Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions

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Item Type:	Article
Title:	Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions
Creators Name:	Brembeck, F.H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M. and Birchmeier, W.
Abstract:	{Beta}-Catenin controls both cadherin-mediated cell adhesion and activation of Wnt target genes. We demonstrate here that the {beta}-catenin-binding protein BCL9-2, a homolog of the human proto-oncogene product BCL9, induces epithelial-mesenchymal transitions of nontransformed cells and increases {beta}-catenin-dependent transcription. RNA interference of BCL9-2 in carcinoma cells induces an epithelial phenotype and translocates {beta}-catenin from the nucleus to the cell membrane. The switch between {beta}-catenin's adhesive and transcriptional functions is modulated by phosphorylation of Tyr 142 of {beta}-catenin, which favors BCL9-2 binding and precludes interaction with {alpha}-catenin. During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning.
Keywords:	{Alpha}-Catenin, BCL9, Epithelial-Mesenchymal Transition, Mesoderm Patterning, Tyrosine Phosphorylationp, Wnt8, Animals, Mice, Zebrafish
Source:	Genes & Development
ISSN:	0890-9369
Publisher:	Cold Spring Harbor Laboratory Press
Volume:	18
Number:	18
Page Range:	2225-2230
Date:	15 September 2004
Official Publication:	https://doi.org/10.1101/gad.317604
PubMed:	View item in PubMed

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