Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy

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Item Type:	Article
Title:	Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy
Creators Name:	Gu, W., Sander, T., Becker, T. and Steinlein, O.K.
Abstract:	The LGI4 gene is located in a region linked to benign familial infantile convulsions (BFIC) and idiopathic generalized epilepsy. Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. A genotypic association was found for the c.1914GC --> AT polymorphism in 42 CAE patients compared with 110 population controls (chi2 = 6.66, df = 1, P = 0.01), providing evidence for a so far undetected susceptibility allele for CAE in the LGI4 region.
Keywords:	Exonic LGI4 Polymorphisms, Childhood Absence Epilepsy, Benign Familial Infantile Convulsion
Source:	Neurogenetics
ISSN:	1364-6745
Publisher:	Springer
Volume:	5
Number:	1
Page Range:	41-44
Date:	February 2004
Official Publication:	https://doi.org/10.1007/s10048-003-0158-8
PubMed:	View item in PubMed

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