Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung

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Item Type:	Article
Title:	Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
Creators Name:	Shu, W., Guttentag, S., Wang, Z., Andl, T., Ballard, P., Lu, M.M., Piccolo, S., Birchmeier, W., Whitsett, J.A., Millar, S.E. and Morrisey, E.E.
Abstract:	Branching morphogenesis in the lung serves as a model for the complex patterning that is reiterated in multiple organs throughout development. {beta}-catenin and Wnt signaling mediate critical functions in cell fate specification and differentiation, but specific functions during branching morphogenesis have remained unclear. Here, we show that Wnt/{beta}-catenin signaling regulates proximal-distal differentiation of airway epithelium. Inhibition of Wnt/{beta}-catenin signaling, either by expression of Dkk1 or by tissue-specific deletion of β-catenin, results in disruption of distal airway development and expansion of proximal airways. Wnt/{beta}-catenin functions upstream of BMP4, FGF signaling, and N-myc. Moreover, we show that {beta}-catenin and LEF/TCF activate the promoters of BMP4 and N-myc. Thus, Wnt/{beta}-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling.
Keywords:	{Beta}-Catenin, BMP, Dickkopf-1, FGF, Lung Development, Wnt
Source:	Developmental Biology
ISSN:	0012-1606
Publisher:	Academic Press
Volume:	283
Number:	1
Page Range:	226-239
Date:	1 January 2005
Official Publication:	https://doi.org/10.1016/j.ydbio.2005.04.014
PubMed:	View item in PubMed

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