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| Item Type: | Article |
|---|---|
| Title: | Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate. A spectroscopic test-retest study in adult ADHD |
| Creators Name: | Kronenberg, G., Ende, G., Alm, B., Deuschle, M., Heuser, I. and Colla, M. |
| Abstract: | The anterior cingulate cortex (ACC) is crucially involved in executive control of attention. Here, seven medication-naive adult patients suffering from attention deficit/hyperactivity disorder (ADHD) were studied with 2D (1)H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [Brodmann areas 24b'-c' and 32'] twice, once before initiation of stimulant treatment and once after 5-6 weeks of methylphenidate. Upon retest, all patients demonstrated marked clinical improvement. Analysis of regional brain spectra revealed a significantly decreased signal of choline containing compounds as well as increased N-acetyl-aspartate (NAA) levels following treatment with methylphenidate whereas total creatine remained unchanged. Our results add to a growing body of evidence implicating the ACC in the pathophysiology of ADHD and suggest that subtle structural changes might be associated with aspects of clinical improvement under stimulant treatment. |
| Keywords: | Adult ADHD, Anterior Cingulate Gyrus, Attention, Methylphenidate, Magnetic Resonance Spectroscopic Imaging |
| Source: | European Archives of Psychiatry and Clinical Neuroscience |
| ISSN: | 0940-1334 |
| Publisher: | Springer |
| Volume: | 258 |
| Number: | 7 |
| Page Range: | 446-450 |
| Date: | October 2008 |
| Official Publication: | https://doi.org/10.1007/s00406-008-0810-2 |
| PubMed: | View item in PubMed |
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