Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11

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Item Type:	Article
Title:	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11
Creators Name:	Spoelgen, R., Adams, K.W., Koker, M., Thomas, A.V., Andersen, O.M., Hallett, P.J., Bercury, K.K., Joyner, D.F., Deng, M., Stoothoff, W.H., Strickland, D.K., Willnow, T.E. and Hyman, B.T.
Abstract:	In this study, we examined protein-protein interactions between two neuronal receptors, low density lipoprotein receptor-related protein (LRP) and sorLA/LR11, and found that these receptors interact, as indicated by three independent lines of evidence: co-immunoprecipitation experiments, surface plasmon resonance analysis, and fluorescence lifetime imaging microscopy (FLIM). Immunocytochemistry experiments revealed widespread co-localization of LRP and sorLA within perinuclear compartments of neurons, while FLIM analysis showed that LRP-sorLA interactions take place within a subset of these compartments.
Keywords:	LRP, sorLA, LR11, LDL Receptor, Animals, Mice, Rats
Source:	Neuroscience
ISSN:	0306-4522
Publisher:	Elsevier
Volume:	158
Number:	4
Page Range:	1460-1468
Date:	18 February 2009
Official Publication:	https://doi.org/10.1016/j.neuroscience.2008.10.061
PubMed:	View item in PubMed

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