CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations

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Item Type:	Article
Title:	CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations
Creators Name:	Arce, S., Luger, E., Muehlinghaus, G., Cassese, G., Hauser, A., Horst, A., Lehnert, K., Odendahl, M., Hoenemann, D., Heller, K.D., Kleinschmidt, H., Berek, C., Doerner, T., Krenn, V., Hiepe, F., Bargou, R., Radbruch, A. and Manz, R.A.
Abstract:	Despite the important role immunoglobulin G (IgG)-secreting plasma cells play in memory immune responses, the differentiation and homeostasis of these cells are not completely understood. Here, we studied the differentiation of human IgG-secreting cells ex vivo and in vitro, identifying these cells by the cellular affinity matrix technology. Several subpopulations of IgG-secreting cells were identified among the cells isolated from tonsils and bone marrow, particularly differing in the expression levels of CD9, CD19, and CD38. CD38 low IgG-secreting cells were present exclusively in the tonsils. A major fraction of these cells appeared to be early plasma cell precursors, as upon activation of B cells in vitro, IgG secretion preceded up-regulation of CD38, and on tonsillar sections, IgG-containing, CD38 low cells with a plasmacytoid phenotype were found in follicles, where plasma cell differentiation starts. A unitary phenotype of migratory peripheral blood IgG-secreting cells suggests that all bone marrow plasma cell populations share a common precursor cell. These data are compatible with a multistep model for plasma cell differentiation and imply that a common CD38 low IgG-secreting precursor gives rise to a diverse plasma cell compartment.
Keywords:	Antibodies, B lymphocytes, Cellular differentiation, Memory
Source:	Journal of Leukocyte Biology
ISSN:	0741-5400
Volume:	75
Page Range:	1022-1028
Date:	1 January 2004
Official Publication:	https://doi.org/10.1189/jlb.0603279
PubMed:	View item in PubMed

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