585, Schulz, Marcel H., Plass, Christoph, Heineke, Joerg, Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416, Hu, Jiong and Bibli, Sofia-Iris
Cell Metabolism 38 (1): 115-134.e20. 6 January 2026

Endothelial RNF20 suppresses endothelial-to-mesenchymal transition and safeguards physiological angiocrine signaling to prevent congenital heart disease.
Dou, Yanliang, Tetik-Elsherbiny, Nalan ORCID: https://orcid.org/0009-0005-6537-6783, Gao, Rui ORCID: https://orcid.org/0009-0006-1400-4637, Ren, Yonggang, Chen, Yu-Wen, Merbecks, Moritz, Setya, Aadhyaa, Lityagina, Olga, Wang, Yinuo ORCID: https://orcid.org/0000-0002-6653-6014, Chichelnitskiy, Evgeny, Abouissa, Aya ORCID: https://orcid.org/0000-0002-8325-0296, Wu, Chi-Chung ORCID: https://orcid.org/0000-0003-3903-2512, Barreto, Guillermo ORCID: https://orcid.org/0000-0002-7777-4712, Potente, Michael ORCID: https://orcid.org/0000-0002-5689-0036, Wieland, Thomas ORCID: https://orcid.org/0000-0001-8262-8261, Ola, Roxana ORCID: https://orcid.org/0000-0002-2566-4431, Grieshaber, Philippe, Loukanov, Tsvetomir, Gorenflo, Matthias, Heineke, Joerg ORCID: https://orcid.org/0000-0002-1541-3030, Cordero, Julio ORCID: https://orcid.org/0000-0002-2136-1783 and Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416
Nature Communications 16 (1): 9480. 27 October 2025

RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α.
Liu, H., Tang, Y., Singh, A., Vong, J. ORCID: https://orcid.org/0000-0002-5859-2008, Cordero, J., Mathes, A., Gao, R. ORCID: https://orcid.org/0009-0006-1400-4637, Jia, Y., Garvalov, B.K. ORCID: https://orcid.org/0000-0003-0013-9064, Acker, T. ORCID: https://orcid.org/0000-0001-6357-7227, Poschet, G., Hell, R. ORCID: https://orcid.org/0000-0002-6238-4818, Schneider, M.A. ORCID: https://orcid.org/0000-0001-8269-3821, Heineke, J. ORCID: https://orcid.org/0000-0002-1541-3030, Wieland, T. ORCID: https://orcid.org/0000-0001-8262-8261, Barreto, G. ORCID: https://orcid.org/0000-0002-7777-4712, Cerwenka, A. ORCID: https://orcid.org/0000-0001-6977-3536, Potente, M. ORCID: https://orcid.org/0000-0002-5689-0036, Bibli, S.I., Savai, R. ORCID: https://orcid.org/0000-0003-1538-2091 and Dobreva, G. ORCID: https://orcid.org/0000-0002-4814-9416
Nature Communications 16 (1): 4929. 28 May 2025

Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription.
Cordero, J., Swaminathan, G. ORCID: https://orcid.org/0009-0005-4727-2032, Rogel-Ayala, D.G. ORCID: https://orcid.org/0009-0004-3343-286X, Rubio, K., Elsherbiny, A., Mahmood, S., Szymanski, W. ORCID: https://orcid.org/0000-0002-1202-3299, Graumann, J. ORCID: https://orcid.org/0000-0002-3015-5850, Braun, T. ORCID: https://orcid.org/0000-0002-6165-4804, Günther, S. ORCID: https://orcid.org/0000-0002-5594-4549, Dobreva, G. ORCID: https://orcid.org/0000-0002-4814-9416 and Barreto, G. ORCID: https://orcid.org/0000-0002-7777-4712
Nature Communications 15 (1): 10711. 20 December 2024

RNF20-mediated transcriptional pausing and VEGFA splicing orchestrate vessel growth.
Tetik-Elsherbiny, N. ORCID: https://orcid.org/0009-0005-6537-6783, Elsherbiny, A., Setya, A., Gahn, J. ORCID: https://orcid.org/0000-0002-9066-0664, Tang, Y., Gupta, P., Dou, Y., Serke, H., Wieland, T. ORCID: https://orcid.org/0000-0001-8262-8261, Dubrac, A., Heineke, J. ORCID: https://orcid.org/0000-0002-1541-3030, Potente, M. ORCID: https://orcid.org/0000-0002-5689-0036, Cordero, J., Ola, R. ORCID: https://orcid.org/0000-0002-2566-4431 and Dobreva, G. ORCID: https://orcid.org/0000-0002-4814-9416
Nature Cardiovascular Research 3 (10): 1199-1216. October 2024

Preprint

Loss of cardiomyocyte eukaryotic elongation factor 1A2 in mice triggers cardiomyopathy due to defective proteostasis.
Martin-Garrido, Abel, Weyrauch, Nadine, Ruiz-Orera, Jorge ORCID: https://orcid.org/0000-0002-8317-0034, Eresch, Jeanette, Reitter, Sonja, Cordero, Julio, Senger, Frauke, Scheich, Viktoria, Grund, Andrea, Keles, Merve ORCID: https://orcid.org/0000-0002-5212-3753, Weinzierl, Nina, Hofmann, Ellen, Trogisch, Felix A., Hemanna, Shruthi, Buettner, Michael, Poschet, Gernot, Rettel, Mandy, Stein, Frank, Rog-Zielinska, Eva A., Frey, Norbert, Stoecklin, Georg, Voelkers, Mirko, Hubner, Norbert ORCID: https://orcid.org/0000-0002-1218-6223, Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416 and Heineke, Joerg ORCID: https://orcid.org/0000-0002-1541-3030
bioRxiv : 2026.01.14.699518v2. 18 February 2026

Ferroptosis governs lymphatic vessel growth and regression.
Drekolia, Maria-Kyriaki, Wang, Daiyu, Chen, Yunyun, Du, Yali, Wittig, Janina, Xu, Ran, Schilling, Danny, Aliraj, Blerina, Mettner, Janina, Gupta, Lavanya, Xu, Cong, Günther, Stefan, Cetin, Ronay, Matthess, Yves, Fleming, Ingrid, Kaulich, Manuel ORCID: https://orcid.org/0000-0002-9528-8822, Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416, Weigert, Andreas, Dick, Tobias P., Dikic, Ivan, Stolz, Alexandra ORCID: https://orcid.org/0000-0002-3340-439X, Yaniv, Karina ORCID: https://orcid.org/0000-0001-5638-7150, Linkermann, Andreas, Hu, Jiong and Bibli, Sofia-Iris ORCID: https://orcid.org/0000-0001-7153-6628
bioRxiv : 2025.11.18.689033. 24 November 2025

Erlotinib induces 3D genome rearrangements in lung cancer cells activating tumor suppressor genes through FOXA2-bound Epromoters.
Swaminathan, Guruprasadh ORCID: https://orcid.org/0009-0005-4727-2032, Cordero, Julio, Günther, Stefan, Graumann, Johannes ORCID: https://orcid.org/0000-0002-3015-5850, Braun, Thomas ORCID: https://orcid.org/0000-0002-6165-4804, Dobreva, Gergana ORCID: https://orcid.org/0000-0002-4814-9416 and Barreto, Guillermo ORCID: https://orcid.org/0000-0002-7777-4712
bioRxiv : 2025.05.13.653883. 14 May 2025