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| Item Type: | Article |
|---|---|
| Title: | Concordant association of lipid gene variation with a combined HDL/LDL-cholesterol phenotype in two European populations |
| Creators Name: | Bauerfeind, A., Knoblauch, H., Costanza, M.C., Luganskaja, T., Toliat, M.R., Nuernberg, P., Luft, F.C., Reich, J.G. and Morabia, A. |
| Abstract: | OBJECTIVE: SNP/phenotype associations are difficult to validate. This comparative study demonstrates significant contribution of candidate genes to the variation of a complex cholesterol phenotype, measured in two general populations by a gene-based approach. METHODS: Independent samples of normolipidemic subjects from two Caucasian populations (371 Swiss and 157 Germans) were selected for a case-control-study (high LDL/low HDL versus low LDL/high HDL) with SNP genotypes as independent factors. We examined locus-specific common SNPs that densely cover the genomic regions of 10 lipid genes. RESULTS: Genotype effects were concordant in both ethnic samples, showing that APOE, ABCA1, CETP, and to a lesser degree LDLR, LIPC, and PLTP explained a substantial part of the genetic variation, whereas LPL was associated in only one sample. APOA1, LCAT, and SRB1 exerted no measurable influence. CONCLUSION: This comparison showed that sets of common SNPs representing candidate regions reproducibly validate significant linkage disequilibrium association with a complex metabolic trait. Copyright (c) 2006 S. Karger AG, Basel. |
| Keywords: | Genotype-Phenotype Association, Complex Polygenic Trait, HDL-Cholesterol, LDL-Cholesterol, Lipids, Single Nucleotide Polymorphisms |
| Source: | Human Heredity |
| ISSN: | 0001-5652 |
| Publisher: | Karger |
| Volume: | 61 |
| Number: | 3 |
| Page Range: | 123-131 |
| Date: | August 2006 |
| Official Publication: | https://doi.org/10.1159/000093773 |
| PubMed: | View item in PubMed |
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