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| Item Type: | Article |
|---|---|
| Title: | Epstein-Barr virus-associated B-cell lymphoma secondary to FCD-C therapy in patients with peripheral T-cell lymphoma |
| Creators Name: | Weisel, K.C., Weidmann, E., Anagnostopoulos, I., Kanz, L., Pezzutto, A. and Subklewe, M. |
| Abstract: | Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders occur at an increasing frequency in various hereditary and acquired states of immune dysfunction. In a few cases of T-cell lymphoma, especially in angioimmunoblastic T-cell lymphoma (AILT), EBV-associated B-cell lymphoproliferative disorders have been reported. Here, we present two cases of EBV-associated B-cell lymphoma after treatment of T-cell lymphoma (AILT and peripheral T-cell lymphoma, unspecified, PTCL-NOS) with a regimen containing alemtuzumab and fludarabine. Conventional and immunohistological tissue staining showed the typical features of highly proliferating diffuse large B-cell lymphoma in both cases. The monoclonal B-cell population displayed EBV latency type III. At the time of diagnosis the cellular immune status of both patients was severely compromised with an absolute CD4 T-cell count below <120 mul(-1). Our observation supports the notion that combination of cytotoxic drugs and immunosuppressive antibodies in patients with T-cell lymphoma may severely aggravate the already present immunodeficiency. We suggest to monitor the cellular immune status in combination with the EBV load in high risk patients for early detection-and possibly intervention-of EBV-associated lymphoma. |
| Keywords: | Epstein–Barr Virus, Secondary B-Cell Lymphoma, Peripheral T-Cell Lymphoma, AILT, Alemtuzumab, Fludarabine |
| Source: | International Journal of Hematology |
| ISSN: | 0925-5710 |
| Publisher: | Springer |
| Volume: | 88 |
| Number: | 4 |
| Page Range: | 434-440 |
| Date: | November 2008 |
| Official Publication: | https://doi.org/10.1007/s12185-008-0176-2 |
| PubMed: | View item in PubMed |
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