Helmholtz Gemeinschaft


Molecular analysis of axonal target specificity and synapse formation

Item Type:Review
Title:Molecular analysis of axonal target specificity and synapse formation
Creators Name:Juettner, R. and Rathjen, F.G.
Abstract:The development of neuronal connectivity requires the growth of axons to their target region and the formation of dendritic trees that extend into specific layers. Within the target region growth cones, the tips of extending axons are guided to finer target fields including specific subcellular compartments where they form synapses. In this article we highlight recent progress on molecular aspects of axonal subcellular target selection such as the axon initial segment or specific sublaminae of the vertebrate retina. We then discuss the very recent progress on the molecular analysis of synapse formation in the central nervous system, including the direction of differentiation into an inhibitory or excitatory synapse. Apparently, initial synaptic contacts are structurally and functionally modulated by neuronal activity, raising the question how neuronal activity can modify synaptic circuits. We therefore also focus on neural proteins that are up-regulated, secreted or converted by synaptic activity and, thus, might represent molecular candidates for experience-driven refinement or remodeling of synaptic connections.
Keywords:Neurofascin, neuroligin/neurexin, SynCAM, thrombospondin, CPG15, FGF22, CALEB, tPA
Source:Cellular and Molecular Life Sciences
Page Range:2811-2827
Date:21 October 2005
Official Publication:https://doi.org/10.1007/s00018-005-5299-5
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library