Milestones of neuronal development in the adult hippocampus

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Item Type:	Editorial
Title:	Milestones of neuronal development in the adult hippocampus
Creators Name:	Kempermann, G., Jessberger, S., Steiner, B. and Kronenberg, G.
Abstract:	Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between these two fixed points and identify several developmental milestones. From a presumably bipotent radial-glia-like stem cell (type-1 cell) with astrocytic properties, development progresses over at least two stages of amplifying lineage-determined progenitor cells (type-2 and type-3 cells) to early postmitotic and to mature neurons. The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development.
Keywords:	Biological Markers, Vitamin D-Dependent Calcium-Binding Protein, Cell Division, Hippocampus, Neurological Models, Neuroglia, Neurons, Stem Cells, Animals, Mice
Source:	Trends in Neurosciences
ISSN:	0166-2236
Publisher:	Elsevier
Volume:	27
Number:	8
Page Range:	447-452
Date:	1 August 2004
Official Publication:	https://doi.org/10.1016/j.tins.2004.05.013
PubMed:	View item in PubMed

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