Browse by Research Team

Article

Comprehensive analysis of B cell repopulation in ocrelizumab-treated patients with multiple sclerosis by mass cytometry and proteomics.
Wang, M., Otto, C., Fernández Zapata, C., Dehlinger, A., Gallaccio, G., Diekmann, L.M., Niederschweiberer, M., Schindler, P., Körtvélyessy, P., Kunkel, D., Paul, F., Ruprecht, K. and Böttcher, C.
iScience 28 (5): 112383. 16 May 2025

Immunomodulatory potential of a bibenzyl-dihydrophenanthrene derivative isolated from Calanthe cardioglossa.
Pengdee, C., Dehlinger, A., Chaichompoo, W., Kongkatitham, V., Chaotham, C., Rojsitthisak, P., Böttcher, C. and Sritularak, B.
Journal of Natural Products 88 (2): 537-545. 28 February 2025

New phenanthrenequinones from Cymbidium ensifolium roots and their anti-inflammatory activity on lipopolysaccharide-activated BV2 microglial cells.
Thant, M.T., Hasriadi, H., Poldorn, P., Jungsuttiwong, S., Rojsitthisak, P., Böttcher, C., Towiwat, P. and Sritularak, B.
RSC Advances 14 (39): 28390-28400. 5 September 2024

Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT).
Samadzadeh, S., Adnan, R., Berglova, P., Barzegar, M., Debrabant, B., Roikjaer, S.G., Levy, M., Petzold, A., Palace, J., Flanagan, E.P., Mariotto, S., Skou, S.T., Froelich, A., Lotan, I., Messina, S., Geraldes, R., Asseyer, S., Stiebel-Kalish, H., Oertel, F.C., Shaygannejad, V., Sahraian, M.A., Kim, H.J., Bennett, J.L., Böttcher, C., Zimmermann, H.G., Weinshenker, B.G., Paul, F. and Asgari, N.
Frontiers in Immunology 15 : 1380025. 2 July 2024

Protocol to characterize immune cell subpopulations in cerebrospinal fluid of patients with neuroinflammatory diseases using mass cytometry.
Gallaccio, G., Wang, M., Schlickeiser, S., Kunkel, D., Böttcher, C. and Fernández-Zapata, C.
STAR Protocols 5 (2): 103038. 27 April 2024

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19.
Radke, J., Meinhardt, J., Aschman, T., Chua, R.L., Farztdinov, V., Lukassen, S., Ten, F.W., Friebel, E., Ishaque, N., Franz, J., Huhle, V.H., Mothes, R., Peters, K., Thomas, C., Schneeberger, S., Schumann, E., Kawelke, L., Jünger, J., Horst, V., Streit, S., von Manitius, R., Körtvélyessy, P., Vielhaber, S., Reinhold, D., Hauser, A.E., Osterloh, A., Enghard, P., Ihlow, J., Elezkurtaj, S., Horst, D., Kurth, F., Müller, M.A., Gassen, N.C., Melchert, J., Jechow, K., Timmermann, B., Fernandez-Zapata, C., Böttcher, C., Stenzel, W., Krüger, E., Landthaler, M., Wyler, E., Corman, V., Stadelmann, C., Ralser, M., Eils, R., Heppner, F.L., Mülleder, M., Conrad, C. and Radbruch, H.
Nature Neuroscience 27 (3): 409-420. March 2024

New phenolic glycosides from Coelogyne fuscescens Lindl. var. brunnea and their cytotoxicity against human breast cancer cells.
Thant, M.T., Bhummaphan, N., Wuttiin, J., Puttipanyalears, C., Chaichompoo, W., Rojsitthisak, P., Punpreuk, Y., Böttcher, C., Likhitwitayawuid, K. and Sritularak, B.
ACS Omega 9 (7): 7679-7691. 20 February 2024

Diverse modulatory effects of bibenzyls from Dendrobium species on human immune cell responses under inflammatory conditions.
Kongkatitham, V., Dehlinger, A., Chaotham, C., Likhitwitayawuid, K., Böttcher, C. and Sritularak, B.
PLoS ONE 19 (2): e0292366. 1 February 2024

Multiomic spatial landscape of innate immune cells at human central nervous system borders.
Sankowski, R., Süß, P., Benkendorff, A., Böttcher, C., Fernandez-Zapata, C., Chhatbar, C., Cahueau, J., Monaco, G., Gasull, A.D., Khavaran, A., Grauvogel, J., Scheiwe, C., Shah, M.J., Heiland, D.H., Schnell, O., Markfeld-Erol, F., Kunze, M., Zeiser, R., Priller, J. and Prinz, M.
Nature Medicine 30 (1): 186-198. January 2024

Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases.
Wang, M., Dehlinger, A., Fernández Zapata, C., Golan, M., Gallaccio, G., Sander, L.E., Schlickeiser, S., Kunkel, D., Schmitz-Hübsch, T., Sawitzki, B., Karni, A., Braun, J., Loyal, L., Thiel, A., Bellmann-Strobl, J., Paul, F., Meyer-Arndt, L. and Boettcher, C.
Nature Communications 14 (1): 7728. 25 November 2023

Immunomodulatory effects of new phenanthrene derivatives from Dendrobium crumenatum.
Kongkatitham, V., Dehlinger, A., Wang, M., Poldorn, P., Weidinger, C., Letizia, M., Chaotham, C., Otto, C., Ruprecht, K., Paul, F., Rungrotmongkol, T., Likhitwitayawuid, K., Böttcher, C. and Sritularak, B.
Journal of Natural Products 86 (5): 1294-1306. 26 May 2023

Inhibitory effect of isopanduratin A on adipogenesis: a study of possible mechanisms.
Rungsa, P., San, H.T., Sritularak, B., Böttcher, C., Prompetchara, E., Chaotham, C. and Likhitwitayawuid, K.
Foods 12 (5): 1014. 27 February 2023

1,2-(13)C(2)-glucose tracing approach to assess metabolic alterations of human monocytes under neuroinflammatory conditions.
Giacomello, G., Otto, C., Priller, J., Ruprecht, K., Böttcher, C. and Parr, M.K.
Current Issues in Molecular Biology 45 (1): 765-781. 16 January 2023

Isotopic tracing of glucose metabolites in human monocytes to assess changes in inflammatory conditions.
Giacomello, G., Böttcher, C. and Parr, M.K.
STAR Protocols 3 (4): 101715. 16 December 2022

Berlin Registry of Neuroimmunological entities (BERLimmun): protocol of a prospective observational study.
Sperber, P.S., Brandt, A.U., Zimmermann, H.G., Bahr, L.S., Chien, C., Rekers, S., Mähler, A., Böttcher, C., Asseyer, S., Duchow, A.S., Bellmann-Strobl, J., Ruprecht, K., Paul, F. and Schmitz-Hübsch, T.
BMC Neurology 22 (1): 479. 14 December 2022

Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease.
Fernández Zapata, C., Giacomello, G., Spruth, E.J., Middeldorp, J., Gallaccio, G., Dehlinger, A., Dames, C., Leman, J.K.H., van Dijk, R.E., Meisel, A., Schlickeiser, S., Kunkel, D., Hol, E.M., Paul, F., Parr, M.K., Priller, J. and Böttcher, C.
Nature Communications 13 (1): 7210. 23 November 2022

Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.
Letizia, M., Wang, Y.H., Kaufmann, U., Gerbeth, L., Sand, A., Brunkhorst, M., Weidner, P., Ziegler, J.F., Böttcher, C., Schlickeiser, S., Fernández, C., Yamashita, M., Stauderman, K., Sun, K., Kunkel, D., Prakriya, M., Sanders, A.D., Siegmund, B., Feske, S. and Weidinger, C.
EMBO Molecular Medicine 14 (9): e15687. 7 September 2022

SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod.
Meyer-Arndt, L., Braun, J., Fauchere, F., Vanshylla, K., Loyal, L., Henze, L., Kruse, B., Dingeldey, M., Jürchott, K., Mangold, M., Maraj, A., Braginets, A., Böttcher, C., Nitsche, A., de la Rosa, K., Ratswohl, C., Sawitzki, B., Holenya, P., Reimer, U., Sander, L.E., Klein, F., Paul, F., Bellmann-Strobl, J., Thiel, A. and Giesecke-Thiel, C.
Journal of Neurology Neurosurgery and Psychiatry 93 (9): 960-971. September 2022

Preprint

Comprehensive cerebrospinal fluid analysis indicates key roles for B cells in multiple sclerosis.
Fernández-Zapata, C., Otto, C., Gallaccio, G., Chen, Q., Wang, M., Uluvar, B., Teves, M., Samol, C., Buthut, M., Bösl, F.R., Dehlinger, A., Jang, G.H., Böttcher, C., Radbruch, H., Priller, J., Schindler, P., Raposo, C., Shippling, S., Pedotti, R., Kunkel, D., Pietzner, M., Franke, C., Oefner, P.J., Gronwald, W., Prüß, H., Lohmeier, J., Paul, F., Ruprecht, K. and Böttcher, C.
medRxiv : 2025.01.02.24319302. 6 January 2025

Single-cell variations of circadian clock and immune gene expression in microglia and neurodegeneration.
Ouk, K., Yalcin, M., Rigat, L., Keren-Shaul, H., David, E., Knop, A., Böttcher, C., Kramer, A., Amit, I., Relógio, A. and Priller, J.
bioRxiv : 2024.06.16.599193. 16 June 2024