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Central atrial natriuretic peptide in dehydration

Item Type:Article
Title:Central atrial natriuretic peptide in dehydration
Creators Name:Bahner, U., Geiger, H., Palkovits, M., Lenkei, Z., Luft, F.C. and Heidland, A.
Abstract:To test the effect of dehydration on brain atrial natriuretic peptide (ANP) concentrations in areas important to salt appetite, water balance and cardiovascular regulation, we subjected rats to dehydration and rehydration and measured ANP concentration in 18 brain areas, as well as all relevant peripheral parameters. Water deprivation decreased body weight, blood pressure, urine volume, and plasma ANP, while it increased urine and plasma osmolality, angiotensin II, and vasopressin. ANP greatly increased in 17 and 18 brain areas (all cut cerebral cortex) by 24 h. Rehydration for 12 h corrected all changes evoked by dehydration, including elevated ANP levels in brain. We conclude that chronic dehydration results in increased ANP in brain areas important to salt appetite and water balance. These results support a role for ANP as a neuroregulatory substance that participates in salt and water balance.
Keywords:Atrial, Natriuretic Peptide, Brain, Dehydration, Thirst, Animals, Rats, Wistar Rats
Source:Clinical Neuroscience
Page Range:130-135
Date:30 March 2007
Official Publication:http://www.elitmed.hu/folyoiratok/szemle/0702/12.htm
PubMed:View item in PubMed

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