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| Item Type: | Article |
|---|---|
| Title: | Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease |
| Creators Name: | Wolf, S.A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M. and Kempermann, G. |
| Abstract: | BACKGROUND: In aging mice, activity maintains hippocampal plasticity and adult hippocampal neurogenesis at a level corresponding to a younger age. Here we studied whether physical exercise and environmental enrichment would also affect brain plasticity in a mouse model of Alzheimer's disease (AD). METHODS: Amyloid precursor protein (APP)-23 mice were housed under standard or enriched conditions or in cages equipped with a running wheel. We assessed beta-amyloid plaque load, adult hippocampal neurogenesis, spatial learning, and mRNA levels of trophic factors in the brain. RESULTS: Despite stable beta-amyloid plaque load, enriched-living mice showed improved water maze performance, an up-regulation of hippocampal neurotrophin (NT-3) and brain-derived neurotrophic factor (BDNF) and increased hippocampal neurogenesis. In contrast, despite increased bodily fitness, wheel-running APP23 mice showed no change in spatial learning and no change in adult hippocampal neurogenesis but a down-regulation of hippocampal and cortical growth factors. CONCLUSIONS: We conclude that structural and molecular prerequisites for activity-dependent plasticity are preserved in mutant mice with an AD-like pathology. Our study might help explain benefits of activity for the aging brain but also demonstrates differences between physical and more cognitive activity. It also suggests a possible cellular correlate for the dissociation between structural and functional pathology often found in AD. |
| Keywords: | Adult Neurogenesis, Stem Cell, Neurotrophin, Water Maze, Enriched Environment, Animals, Mice |
| Source: | Biological Psychiatry |
| ISSN: | 0006-3223 |
| Publisher: | Elsevier |
| Volume: | 60 |
| Number: | 12 |
| Page Range: | 1314-1323 |
| Date: | 15 December 2006 |
| Official Publication: | https://doi.org/10.1016/j.biopsych.2006.04.004 |
| PubMed: | View item in PubMed |
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