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| Item Type: | Article |
|---|---|
| Title: | Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus |
| Creators Name: | Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D. and Kempermann, G. |
| Abstract: | Physical activity induces adult hippocampal neurogenesis. We here show that the acute up-regulating effect of voluntary wheel running on precursor cell proliferation decreases with continued exercise, but that continued exercise reduces the age-dependent decline in adult neurogenesis. Cell proliferation peaked at 3 days of running. After 32 days of exercise this response returned to baseline. Running-induced proliferation of transiently amplifying progenitor cells led to a consecutive increase in the number of more mature cells. Increasing age reduced adult neurogenesis at 9 months to 50% of the value at 6 weeks and to 17% at the age of 2 years. At both 1 and 2 years, precursor cell divisions remained inducible by physical activity. Exercise from 3 to 9 months of age significantly reduced the age-dependent decline in cell proliferation but (presumably in the absence of additional stimuli) did not maintain net neurogenesis at levels corresponding to a younger age. We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells. |
| Keywords: | Adult neurogenesis, Stem cell, Progenitor cell, Wheel running, Hippocampus, Animals, Mice |
| Source: | Neurobiology of Aging |
| ISSN: | 0197-4580 |
| Publisher: | Elsevier |
| Volume: | 27 |
| Number: | 10 |
| Page Range: | 1505-1513 |
| Date: | October 2006 |
| Official Publication: | https://doi.org/10.1016/j.neurobiolaging.2005.09.016 |
| PubMed: | View item in PubMed |
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