Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens

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Item Type:	Article
Title:	Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens
Creators Name:	Tadic, A., Dahmen, N., Szegedi, A., Rujescu, D., Giegling, I., Koller, G., Anghelescu, I., Fehr, C., Klawe, C., Preuss, U., Sander, T., Toliat, M., Singer, P., Bondy, B. and Soyka, M.
Abstract:	Objective: Ethanol-inhibited glutamatergic neurotransmission has been shown to mediate pathophysiological mechanisms in the development of alcoholism, including withdrawal symptoms. NMDA-receptor 2B (NR2B) is a subunit that confers a high sensitivity to ethanol-induced inhibition. Previously we had reported a lack of association between the single nucleotide polymorphism (SNP) rs1806201 in the NR2B gene (GRIN2B) and alcoholism. Shortly thereafter, an association between the polymorphism and early-onset alcoholism has been reported. One aim of the present study was to test whether the association between the GRIN2B polymorphism rs1806201 and early-onset alcoholism can be replicated in a larger sample. Moreover, we hypothesized that another genetic variation within GRIN2B (rs1806191) may have an effect in the etiology of alcoholism or withdrawal-related traits. Methods: We extended our original study sample to a size of 377 patients and 464 healthy volunteers and performed a replication study, including the second GRIN2B SNP. Associations between allele, genotype and haplotype frequencies of the two polymorphisms and alcoholism as well as with patients' phenotypes were investigated. Results: No associations were found between any of the two polymorphisms, tested individually or as haplotypes, and alcoholism, respectively withdrawal-related traits. Conclusion: Neither the analyzed SNPs nor any of their haplotypes likely modify susceptibility to alcohol dependence or withdrawal-related phenotypes.
Keywords:	Alcohol Dependence, Alcohol Withdrawal, GRIN2B, NMDA Receptor, NR2B
Source:	European Archives of Psychiatry and Clinical Neuroscience
ISSN:	0940-1334
Publisher:	Steinkopff
Volume:	255
Number:	2
Page Range:	129-135
Date:	1 January 2005
Official Publication:	https://doi.org/10.1007/s00406-004-0545-7
PubMed:	View item in PubMed

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