Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis

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Item Type:	Article
Title:	Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis
Creators Name:	Lietz, A., Janz, M., Sigvardsson, M., Jundt, F., Doerken, B. and Mathas, S.
Abstract:	Similar to classical Hodgkin lymphoma (HL) tumour cells, primary effusion lymphoma (PEL) originates from mature B cells but displays a non-B cell phenotype, the mechanisms and consequences of which are not yet understood. This study showed that PEL lacked DNA binding activity of the B cell-determining transcription factors E2A, EBF and Pax5. PEL overexpressed the E2A antagonists ABF-1 and Id2, which have been described to block the B-cell differentiation program in classical HL. However, in contrast to HL cells, B lineage-inappropriate genes were not similarly upregulated in PEL, and reconstitution of B cell-specific E2A homodimer activity in PEL induced apoptosis. These data demonstrate that lineage infidelity in PEL is not as pronounced as in HL, and that the loss of the B cell-specific transcription factor E2A in PEL is implicated in apoptosis protection.
Keywords:	Lymphoma, Primary Effusion Lymphoma, E2A, Hodgkin Lymphoma
Source:	British Journal of Haematology
ISSN:	0007-1048
Publisher:	Blackwell Publishing
Volume:	137
Number:	4
Page Range:	342-348
Date:	May 2007
Official Publication:	https://doi.org/10.1111/j.1365-2141.2007.06583.x
PubMed:	View item in PubMed

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