Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection

[thumbnail of 7830oa.pdf] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
2MB

Item Type:Article
Title:Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection
Creators Name:Kursar, M., Höpken, U.E., Koch, M., Koehler, A., Lipp, M., Kaufmann, S.H. and Mittrücker, H.W.
Abstract:Effective priming of T cell responses depends on cognate interactions between naive T cells and professional antigen-presenting cells (APCs). This contact is the result of highly coordinated migration processes, in which the chemokine receptor CCR7 and its ligands, CCL19 and CCL21, play a central role. We used the murine Listeria monocytogenes infection model to characterize the role of the CCR7/CCR7 ligand system in the generation of T cell responses during bacterial infection. We demonstrate that efficient priming of naive major histocompatibility complex (MHC) class Ia-restricted CD8+ T cells requires CCR7. In contrast, MHC class Ib-restricted CD8+ T cells and MHC class II-restricted CD4+ T cells seem to be less dependent on CCR7; memory T cell responses are independent of CCR7. Infection experiments with bone marrow chimeras or mice reconstituted with purified T cell populations indicate that CCR7 has to be expressed on CD8+ T cells and professional APCs to promote efficient MHC class Ia-restricted T cell priming. Thus, different T cell subtypes and maturation stages have discrete requirements for CCR7.
Keywords:Antigen-Presenting Cells, Bone Marrow Cells, CD8-Positive T-Lymphocytes, Chemokine CCL19, Chemokine CCL21, DNA Primers, Flow Cytometry, Immunologic Memory, Listeria Infections, Listeria monocytogenes, Lymphocyte Activation, Major Histocompatibility Complex, CCR7 Receptors, Chemokine Receptors, T-Lymphocyte Subsets, Animals, Mice
Source:Journal of Experimental Medicine
ISSN:0022-1007
Publisher:Rockefeller University Press
Volume:201
Number:9
Page Range:1447-1457
Date:2 May 2005
Additional Information:Copyright (c) 2005 by The Rockefeller University Press
Official Publication:https://doi.org/10.1084/jem.20041204
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library