Systematic functional assessment of human protein-protein interaction maps

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Item Type:	Article
Title:	Systematic functional assessment of human protein-protein interaction maps
Creators Name:	Chaurasia, G., Herzel, H., Wanker, E.E. and Futschik, M.E.
Abstract:	Protein-protein interaction maps can contribute substantially to the discovery of protein cooperation patterns in the cell. Recently, several large-scale human protein-protein interaction maps have been generated using experimental or computational approaches. Evaluation of these maps is likely to provide a better understanding of human biology. However, careful analysis is needed, as the comparison of interaction maps of lower eukaryotes showed a surprising divergence between different maps. Here, we present a first systematic functional assessment of eight currently available large-scale human protein-protein interaction maps. The analysis shows that these maps include a large number of common proteins, but only a small number of common interactions. We detected several types of biases that need to be considered in the future utilization of these maps.
Keywords:	Protein-protein interaction, Human interactome, Networks, Systems biology
Source:	Genome Inform
ISSN:	0919-9454
Publisher:	Universal Academy Press
Volume:	17
Page Range:	36-45
Date:	2006
PubMed:	View item in PubMed

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