Balancing cell adhesion and Wnt signaling, the key role of beta-catenin

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Item Type:	Review
Title:	Balancing cell adhesion and Wnt signaling, the key role of beta-catenin
Creators Name:	Brembeck, F.H., Rosario, M. and Birchmeier, W.
Abstract:	Controlled regulation of cell proliferation and differentiation is essential for embryonic development and requires the coordinated regulation of cell-cell adhesion and gene transcription. The armadillo repeat protein beta-catenin is an important integrator of both processes. Beta-catenin acts in the Wnt signaling pathway, activating the transcription of crucial target genes responsible for cellular proliferation and differentiation. Beta-catenin also controls E-cadherin-mediated cell adhesion at the plasma membrane and mediates the interplay of adherens junction molecules with the actin cytoskeleton. Both functions of beta-catenin are de-regulated in human malignancies, thereby leading both to the loss of cell-cell adhesion and to the increased transcription of Wnt target genes.
Keywords:	Amino Acid Sequence, Cell Adhesion, Biological Models, Molecular Sequence Data, Neoplasm Proteins, Neoplasms, Phosphorylation, Proto-Oncogenes, Amino Acid Sequence Homology, Signal Transduction, Genetic Transcription, Tyrosine, Wnt Proteins, beta Catenin, Animals
Source:	Current Opinion in Genetics & Development
ISSN:	0959-437X
Publisher:	Elsevier
Volume:	16
Number:	1
Page Range:	51-59
Date:	February 2006
Additional Information:	The original publication is available at www.sciencedirect.com
Official Publication:	https://doi.org/10.1016/j.gde.2005.12.007
PubMed:	View item in PubMed

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