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| Item Type: | Article |
|---|---|
| Title: | Prognostic value of multimarker analysis in stage III colorectal cancer: one step forward towards an individualized therapy decision |
| Creators Name: | Grabowski, P., Maaser, K., Hanski, C., Stein, H., Sturm, I., Hopfenmueller, W., Doerken, B., Buhr, H.J., Zeitz, M. and Scheruebl, H. |
| Abstract: | Background: Recently, we have analyzed new prognostic markers in colorectal cancer including neuroendocrine dif- ferentiation, overexpression of the sialyl-Lexantigen, over- expression of the peripheral benzodiazepine receptor (PBR), BAX protein expression and p53 mutational status. The pre- dictive power of all markers in combination has not yet been evaluated. Patients and Methods: Between 1989 and 1991, 48 consecutive patients underwent surgery for stage III col- orectal cancer at our hospital. All patients received a com- plete 5-year follow-up. Paraffin-embedded tumor samples were analyzed for all 5 markers. Multivariate discriminant analysis was performed to determine the prognostic value of all markers in combination. Results: Based on these prog- nostic markers a mathematical discriminant function was obtained. This function allowed to correctly predict the further course of disease in 77% of the patients specificity: 83.3%, sensitivity: 70.8%). The discriminant function was confirmed in another group of 19 patients. Single marker analysis allowed the prediction of the further course of disease only in 58–70%. Conclusion: Our study shows that in colorectal cancer, multimarker analysis is superior to unimarker analysis in predicting prognosis. The derived discriminant function allows patient tratification according to risk. Therefore, a multimarker analysis provides a rationale for future individualized risk-adapted therapies in stage III colorectal cancer. |
| Keywords: | Neuroendocrine Differentiation, Apoptosis, Multimarker Analysis, Colorectal Cancer |
| Source: | Onkologie |
| ISSN: | 0378-584X |
| Publisher: | Karger |
| Volume: | 28 |
| Number: | 8-9 |
| Page Range: | 399-403 |
| Date: | 1 August 2005 |
| Official Publication: | https://doi.org/10.1159/000086514 |
| PubMed: | View item in PubMed |
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