Support for the involvement of TPH2 gene in affective disorders

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Item Type:	Letter
Title:	Support for the involvement of TPH2 gene in affective disorders
Creators Name:	Harvey, M., Shink, E., Tremblay, M., Gagne, B., Raymond, C., Labbe, M., Walther, D.J., Bader, M. and Barden, N.
Abstract:	Disturbance of the serotonergic system has been suggested as a factor in the pathogenesis of affective disorders. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the serotonin biosynthetic pathway, and a new TPH isoform, TPH2, has been identified in the brain and localized to the long arm of chromosome 12 in a region that has been reported to contain bipolar and major depressive disorder susceptibility genes. An SNP-based association study on a case/control sample gave support to the existence of an affective disorder-associated haplotype in the TPH2 gene.
Keywords:	Bipolar Disorder, Brain, Case-Control Studies, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Isoenzymes, Pair 12 Human Chromosomes, Single Nucleotide Polymorphism, Tryptophan Hydroxylase
Source:	Molecular Psychiatry
ISSN:	1359-4184
Publisher:	Nature Publishing Group
Volume:	9
Number:	11
Page Range:	980-981
Date:	20 July 2004
Official Publication:	https://doi.org/10.1038/sj.mp.4001557
PubMed:	View item in PubMed

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