Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas

Tools

Item Type:	Article
Title:	Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large cell, and other peripheral T-cell lymphomas
Creators Name:	Mathas, S., Joehrens, K., Joos, S., Lietz, A., Hummel, F., Janz, M., Jundt, F., Anagnostopoulos, I., Bommert, K., Lichter, P., Stein, H., Scheidereit, C. and Doerken, B.
Abstract:	Transcription factor nuclear factor kappa B (NF-κB) plays a central role in the pathogenesis of classical Hodgkin lymphoma (cHL). In anaplastic large-cell lymphomas (ALCLs), which share molecular lesions with cHL, the NF-κB system has not been equivalently investigated. Here we describe constitutive NF-κB p50 homodimer [(p50) 2] activity in ALCL cells in the absence of constitutive activation of the IκB kinase (IKK) complex. Furthermore, (p50) 2 contributes to the NF-κB activity in Hodgkin/Reed-Sternberg (HRS) cells. Bcl-3, which is an inducer of nuclear (p50) 2 and is associated with (p50) 2 in ALCL and HRS cell lines, is abundantly expressed in ALCL and HRS cells. Notably, a selective overexpression of Bcl-3 target genes is found in ALCL cells. By immunohistochemical screening of 288 lymphoma cases, a strong Bcl-3 expression in cHL and in peripheral T-cell non-Hodgkin lymphoma (T-NHL) including ALCL was found. In 3 of 6 HRS cell lines and 25% of primary ALCL, a copy number increase of the BCL3 gene locus was identified. Together, these data suggest that elevated Bcl-3 expression has an important function in cHL and peripheral T-NHL, in particular ALCL
Keywords:	Cell Line, Dimerization, Hodgkin Disease, I-kappa B Proteins, Interleukin-9, Microarray Analysis, NF-kappa B p50 Subunit, Neoplastic Gene Expression Regulation, Oncogene Proteins v-rel, Peripheral T-Cell Lymphoma, Protein Binding, Proto-Oncogene Proteins, Transcription Factors
Source:	Blood
ISSN:	0006-4971
Publisher:	American Society of Hematology
Volume:	106
Number:	13
Page Range:	4287-4293
Date:	25 August 2005
Official Publication:	https://doi.org/10.1182/blood-2004-09-3620
PubMed:	View item in PubMed

Repository Staff Only: item control page