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| Item Type: | Article |
|---|---|
| Title: | Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection |
| Creators Name: | Kursar, M., Höpken, U.E., Koch, M., Koehler, A., Lipp, M., Kaufmann, S.H. and Mittrücker, H.W. |
| Abstract: | Effective priming of T cell responses depends on cognate interactions between naive T cells and professional antigen-presenting cells (APCs). This contact is the result of highly coordinated migration processes, in which the chemokine receptor CCR7 and its ligands, CCL19 and CCL21, play a central role. We used the murine Listeria monocytogenes infection model to characterize the role of the CCR7/CCR7 ligand system in the generation of T cell responses during bacterial infection. We demonstrate that efficient priming of naive major histocompatibility complex (MHC) class Ia-restricted CD8+ T cells requires CCR7. In contrast, MHC class Ib-restricted CD8+ T cells and MHC class II-restricted CD4+ T cells seem to be less dependent on CCR7; memory T cell responses are independent of CCR7. Infection experiments with bone marrow chimeras or mice reconstituted with purified T cell populations indicate that CCR7 has to be expressed on CD8+ T cells and professional APCs to promote efficient MHC class Ia-restricted T cell priming. Thus, different T cell subtypes and maturation stages have discrete requirements for CCR7. |
| Keywords: | Antigen-Presenting Cells, Bone Marrow Cells, CD8-Positive T-Lymphocytes, Chemokine CCL19, Chemokine CCL21, DNA Primers, Flow Cytometry, Immunologic Memory, Listeria Infections, Listeria monocytogenes, Lymphocyte Activation, Major Histocompatibility Complex, CCR7 Receptors, Chemokine Receptors, T-Lymphocyte Subsets, Animals, Mice |
| Source: | Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Volume: | 201 |
| Number: | 9 |
| Page Range: | 1447-1457 |
| Date: | 2 May 2005 |
| Additional Information: | Copyright (c) 2005 by The Rockefeller University Press |
| Official Publication: | https://doi.org/10.1084/jem.20041204 |
| PubMed: | View item in PubMed |
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