Met, metastasis, motility and more

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Item Type:	Review
Title:	Met, metastasis, motility and more
Creators Name:	Birchmeier, C., Birchmeier, W., Gherardi, E. and Vande Woude, G.F.
Abstract:	Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 — homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster — for downstream signalling. Pivotal roles for Met in development and cancer have been established: Met controls cell migration and growth in embryogenesis; it also controls growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to human cancer.
Keywords:	Binding Sites, Cell Line, Cell Movement, Cell Size, Hepatocyte Growth Factor, Intracellular Signaling Peptides and Proteins, Molecular Models, Morphogenesis, Neoplasm Metastasis, Neoplasms, Phosphoproteins, Non-Receptor Type 11 Protein Tyrosine Phosphatase, Protein Tyrosine Phosphatases, Proto-Oncogene Proteins c-met, Signal Transduction, Animals, Mice, Caenorhabditis Elegans , Drosophila Melanogaster
Source:	Nature Reviews Molecular Cell Biology
ISSN:	1471-0072
Publisher:	Nature Publishing Group
Volume:	4
Number:	12
Page Range:	915-925
Date:	December 2003
Official Publication:	https://doi.org/10.1038/nrm1261
PubMed:	View item in PubMed

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