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| Item Type: | Article |
|---|---|
| Title: | Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma |
| Creators Name: | Mathas, S., Janz, M., Hummel, F., Hummel, M., Wollert-Wulf, B., Lusatis, S., Anagnostopoulos, I., Lietz, A., Sigvardsson, M., Jundt, F., Joehrens, K., Bommert, K., Stein, H. and Doerken, B. |
| Abstract: | B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell-specific transcription factor program was disrupted by overexpression of the helix-loop-helix proteins ABF-1 and Id2. Both factors antagonized the function of the B cell-determining transcription factor E2A. As a result, expression of genes specific to B cells was lost and expression of genes not normally associated with the B lineage was upregulated. These data demonstrate the plasticity of mature human lymphoid cells and offer an explanation for the unique classical Hodgkin lymphoma phenotype. |
| Keywords: | B-Cell-Specific Activator Protein, B-Lymphocytes, Base Sequence, Basic Helix-Loop-Helix Transcription Factors, Tumor Cell Line, Dimerization, Gene Expression, Hodgkin Disease, Inhibitor of Differentiation Protein 2, Multiprotein Complexes, Phenotype, Messenger RNA, Neoplasm RNA |
| Source: | Nature Immunology |
| ISSN: | 1529-2908 |
| Publisher: | Nature Publishing Group |
| Volume: | 7 |
| Number: | 2 |
| Page Range: | 207-215 |
| Date: | February 2006 |
| Official Publication: | https://doi.org/10.1038/ni1285 |
| PubMed: | View item in PubMed |
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