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| Item Type: | Article |
|---|---|
| Title: | Gender-specific differences in left ventricular remodelling and fibrosis in hypertrophic cardiomyopathy: Insights from cardiovascular magnetic resonance |
| Creators Name: | Schulz-Menger, J., Abdel-Aty, H., Rudolf, A., Elgeti, T., Messroghli, D., Utz, W., Boye, P., Bohl, S., Busjahn, A., Hamm, B. and Dietz, R. |
| Abstract: | BACKGROUND: Gender is an independent risk factor for heart failure mortality in hypertrophic cardiomyopathy (HCM). AIMS: To explore the interaction between gender, myocardial fibrosis and remodelling in HCM. METHODS: We studied 64 HCM patients (28 females, aged 51+/-16 years) categorized as non-obstructive (HNCM, n=31) or obstructive (HOCM, n=33) and 60 healthy subjects (31 females, aged 43+/-14 years). Cine imaging was performed to assess left ventricular volumes and mass. LV remodelling index (LVRI) was calculated. Extension of late gadolinium enhancement (LGE) was quantified. RESULTS: Females in the control group and in the HNCM group had a lower LVRI than males (control: 0.7+/-0.1 vs. 0.9+/-0.2 g/ml, p<0.002; HNCM: 1.1+/-0.2 vs. 1.5+/-0.5 g/ml, p<0.001). In contrast, HOCM females had a similar LVRI compared to males (1.8+/-0.5 vs. 1.7+/-0.4 g/ml, p=ns). Thus the increase in LVRI was more pronounced in females compared to males. LGE was noted in 70% of the patients. No relation was found between the presence or the quantity of myocardial fibrosis and gender in any of the patient subgroups. CONCLUSION: Our data suggest a disproportionate degree of remodelling in different forms of HCM depending on gender. Gender does not appear to influence the quantity of fibrosis as defined by LGE. |
| Keywords: | Hypertrophic Cardiomyopathy, Gender, Cardiovascular Magnetic Resonance, Late Gadolinium Enhancement |
| Source: | European Journal of Heart Failure |
| ISSN: | 1388-9842 |
| Publisher: | Oxford University Press |
| Volume: | 10 |
| Number: | 9 |
| Page Range: | 850-854 |
| Date: | September 2008 |
| Official Publication: | https://doi.org/10.1016/j.ejheart.2008.06.021 |
| PubMed: | View item in PubMed |
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