Prognostic value of multimarker analysis in stage III colorectal cancer: one step forward towards an individualized therapy decision

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Item Type:	Article
Title:	Prognostic value of multimarker analysis in stage III colorectal cancer: one step forward towards an individualized therapy decision
Creators Name:	Grabowski, P., Maaser, K., Hanski, C., Stein, H., Sturm, I., Hopfenmueller, W., Doerken, B., Buhr, H.J., Zeitz, M. and Scheruebl, H.
Abstract:	Background: Recently, we have analyzed new prognostic markers in colorectal cancer including neuroendocrine dif- ferentiation, overexpression of the sialyl-Lexantigen, over- expression of the peripheral benzodiazepine receptor (PBR), BAX protein expression and p53 mutational status. The pre- dictive power of all markers in combination has not yet been evaluated. Patients and Methods: Between 1989 and 1991, 48 consecutive patients underwent surgery for stage III col- orectal cancer at our hospital. All patients received a com- plete 5-year follow-up. Paraffin-embedded tumor samples were analyzed for all 5 markers. Multivariate discriminant analysis was performed to determine the prognostic value of all markers in combination. Results: Based on these prog- nostic markers a mathematical discriminant function was obtained. This function allowed to correctly predict the further course of disease in 77% of the patients specificity: 83.3%, sensitivity: 70.8%). The discriminant function was confirmed in another group of 19 patients. Single marker analysis allowed the prediction of the further course of disease only in 58–70%. Conclusion: Our study shows that in colorectal cancer, multimarker analysis is superior to unimarker analysis in predicting prognosis. The derived discriminant function allows patient tratification according to risk. Therefore, a multimarker analysis provides a rationale for future individualized risk-adapted therapies in stage III colorectal cancer.
Keywords:	Neuroendocrine Differentiation, Apoptosis, Multimarker Analysis, Colorectal Cancer
Source:	Onkologie
ISSN:	0378-584X
Publisher:	Karger
Volume:	28
Number:	8-9
Page Range:	399-403
Date:	1 August 2005
Official Publication:	https://doi.org/10.1159/000086514
PubMed:	View item in PubMed

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