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| Item Type: | Article |
|---|---|
| Title: | Regulation of the germinal center response by microRNA-155 |
| Creators Name: | Thai, T.H., Calado, D.P., Casola, S., Ansel, K.M., Xiao, C., Xue, Y., Murphy, A., Frendewey, D., Valenzuela, D., Kutok, J.L., Schmidt-Supprian, M., Rajewsky, N., Yancopoulos, G., Rao, A. and Rajewsky, K. |
| Abstract: | MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo. |
| Keywords: | B-Lymphocytes, Cell Differentiation, Cultured Cells, Cytokines, Germinal Center, Immunoglobulin G, Lymphocyte Activation, Lymphotoxin-alpha, Lymphotoxin-beta, MicroRNAs, Nitrophenols, Peyer's Patches, Phenylacetates, Immunoglobulin Somatic Hypermutation, Spleen, T-Lymphocytes, Th1 Cells, Th2 Cells, Tumor Necrosis Factor-alpha, Animals, Mice |
| Source: | Science |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 316 |
| Number: | 5824 |
| Page Range: | 604-608 |
| Date: | 27 April 2007 |
| Official Publication: | https://doi.org/10.1126/science.1141229 |
| PubMed: | View item in PubMed |
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