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Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy

Item Type:Review
Title:Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy
Creators Name:Pagel-Langenickel, I., Buttgereit, J., Bader, M. and Langenickel, T.H.
Abstract:Natriuretic peptides (NP) represent a family of structurally homologous but genetically distinct peptide hormones involved in regulation of fluid and electrolyte balance, blood pressure, fat metabolism, cell proliferation, and long bone growth. Recent work suggests a role for natriuretic peptide receptor B (NPR-B) signaling in regulation of cardiac growth by either a direct effect on cardiomyocytes or by modulation of other signaling pathways including the autonomic nervous system. The research links NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in cardiovascular physiology and disease and will evaluate these new findings in the context of the known function of this receptor, with a perspective on how future research might further elucidate NPR-B function.
Keywords:Cardiac Hypertrophy, Natriuretic Peptide Receptor B, C-Type Natriuretic Peptide, Cardiovascular, Animals
Source:Journal of Molecular Medicine
ISSN:0946-2716
Publisher:Springer
Volume:85
Number:8
Page Range:797-810
Date:August 2007
Official Publication:https://doi.org/10.1007/s00109-007-0183-4
PubMed:View item in PubMed

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